Protein Alignment MYBPH and CG14964

DIOPT Version :9

• Sequence 1: NP_004988.2
• Gene: MYBPH / 4608
• HGNCID: 7552
• Length: 477
• Species: Homo sapiens
• Sequence 2: NP_647779.2
• Gene: CG14964 / 38384
• FlyBaseID: FBgn0035410
• Length: 1443
• Species: Drosophila melanogaster
• Alignment Length: 555
• Identity: 120/555 - (21%)
• Similarity: 187/555 - (33%)
• Gaps: 155/555 - (27%)

Human    47 PQAPAPQAPTA-STATKPAPPSEDVPSAPLL--LTLDDVSSSSVTVSWEPPERLGRLGLQGYVLE 108
            ||...|:.... .:|.:|:||..     |:|  :.|.:.....|.:.|:.|...|...:.||.:|
  Fly    12 PQGGRPKKNVHWKSAERPSPPGR-----PILTPVALPEQQPDVVNLRWDRPLHDGGSPITGYTVE 71

Human   109 LCREGASEWVPVSARPMMVTQQTVRNLALGDKFLLRVSAVSSAGAGPPAMLDQPIHIR------- 166
            ..|.|:..||..:..|:......:..|..|.::..|..|.:..|....:.|..|:.:.
  Fly    72 HRRMGSPHWVRATPTPVDRCDVCISGLEPGWRYQFRCFAENIVGRSDASELSDPLTVTLQRNAIT 136

Human   167 ----------------ENIE--------------------------------------------- 170
                            |.||
  Fly   137 VPRFIDELVDTNAVEDERIEFRVRILGEPPPEINWFKDGYEIFSSRRTKIVNDNEASVLVIHQVA 201

Human   171 ----------------------------APKIRVPRHLRQTYIRQVGETVNLQIPFQGKPKPQAT 207
                                        .||||:||......|.:..|.:.|::...|:|.|..|
  Fly   202 LTDEGEIKCTATNRAGHVITKARLMVQAPPKIRLPRTYEDGLIVEADEVLRLKVGVAGQPPPAIT 266

Human   208 WTHNGHAL-DSQRVSMRTGDQDSILFIRSAQRSDSGRYELTVRVEDLEAKAVIDILVIEKPGPPS 271
            |.|.|..: ...|..:...:::|:|.|.:..|.|.|.|.:.......|......:.|..:|.||.
  Fly   267 WLHEGEVIAPGGRFEVSNTEKNSLLKIDNVLREDRGEYMVKAWNRLGEDSTSFLVTVTARPNPPG 331

Human   272 SIRLLDVWGCNAALQWTPPQDTGNTELLGYMVQKADKKTGQWFTVLERYHPTTCTISDLIIGNSY 336
            :.:|...:|.:|.|.||.|.|.|..::..|:|:........|.........:| |:.|||.|:.|
  Fly   332 TPKLNMSFGKSATLSWTAPLDDGGCKIGNYIVEYFRVGWNVWLKAATTRALST-TLHDLIEGSEY 395

Human   337 SFRVFSENLCGLSTSATVTKELAHI--QKADIAAKPKGF--IERDFSEAP--------------- 382
            .|||.:||..||| ..:...||..|  .|..| .|||..  |..|..:.|
  Fly   396 KFRVKAENPYGLS-EPSGESELLFIPDPKRGI-TKPKSATRIAGDEKDKPKTGAGGMQVPPRRKT 458

Human   383 -SFTQPLADHTSTPGYSTQLFCSVRASPKPKIIWMKN--------------KMEIQGNPKYRALS 432
             |..:|.||  ::.|.|.:...|.:..|||::|..:.              ||:::.:|...:..
  Fly   459 LSPPRPQAD--ASTGMSPKQSPSAKRKPKPQLIDNEQLTHEMSYGTSDHALKMDVRKSPSLNSAD 521

Human   433 EQGVCTLEIRKP-----------SPFDSGVYTCKA 456
            .....|.:...|           :|.|..|.:.||
  Fly   522 SANKPTTDSSNPKLNLTLVTTTLAPLDKSVPSPKA 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYBPH	NP_004988.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..73		7/26 (27%)
		UBQ	<4..>69	CDD:333228	7/22 (32%)
		FN3	71..157	CDD:238020	20/87 (23%)
		Ig	191..263	CDD:325142	17/72 (24%)
		FN3	267..355	CDD:238020	30/87 (34%)
		I-set	382..471	CDD:254352	22/116 (19%)
CG14964	NP_647779.2	FN3	29..127	CDD:238020	25/102 (25%)
		I-set	138..227	CDD:254352	3/88 (3%)
		Ig	155..224	CDD:143165	2/68 (3%)
		IG_like	243..323	CDD:214653	19/79 (24%)
		Ig	250..323	CDD:299845	17/72 (24%)
		FN3	327..411	CDD:238020	30/85 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000709
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000