DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vlc and dlgap1a

DIOPT Version :9

Sequence 1:	NP_001163056.1	Gene:	vlc / 46078	FlyBaseID:	FBgn0259978	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001189384.1	Gene:	dlgap1a / 569898	ZFINID:	ZDB-GENE-030616-580	Length:	999	Species:	Danio rerio

Alignment Length:	687	Identity:	149/687 - (21%)
Similarity:	251/687 - (36%)	Gaps:	201/687 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DRSLDSIGS--CSLDVDA-DSSDISDTSGSLNFPTPVSVRDITREFTANLR-------------- 49
            |.|.||.||  .|..:.| .:|.:..|..||   |.::...|::|.:..|:
Zfish   398 DDSGDSDGSPKPSPKMQARRASYLKATQPSL---TEMTTLKISQEHSPKLQIRSHSYLRAVSEVS 459

  Fly    50 -ERCVPNLPPQPQHKTPAYVESRSSELEHMVLSPAIVECDQEPSSNDFDETSAENSQEAPEKKPS 113
             .|.:..|.|:....:|.| .||:......:.:.:.:|...|...|:. |:.|.::.:.|
Zfish   460 INRSLDTLDPKALLASPQY-RSRNESYMRAMSTISQIEAMCESVFNEM-ESHAVDALDLP----- 517

  Fly   114 YLNLACC--VNGYSNLTTYDSKIRQDINKSREVSPIRPS-------------TSSLQYCKRNHFL 163
               :..|  :..:|.:...|....||     :.||:.|:             :|::..|...:..
Zfish   518 ---MPGCFRMRSHSYVRAIDQGCSQD-----DDSPLLPASPPRTTTTVRTIQSSTVSSCITTYKK 574

  Fly   164 ATPTLHSMPSPATKCKP---IEPNNNSNDSSGNFSSG----------SGHSNGNGSF-------- 207
            ..|.:    .|.|..||   |...:::..:...:..|          ||.||...|.
Zfish   575 TPPPV----PPRTSTKPFISITAQSSTESAQDAYMDGPGTRGEPVLHSGLSNSTESIDSMKALTA 635

  Fly   208 -IKQRVERLYGPGALAQGFYSPKKHGQSPSNAAGRSERG-------------QVEIDSLQG--SE 256
             |:....:::||.:            |..||:.......             .:.|.:|:.  .:
Zfish   636 AIEAANAQIHGPAS------------QHVSNSTMTISTAPPSPLPLPVPVPVPIPIPALEDVRRD 688

  Fly   257 LARKFKQLSPSKDYGEFRKKMQKKCSQSTTARIDEPLH--SPGLNGDLDLPVFRHLSQEFRAQLP 319
            :.||.:.||..         :|.| .||...:::|. |  :..:..|||.|.:          .|
Zfish   689 VLRKSRCLSIG---------IQSK-FQSVGVQVEEE-HGVTTAVQADLDTPDY----------TP 732

  Fly   320 TVSPKRGAPRS-CM--------APDVLLVDNESSPDHGPTDEVDHESTKMDKL---ASEEYI-ST 371
            ..||....|.: |:        |...:.:....:..|..|.: |:|....|..   ..:.:| |.
Zfish   733 ADSPVTDFPAAGCLSRQYSRDAATSTVSIQGSGNHYHACTSD-DYEDVGFDPSILPPPDPWIDSV 796

  Fly   372 SNISVEAV-----VKDGNFFLKILKEEQSRLLVLAALAEKYADALSTNPDISEDTFGLLRSASGK 431
            ...|:|.|     .:||.:|||:|:.|..|:.......| :.:..:..||   :..|.:|.|.|.
Zfish   797 IEDSLEVVGRSVCQRDGRWFLKLLQAETERMEGWCRQME-HDEKENKMPD---EVLGKIRGAVGS 857

  Fly   432 ARLLVSQKMKQFEGLCHNNLNRSPEDKFPTTLDDLQGFWDMVYLQVEHVDSIFADIEKLKSNDWK 496
            |:||:|||.:||..||..|||.:...:  ....||.|||||:.|.:|::...|.::.:||:|:|:
Zfish   858 AQLLMSQKFQQFRELCEENLNPNAHPR--PVAQDLAGFWDMLQLSIENISLKFDELHQLKANNWR 920

  Fly   497 VKAQSVADQPDLHTIPTKTIKPSKVGVSQVKTVGKASSVRVNGSAPP-----PPNSAAALKREAQ 556
                 ..|.|:                            |.....||     ||.:...|.|:
Zfish   921 -----PLDPPE----------------------------RKERRLPPPVPKKPPKAHPPLARD-- 950

  Fly   557 RKLLLEMKRQRREA--------MTAAAKLNPINVDAD 585
             :.|...::||:||        ..|:.:.|.....||
Zfish   951 -RSLESTEKQRQEARKRLMAAKRAASVRQNSATESAD 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vlc	NP_001163056.1	GKAP	246..575	CDD:281368	89/363 (25%)
dlgap1a	NP_001189384.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..213
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..418		8/19 (42%)
		GKAP	691..999	CDD:281368	90/360 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..989		19/105 (18%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:P97836	997..999
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7559
eggNOG	1	0.900	-	-		E1_KOG3971
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000823
OrthoInspector	1	1.000	-	-		otm25339
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12353
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.000