DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYBPC3 and hbs

DIOPT Version :9

Sequence 1:	NP_000247.2	Gene:	MYBPC3 / 4607	HGNCID:	7551	Length:	1274	Species:	Homo sapiens
Sequence 2:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	1330	Identity:	248/1330 - (18%)
Similarity:	434/1330 - (32%)	Gaps:	399/1330 - (30%)

- Green bases have known domain annotations that are detailed below.

Human     2 PEPGKK----PVSAFSKKPRSVEVAAGSPAVFEAETERAGVKVRWQRGGSDISAS------NKYG 56
            |.|..:    ||..|...|..:::..|:..:...|......||:|.:.|..:..|      .:|.
  Fly    27 PTPAAQVAAPPVQKFHLTPHDLQILEGTDTLLRCEVSNRAGKVQWTKDGFALGFSAVIPGFPRYS 91

Human    57 LATEGTRHTLTVR--------------EVGPA-------DQGSYAVIAGSSKVKFD-------LK 93
            :..:..::...::              :||||       .....:::|..|.:..:       ::
  Fly    92 VLVDAKQNAYNLQIKNATLEDDAEYQCQVGPAAGNPAIRANAKLSIVAAPSSIVIEGYARNARVE 156

Human    94 VIE---------AEKAEPMLAPAPAPAEATGAPGEAP---APAAELGESAPSPKGSSSAALNGPT 146
            |.|         ||.|.|       .||.....||.|   ||...:.::||. :.::|:.|: ..
  Fly   157 VEERQNLTLHCIAENANP-------AAEIVWFQGEVPVSTAPIVTVNQTAPK-RFTTSSTLH-LQ 212

Human   147 PGAPDD---------------------PIGLFVMRP---------QDGE-VTVGGSITFSARVAG 180
            |.|.||                     .:.|.|:.|         ..|| :..|..:..:.|..|
  Fly   213 PRAEDDYKEFSCEARHKALPPDVPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQEVQIACRSRG 277

Human   181 ASLLKPPV-VKWFKGKWVDLSSKVGQHLQLHDSYDRASKVYLF---------------------- 222
            .:   ||. :.|:: ..|.:||......:|.::      ||.|
  Fly   278 GN---PPAQLTWYR-NGVAISSPQRTSGRLSEN------VYKFTAAAEDNGANLVCEAKNLLATT 332

Human   223 ----ELHIT----DAQPAFTGSYRCEVSTKDKFDC----SNFNLTVHEAMGTGDLDLLSAFRRTS 275
                ||::|    ......:|:.:.:|....:..|    ||....:..::....|| .|.::.||
  Fly   333 PLRAELNLTVLYAPKDVYLSGANQAKVGDSVQLSCVTAPSNPQARISWSINGRPLD-NSTYKTTS 396

Human   276 LAGGG------------------------------RRISDSH----------------EDTGILD 294
            .:.||                              :.:..||                .|..||.
  Fly   397 SSDGGWVSSSNISLTIDSQSRTFIAVCHALNTELTQNVVGSHTVNVLYPPSPPLLTGYNDGDILI 461

Human   295 FSSLLK-----------------KRDSFRTPRDSKLEAPAEEDVWEILRQAPPSEYERIAFQYGV 342
            ..|:||                 |.|.........:::....::..::..:..:...:...|...
  Fly   462 SGSILKLQCSSAGGNPPPTLQWYKNDKIINAPSKLVDSKITSELSLLVNASDNNAIYKCKVQNAA 526

Human   343 TDLRGMLKRLKGMR--RDEKKSTAFQKKLEPAYQVSKGHKIRLTVELADHD--AEVKWLKNGQEI 403
            .|:.....:..|:.  .:..|.:...|.|.|      |.:.:|..:.:..:  |::.|.|:|..:
  Fly   527 IDIPLFATKTLGVHFPPETVKISVVPKNLVP------GIRAKLICDSSSSNPPAKISWWKDGIPV 585

Human   404 Q----------MSGSKYIFESIGAKRTLTISQCSLADDAAYQCVVGGEKC------STELFVKEP 452
            :          ..||....|..     :.|:|.  .|...|.|....|..      :..|.:..|
  Fly   586 EGLNLANRPGLWGGSVSTLEMY-----VNITQD--LDGIVYTCQSHNEVLQRSVHETISLDILYP 643

Human   453 PVLITRPLEDQLVMVGQRVEFECEVSEEGAQV----KWLKDGVELTREETFKYRFKKDGQRHHLI 513
            |...| |.....|.| :...|..|:...|..:    .|.|||:.::.......|...||.|  |.
  Fly   644 PKFET-PQSTTFVGV-EGAPFHVELLASGNPMVITYTWTKDGLPISSNSLSGQRLISDGPR--LN 704

Human   514 INEAMLEDAGHYALC---TSGGQALAELIVQEKKLEVYQSIADLMVG----AKDQAVFKCEVSDE 571
            |:.....|||.| :|   .|.|.||.|:.|   .:|...:|..:..|    |.:.||..|.:...
  Fly   705 ISRLSRNDAGVY-ICEALNSQGTALLEIQV---AVEYAPTITAVSEGRSFVAGEPAVLACHIQAR 765

Human   572 NVRGV---WLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYSFVPEGFACNLSAKLHFME 633
            .:...   |.::|.:|.  :|...|.......|.|..|..:|..:::.:.:......:|:...:.
  Fly   766 PLEAAHVRWSRDGYDLA--TRTISSFENGTALLQIASVERSDIGNFTCIVDNQRGAPAAQNVLLV 828

