DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS14 and slc-17.5

DIOPT Version :9

Sequence 1:	NP_001286591.1	Gene:	MFS14 / 46085	FlyBaseID:	FBgn0010651	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_505139.1	Gene:	slc-17.5 / 184790	WormBaseID:	WBGene00017681	Length:	530	Species:	Caenorhabditis elegans

Alignment Length:	533	Identity:	127/533 - (23%)
Similarity:	228/533 - (42%)	Gaps:	87/533 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 FFGVR----HVQCIL--CFFCLAMSYAWRVNLSVALVAMTDNSTSLAQNNTNT------------ 65
            |..:|    ||..:|  .|||:....| .:.||::.:.   |||::|..|||.
Worm    17 FLHIRSRRLHVVLMLMYAFFCMCQMTA-HIGLSLSCMC---NSTAVALMNTNNATLVEGTESTIL 77

  Fly    66 ---------------------------GVAPSEPGFDFFNSERYYNFTQKEKGNLQASFFFGYIV 103
                                       |....:.|..|..|..:       :|.:.::.|.|..:
Worm    78 MSILENKTSESQELGGGDDGESCTKLEGKVIKDYGGTFIWSVSW-------QGYIVSAAFLGGFI 135

  Fly   104 TQVPGGYIAQRYGAKTMLMYGLGIAALITMLSP-MSLQFGWVALAVMRFVMGLAQGAVHPATHAL 167
            ...|.|.:..|:.|:.:|...:.:..:.::|.| :|:..|.......|||||:::..:.|:.:::
Worm   136 FSYPAGVLVDRFSARHILSVAILMLTIASLLMPVLSIYIGEKGAFAGRFVMGISETMLIPSINSM 200

  Fly   168 LAKWSPADERGMLGTLCYSGAQ----FGTVVM--LATSGFIADSVLGWPSIFYLGGACGFIWMVF 226
            :.||.|.:|:.:..::..:|.|    ||.:::  |..|.|      ||.||||.....|..|:|.
Worm   201 VTKWIPINEKSLAASVFTAGNQLSGMFGNILVAELCASSF------GWSSIFYSASLFGISWLVL 259

  Fly   227 WYLFSASTPEEHRLISPGELKYITDSRSDGKMQSAEKLAPTPWKAIFSSLPFLSLLVVHCTHIFG 291
            |:|...::|...|.|...||.|:.::.......|..|  .|||:.:.:|..|.||:.   ..:.|
Worm   260 WHLTVRNSPHNTRWIHKRELDYLANNIPPKHPSSVVK--KTPWRDMLTSKVFWSLMF---NSVMG 319

  Fly   292 YW---LLLMQIPTYMKKIYHVDIKKGALLSSLPYMVMLLLSFFFVWLSKVLQKKEGMSLSFNRKI 353
            ..   |:.:.||.|.|.:..:|::.....|::|::..|:....:.:|...::.|:.:|.|...|:
Worm   320 NMMIALIFVYIPVYFKDVLMLDVQSNGFYSAIPHISNLIAKLIWGYLMDKMRHKKILSPSATVKL 384

  Fly   354 FNSIGHWIPMLSLIALGYVPADNAPLAVTLLTLTVGISGATYLGFQVNHIDLSPNYAGTLMGITN 418
            ..........:|...|.|:.......|:.||:......|.:..||..:.:.::|::.|||..:..
Worm   385 SQFASMMGISVSCFFLRYMNCATPFYALVLLSSVSAFFGLSISGFYTSLLSIAPSHIGTLTSLAT 449

  Fly   419 CAANVMSGIAPVIVGQIVVDETSVTEW---RLVFLLAAAFYFLGNLLFVIFGRTEVQWWD-SPRD 479
            ....|.....|:::.......|: .||   .|:::.|:|   .|.::|::||..:||.|| |.|.
Worm   450 VIGFVGRMFTPLMISYYKTVGTA-EEWGHVLLIYVFASA---TGGIIFLLFGSGDVQNWDYSKRH 510

  Fly   480 NKEDAEQGTPLAP 492
            |  .|.....:||
Worm   511 N--TARPNALVAP 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS14	NP_001286591.1	2A0114euk	19..477	CDD:129972	121/516 (23%)
MFS14	NP_001286591.1	MFS	81..466	CDD:119392	93/397 (23%)
slc-17.5	NP_505139.1	MFS	108..497	CDD:391944	96/410 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28615
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930