DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vlc and IL1RAPL1

DIOPT Version :9

Sequence 1:	NP_001163056.1	Gene:	vlc / 46078	FlyBaseID:	FBgn0259978	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_055086.1	Gene:	IL1RAPL1 / 11141	HGNCID:	5996	Length:	696	Species:	Homo sapiens

Alignment Length:	160	Identity:	36/160 - (22%)
Similarity:	61/160 - (38%)	Gaps:	51/160 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DFDETSA-ENSQEAPEK-----KPSYLN----LAC-------CVNGYSNLTT--------YDSKI 134
            ||:|..| :.|:.:.|:     :|:.|.    .||       |:....:||.        |:||:
Human    84 DFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKM 148

  Fly   135 ----RQDINKSREVS---------PIR-PSTSSLQYCKRNHFLATPTLHSMPSPATKCKPIEPNN 185
                :.:::||:|:|         |.| |.....:.|:      |.|..  ||...|...:....
Human   149 KYFEKAELSKSKEISCRDIEDFLLPTREPEILWYKECR------TKTWR--PSIVFKRDTLLIRE 205

  Fly   186 NSNDSSGNFSSGSGHSNGNGSFIKQRVERL 215
            ...|..||::....:    |.|:.:|...|
Human   206 VREDDIGNYTCELKY----GGFVVRRTTEL 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vlc	NP_001163056.1	GKAP	246..575	CDD:281368
IL1RAPL1	NP_055086.1	Ig1_IL1RAPL-1_like	32..135	CDD:143304	12/50 (24%)
		Ig	148..239	CDD:386229	20/96 (21%)
		IGc2	260..341	CDD:197706
		TIR	405..559	CDD:366714
		Interaction with NCS1. /evidence=ECO:0000269\|PubMed:12783849	549..644
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	659..680
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3971
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900