DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYBPC3 and bt

DIOPT Version :9

Sequence 1:NP_000247.2 Gene:MYBPC3 / 4607 HGNCID:7551 Length:1274 Species:Homo sapiens
Sequence 2:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster


Alignment Length:1527 Identity:339/1527 - (22%)
Similarity:550/1527 - (36%) Gaps:424/1527 - (27%)


- Green bases have known domain annotations that are detailed below.


Human     2 PEPGKKPVSAFSKKPRSVEVAAGSPAVFEAETERAGVKVRWQRGGSDISASNKYGLATEGTRHTL 66
            |....|...|..|||.::       |..|...||. |..::.....|.:.|.|      .|...:
  Fly  1313 PTKAVKAQVADLKKPETL-------ATLEDNYERP-VLEKYDPFSIDKTKSEK------STPSII 1363

Human    67 TVREVGPADQGSYAVIAGSSKVKFDLKVIEAEKAE-PMLAPAPAPAE-------ATGAPGEAPAP 123
            |....||             :||..::..:.||.: |.:.| |||.:       ....|..||.|
  Fly  1364 TPDIRGP-------------EVKLPVQETKEEKQKVPKMQP-PAPGDPPKIEVIREKRPSLAPEP 1414

Human   124 AAELGESAPSPKGSS---SAALNGPTPGAPDDPIGLFVMRPQDGEVTVGGSITFSARVAGASLLK 185
            .:..|...| |..:.   |..:|......|.:.:...::||  |||..|     ..|.....:.:
  Fly  1415 PSRRGSLIP-PADTGRRPSLIINDEKKLRPGEVMDTRLLRP--GEVGEG-----QRRRPSIDVRR 1471

Human   186 PPVVKWFKGKWVDLSSKVGQHLQ------------LHDSYD--RASKVYL-----------FELH 225
            |.|     ....||.:|....|:            :.:||.  ..|..||           |:.:
  Fly  1472 PSV-----QDLEDLINKPSTPLRDVGDGGPPSIVDVQESYSVVEDSTAYLTVGVEGSPAPTFKFY 1531

Human   226 --------------ITDAQ------------PAFTGSYRCEVSTKDKFDCSNFNLTVHEAMGTGD 264
                          :||.|            |.....|:..||.....|.:...|.|.::.|   
  Fly  1532 KGVSEILEGGRFKFLTDGQTNTITLCMRKCKPNDESKYKIVVSNIHGEDSAEMQLYVSDSSG--- 1593

Human   265 LDLLSAFRRTSLAGGGRRISDSHEDTGILDFSSLLKKRDSFRTPRDSKLEAPAEEDVWEILRQAP 329
                                        :||.::||||      |..|.:...::..|       
  Fly  1594 ----------------------------MDFRAMLKKR------RYQKWDKDEQDPNW------- 1617

Human   330 PSEYERIAFQYGVTDLRGMLKRLKGMRRDEKKSTAFQKKLEPAY-QVSKGHKIRLTVELADHDAE 393
                         .||:...|.|..:::.|:|..:|...|...: :..|..|:......:..:.:
  Fly  1618 -------------GDLKETEKPLPALKKVERKVESFLSPLIDQFAKEGKDKKVVFEARFSKPNCK 1669

Human   394 VKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCVVGGEKCSTELFVKE--PPVLI 456
            .|||....|: .:|||:.|:.......|.|:...:.|...|...:||...:..|.|:|  |....
  Fly  1670 PKWLFRKDEV-FTGSKFKFKQENDTYQLIITTPKVEDTGKYTIEIGGVSSTAFLNVEEADPTYTF 1733

Human   457 TRPLEDQLVMVGQ-RVEFECEVSEEGAQVKWLKDGVELTREETFKYRFKKD-GQRHHLIINEAML 519
            |:||:.:|....| ....||.||...|.|.|.|:..:|..::. :|...|| .....|||.:::|
  Fly  1734 TKPLKKKLEGFTQHETTLECSVSSSMANVHWFKNNTKLESDDP-RYLISKDINGNLKLIIKDSVL 1797

Human   520 EDAGHY--ALCTSGGQALAELIVQEKKLEVYQSIADLMVGAKDQAVFKCEVSDENVRGVWLKNGK 582
            :|||.|  .|.....:....|.|.|...:..:.:.......||.....||:.|......||:||:
  Fly  1798 DDAGLYRCQLDKQPDKTECNLKVTEYPYKFVKVLKSQQCIEKDTVTLACEIDDAMGEVQWLRNGE 1862

Human   583 ELVPDSRIKVSHIGRVHKLTIDD--VTPADEADYSFVPEGFACNLSAKLHFMEVKIDFVPRQEPP 645
            |:.||.||::...||..||.|.|  ||.|.:         |.|..:|.....|:.|::..|... 
  Fly  1863 EIKPDKRIQIVKDGRKRKLVIKDCKVTDAGQ---------FKCTTNADTTESEIIINYQNRFNK- 1917

Human   646 KIHLDCPGRIPDTIVVVAGNKLRLDVPISGDPAP--------TVIWQKAITQGN----------- 691
                    ::.|| ..|...||.||:.:....||        .::..::|...|           
  Fly  1918 --------KLKDT-EAVEREKLILDIELQDQTAPCDWKFNGEPIVPSESIEIKNMGGGKHQLIFS 1973

Human   692 --------------------------KAPARPAPDAPE----------------DTGDSDEWVFD 714
                                      |..:||..|.|:                ....:.:...:
  Fly  1974 SLDMSNEGEITCESGQLSSKCKLSIRKGESRPNIDCPDKFSGPISAPVLLEVPFKVSGTKQTPVE 2038

