Protein Alignment MYBPH and MnM

DIOPT Version :10

• Sequence 1: XP_047277161.1
• Gene: MYBPH / 4608
• HGNCID: 7552
• Length: 518
• Species: Homo sapiens
• Sequence 2: NP_647779.2
• Gene: MnM / 38384
• FlyBaseID: FBgn0035410
• Length: 1443
• Species: Drosophila melanogaster
• Alignment Length: 555
• Identity: 120/555 - (21%)
• Similarity: 187/555 - (33%)
• Gaps: 155/555 - (27%)

Human    88 PQAPAPQAPTA-STATKPAPPSEDVPSAPLL--LTLDDVSSSSVTVSWEPPERLGRLGLQGYVLE 149
            ||...|:.... .:|.:|:||..     |:|  :.|.:.....|.:.|:.|...|...:.||.:|
  Fly    12 PQGGRPKKNVHWKSAERPSPPGR-----PILTPVALPEQQPDVVNLRWDRPLHDGGSPITGYTVE 71

Human   150 LCREGASEWVPVSARPMMVTQQTVRNLALGDKFLLRVSAVSSAGAGPPAMLDQPIHIR------- 207
            ..|.|:..||..:..|:......:..|..|.::..|..|.:..|....:.|..|:.:.
  Fly    72 HRRMGSPHWVRATPTPVDRCDVCISGLEPGWRYQFRCFAENIVGRSDASELSDPLTVTLQRNAIT 136

Human   208 ----------------ENIE--------------------------------------------- 211
                            |.||
  Fly   137 VPRFIDELVDTNAVEDERIEFRVRILGEPPPEINWFKDGYEIFSSRRTKIVNDNEASVLVIHQVA 201

Human   212 ----------------------------APKIRVPRHLRQTYIRQVGETVNLQIPFQGKPKPQAT 248
                                        .||||:||......|.:..|.:.|::...|:|.|..|
  Fly   202 LTDEGEIKCTATNRAGHVITKARLMVQAPPKIRLPRTYEDGLIVEADEVLRLKVGVAGQPPPAIT 266

Human   249 WTHNGHAL-DSQRVSMRTGDQDSILFIRSAQRSDSGRYELTVRVEDLEAKAVIDILVIEKPGPPS 312
            |.|.|..: ...|..:...:::|:|.|.:..|.|.|.|.:.......|......:.|..:|.||.
  Fly   267 WLHEGEVIAPGGRFEVSNTEKNSLLKIDNVLREDRGEYMVKAWNRLGEDSTSFLVTVTARPNPPG 331

Human   313 SIRLLDVWGCNAALQWTPPQDTGNTELLGYMVQKADKKTGQWFTVLERYHPTTCTISDLIIGNSY 377
            :.:|...:|.:|.|.||.|.|.|..::..|:|:........|.........:| |:.|||.|:.|
  Fly   332 TPKLNMSFGKSATLSWTAPLDDGGCKIGNYIVEYFRVGWNVWLKAATTRALST-TLHDLIEGSEY 395

Human   378 SFRVFSENLCGLSTSATVTKELAHI--QKADIAAKPKGF--IERDFSEAP--------------- 423
            .|||.:||..||| ..:...||..|  .|..| .|||..  |..|..:.|
  Fly   396 KFRVKAENPYGLS-EPSGESELLFIPDPKRGI-TKPKSATRIAGDEKDKPKTGAGGMQVPPRRKT 458

Human   424 -SFTQPLADHTSTPGYSTQLFCSVRASPKPKIIWMKN--------------KMEIQGNPKYRALS 473
             |..:|.||  ::.|.|.:...|.:..|||::|..:.              ||:::.:|...:..
  Fly   459 LSPPRPQAD--ASTGMSPKQSPSAKRKPKPQLIDNEQLTHEMSYGTSDHALKMDVRKSPSLNSAD 521

Human   474 EQGVCTLEIRKP-----------SPFDSGVYTCKA 497
            .....|.:...|           :|.|..|.:.||
  Fly   522 SANKPTTDSSNPKLNLTLVTTTLAPLDKSVPSPKA 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYBPH	XP_047277161.1	rad23	37..>110	CDD:273167	7/22 (32%)
		FN3	112..198	CDD:238020	20/87 (23%)
		Ig	224..304	CDD:472250	19/80 (24%)
		Ig strand B	233..237	CDD:409353	1/3 (33%)
		Ig strand C	246..250	CDD:409353	1/3 (33%)
		Ig strand E	270..274	CDD:409353	2/3 (67%)
		Ig strand F	284..289	CDD:409353	1/4 (25%)
		Ig strand G	297..300	CDD:409353	0/2 (0%)
		FN3	308..396	CDD:238020	30/87 (34%)
		I-set	423..512	CDD:400151	22/116 (19%)
		Ig strand B	440..444	CDD:409353	0/3 (0%)
		Ig strand C	453..457	CDD:409353	1/3 (33%)
		Ig strand E	478..482	CDD:409353	1/3 (33%)
		Ig strand F	492..497	CDD:409353	1/4 (25%)
		Ig strand G	505..508	CDD:409353
MnM	NP_647779.2	FN3	29..127	CDD:238020	25/102 (25%)
		I-set	138..227	CDD:400151	3/88 (3%)
		Ig strand B	155..159	CDD:409565	2/3 (67%)
		Ig strand C	168..172	CDD:409565	0/3 (0%)
		Ig strand E	194..197	CDD:409565	0/2 (0%)
		Ig strand F	207..212	CDD:409565	0/4 (0%)
		Ig strand G	220..223	CDD:409565	0/2 (0%)
		Ig	243..323	CDD:472250	19/79 (24%)
		Ig strand B	251..255	CDD:409353	1/3 (33%)
		Ig strand C	264..268	CDD:409353	1/3 (33%)
		Ig strand E	289..293	CDD:409353	2/3 (67%)
		Ig strand F	303..308	CDD:409353	1/4 (25%)
		Ig strand G	316..319	CDD:409353	0/2 (0%)
		FN3	327..411	CDD:238020	30/85 (35%)
		PHA03247	<420..718	CDD:223021	29/140 (21%)