DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS14 and Slc17a8

DIOPT Version :9

Sequence 1:	NP_001286591.1	Gene:	MFS14 / 46085	FlyBaseID:	FBgn0010651	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_892004.1	Gene:	Slc17a8 / 216227	MGIID:	3039629	Length:	601	Species:	Mus musculus

Alignment Length:	452	Identity:	144/452 - (31%)
Similarity:	238/452 - (52%)	Gaps:	19/452 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 FCLAMSYAWRVNLSVALVAMTDNSTSLAQNNTNTGVAPSEPGFDFFNSERYYNFTQKEKGNLQAS 96
            ||:  |:..|.||.||:|.|.:|||...........|             .:|:..:..|.:..|
Mouse    99 FCI--SFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTA-------------QFNWDPETVGLIHGS 148

  Fly    97 FFFGYIVTQVPGGYIAQRYGAKTMLMYGLGIAALITMLSPMSLQFGWVALAVMRFVMGLAQGAVH 161
            ||:||||||:|||:|:.::.|..:....:.:.:.:.|..|.:.:..:..:..:|.:.||.:|..:
Mouse   149 FFWGYIVTQIPGGFISNKFAASRVFGAAIFLTSTLNMFIPSAARVHYGCVMGVRILQGLVEGVTY 213

  Fly   162 PATHALLAKWSPADERGMLGTLCYSGAQFGTVVMLATSGFIADSVLGWPSIFYLGGACGFIWMVF 226
            ||.|.:.:||:|..||..|.|..:.|:..|.||.:..:|.:. ..:||.|:||:.|..|.||.:|
Mouse   214 PACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLV-QYIGWASVFYIYGMFGIIWYMF 277

  Fly   227 WYLFSASTPEEHRLISPGELKYITDSRSDGKMQSAEKLAPTPWKAIFSSLPFLSLLVVHCTHIFG 291
            |.|.:...|..|..||..|..||..|..:|...::.....|||:..|:|||..:::|.:....:.
Mouse   278 WLLQAYECPAAHPTISNAERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWT 342

  Fly   292 YWLLLMQIPTYMKKIYHVDIKKGALLSSLPYMVMLLLSFFFVWLSKVLQKKEGMSLSFNRKIFNS 356
            ::|||:..|.|.::::...|.|..|||::|:|||.::......|:..|:.::.::.:..|||.|.
Mouse   343 FYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNC 407

  Fly   357 IGHWIPMLSLIALGYVPADNAPLAVTLLTLTVGISGATYLGFQVNHIDLSPNYAGTLMGITNCAA 421
            .|..:....|:.:|:  :....:|::.|.|.||.||....||.|||:|::|.||..||||:|...
Mouse   408 GGFGMEATLLLVVGF--SHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVG 470

  Fly   422 NVMSGIAPVIVGQIVVDETSVTEWRLVFLLAAAFYFLGNLLFVIFGRTEVQWWDSPRDNKED 483
            .:...:.|:|||.:...:|. .||:.|||:||..::.|.:.:.:|...|.|.|..|.:..||
Mouse   471 TLSGMVCPLIVGAMTKHKTR-EEWQNVFLIAALVHYSGVIFYGVFASGEKQDWADPENLSED 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS14	NP_001286591.1	2A0114euk	19..477	CDD:129972	141/444 (32%)
MFS14	NP_001286591.1	MFS	81..466	CDD:119392	123/384 (32%)
Slc17a8	NP_892004.1	2A0114euk	88..526	CDD:129972	141/445 (32%)
		MFS	93..515	CDD:119392	137/434 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	576..601
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820