Human   634 VKIDFVPRQEPPKIHLDCPG------RIPDTIVVVAGNKLRLDVPISGDPAPTVIWQKAITQGNK 692
            |       |..|:|. ..||      |:        |.:.:|.......|.|:.||::
  Fly   829 V-------QTAPEID-HSPGFTRYAARL--------GVRAQLICRSLASPQPSFIWRR------- 870

Human   693 APARPAPDAPEDTGDSDEWVFDKKLLCETEGRVR-----VETTKDRSIFTVEGAEKEDEGVYTVT 752
                                ..|.|..:...:.:     |:.....|...:|....:|.|.|...
  Fly   871 --------------------HGKDLKMQRRNKFKSVERQVDALNFESALLIENTSPDDYGQYECV 915

Human   753 VKNPVGEDQVNLTVKVIDVPDAPAAPKISNVGEDSCTVQWEPPAYDGG-QPILGYILERKKKKSY 816
            |:|.:|:....|.......||||...::.||.:....:.| .|.:||| |......|::..:..|
  Fly   916 VRNSLGQASTTLEFSKPSRPDAPLQLRVGNVSDTGVDLNW-TPGFDGGMQTYFRLRLKQHGEDKY 979

Human   817 RWM-------RLNFDLIQELSHEARRMIEGVVYEMRVYAVNAIGMSRPSPASQPFMPIGPPSEPT 874
            :::       .::.|.::          .|..|...|.|.|..|.|:       |||
  Fly   980 KYVDAKPGHQNISLDGLK----------PGATYYFSVMAANEAGGSK-------FMP-------- 1019

Human   875 HLAVEDVSDTTVSLKWRPPERVGAGGLDGYSVEYCPEGCSEWVAALQGLTEHTSILVKDLPTGAR 939
                    |..::|         :.|...:|.||..:.....|..: |:|....:|   |...|.
  Fly  1020 --------DIKLTL---------SKGSQPHSAEYTEKDELPNVMII-GITSAAMVL---LVLNAA 1063

Human   940 LL--FRVRAHNMAGPGAPVTTTEPVTVQEILQRPRLQLPRHLRQTIQKKVG------EPVNLLIP 996
            |:  |.:|..|.:...|..:..:..:..:.....:|.:.. |:..:|||..      |.|:::..
  Fly  1064 LVAWFVIRRQNKSQSEAEPSNDDVYSKDDSQSVYKLPITA-LQADVQKKAAASTYLVENVDIIQS 1127

Human   997 FQGKPRPQ-VTWTKEGQPLAGEEV----------SIRNSPTDTILFIRAARR-----VHSGTYQV 1045
            ....|:.| .:......||...:.          |.|||.|..|..::...:     :.:|.|
  Fly  1128 TAYPPKYQESSMCTPPYPLCNPDFTRTLPNPKRHSQRNSATGMIEGMQMRSKDDHMLISNGLY-- 1190

Human  1046 TVRIENMEDKATLVLQ--VVDKPS--PPQD 1071
               |.:....::||::  .:..||  ||.|
  Fly  1191 ---IPSPSPASSLVIKGSYISSPSPAPPAD 1217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYBPC3	NP_000247.2	I-set	12..94	CDD:254352	16/115 (14%)
		Ig	15..89	CDD:299845	15/100 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	107..153		15/69 (22%)
		IG	161..256	CDD:214652	24/139 (17%)
		ig	161..245	CDD:278476	21/124 (17%)
		I-set	365..449	CDD:254352	19/101 (19%)
		IGc2	384..442	CDD:197706	12/69 (17%)
		I-set	456..541	CDD:254352	27/91 (30%)
		IGc2	468..529	CDD:197706	18/67 (27%)
		Ig	563..629	CDD:299845	12/68 (18%)
		I-set	654..768	CDD:254352	19/118 (16%)
		Ig_C5_MyBP-C	655..768	CDD:143302	18/117 (15%)
		FN3	772..862	CDD:238020	22/97 (23%)
		FN3	870..963	CDD:238020	17/94 (18%)
		IG_like	981..1062	CDD:214653	20/104 (19%)
		Ig_Titin_like	990..1062	CDD:143225	16/89 (18%)
		FN3	1066..1154	CDD:238020	5/8 (63%)
		I-set	1181..1270	CDD:254352
		IGc2	1200..1257	CDD:197706
hbs	NP_001286439.1	Ig	44..122	CDD:299845	10/77 (13%)
		IG_like	45..137	CDD:214653	13/91 (14%)
		Ig	153..231	CDD:299845	21/86 (24%)
		IG_like	258..342	CDD:214653	17/93 (18%)
		Ig	266..327	CDD:299845	13/70 (19%)
		IG_like	357..>414	CDD:214653	11/57 (19%)
		Ig	360..427	CDD:299845	10/67 (15%)
		Ig	<468..526	CDD:299845	3/57 (5%)
		I-set	547..633	CDD:254352	19/98 (19%)
		Ig	556..631	CDD:299845	16/87 (18%)
		I-set	644..735	CDD:254352	29/98 (30%)
		IGc2	668..725	CDD:197706	17/59 (29%)
		IG_like	751..829	CDD:214653	14/79 (18%)
		IGc2	753..815	CDD:197706	12/63 (19%)
		Ig	852..928	CDD:143165	16/102 (16%)
		FN3	935..1017	CDD:238020	22/99 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000