Human   715 KKLLCETEGR------VRVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPD 773
            .||.  .:|:      |.|..|.|:..|.::...::..|.|.:.:.|..|||..::.:...|||.
  Fly  2039 AKLF--KDGKPLPVKDVEVAVTDDKVTFKIKKPSRDLSGPYQIKISNGQGEDTKDVQIICQDVPQ 2101

Human   774 APAAPKISNVGEDSCTVQWEPPAYDGGQPILGYILERKK-KKSYRWMRLNFDLIQEL--SHEARR 835
            .|....|::|.:.||.|.:.||:.|||.||..|::||:. .|.:.|     :.:.|:  |....:
  Fly  2102 PPQDVDITDVYQTSCVVSFNPPSDDGGTPITKYVIERQDLSKKHGW-----ESVAEVLPSEPCLK 2161

Human   836 MIEGVV----YEMRVYAVNAIGMSRPSPASQPFM---PIGPPSEPTHLAVEDVSDTTVSLKWRPP 893
            .|:.::    |..|:.||||||.|.|:......:   |...|.:|..:.:.|.......|||..|
  Fly  2162 KIDDLIPKKQYRFRIRAVNAIGQSDPATFKNTILAKDPWDEPGKPKAVDLTDWDKDHADLKWEAP 2226

Human   894 ERVGAGGLDGYSVEYCPEGCSEWVAALQGLTEHTSILVKDLPTGARLLFRVRAHNMAGPGAPVTT 958
            |..|...:..|.|||..:..::||:..:...:..:..|..|..|.:..|||||.|.||||.|...
  Fly  2227 ETDGGDPITAYIVEYKEKFSNDWVSGKEVDGDARTATVDGLKEGQQYEFRVRAVNRAGPGEPSDK 2291

Human   959 TEPVTVQEILQRPRLQLPRHLRQTIQKKVGEPVNLLIPFQGKPRPQVTWTK-------EGQPLAG 1016
            |:.:..:....:|.: :...|:....|| |:.:...|.:.|:|.|..||.|       :.|.:..
  Fly  2292 TKSIIAKCRFVKPFI-VGEGLKNVTVKK-GQTIRFDIKYDGEPEPAATWVKGTDNLKFDNQRICL 2354

Human  1017 EEVSIRNSPTDTILFIRAARRVHSGTYQVTVRIEN--MEDKATLVLQVVDKPSP------PQDLR 1073
            :::. |||.    :.|:.:.|..:|.|::.:...:  :|.:|.:|  |:|:|.|      |:::|
  Fly  2355 DQLE-RNSS----ITIKKSVRKDTGKYKLVLSNSSGTIESEAQVV--VLDRPLPPGGPFEPEEIR 2412

Human  1074 VTDAWGLNVALEWKPPQDVGNTELWGYTVQKADKKTMEWFTVLEHYRRTHCVVPE--------LI 1130
            .:     ::.::||.|.|.|..|:.||.:::.|::|..|....|       |.|.        |.
  Fly  2413 AS-----HIKMKWKRPDDDGGCEISGYALERMDEETGRWIPAGE-------VGPNETSFDFKGLT 2465

Human  1131 IGNGYYFRVFSQNMVGFSDRAATTKEPVFIPRPGITYEPPNYKALDFSE---------------- 1179
            ....|.|||.:.|..|.|: ...|.:.:....|.....||:...:|..:                
  Fly  2466 PNKKYKFRVKAINKEGESE-PLETFDAIVARNPYDPPSPPSQPVIDDYDNKSVLLKWKRPPSDGG 2529

Human  1180 --------------APSFTQ--------------------------------------------- 1185
                          |||:::                                             
  Fly  2530 RPITHYIVEIKDKFAPSWSEVAKTDDPNPECNVEGLKEKMVYQFRVRAVNKAGPSEPSQPTDNHL 2594

Human  1186 -------PLVNRS------VIAGYTAMLCCAVRGSPKPKISW-FKNGLDLGEDARFRM------- 1229
                   |.::||      :.:|.|......|.|.|.|::.| :::.:.|....|.::       
  Fly  2595 CKHKNLKPQIDRSTFKRVTIKSGRTHKWSVDVLGEPIPELHWSWRDDIPLTNGDRIKIENVDYHT 2659

Human  1230 -FSKQGVLTLEIRKPCPFDGGIYVCRATNLQG 1260
             ||    :|..:||    |.|.|..:|.|..|
  Fly  2660 DFS----ITNVLRK----DSGFYTLKAENRNG 2683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYBPC3NP_000247.2 I-set 12..94 CDD:254352 17/81 (21%)
Ig 15..89 CDD:299845 14/73 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 107..153 13/55 (24%)
IG 161..256 CDD:214652 27/145 (19%)
ig 161..245 CDD:278476 25/134 (19%)
I-set 365..449 CDD:254352 19/84 (23%)
IGc2 384..442 CDD:197706 14/57 (25%)
I-set 456..541 CDD:254352 27/88 (31%)
IGc2 468..529 CDD:197706 22/64 (34%)
Ig 563..629 CDD:299845 24/67 (36%)
I-set 654..768 CDD:254352 30/180 (17%)
Ig_C5_MyBP-C 655..768 CDD:143302 30/179 (17%)
FN3 772..862 CDD:238020 32/96 (33%)
FN3 870..963 CDD:238020 30/92 (33%)
IG_like 981..1062 CDD:214653 21/89 (24%)
Ig_Titin_like 990..1062 CDD:143225 18/80 (23%)
FN3 1066..1154 CDD:238020 26/101 (26%)
I-set 1181..1270 CDD:254352 25/147 (17%)
IGc2 1200..1257 CDD:197706 16/65 (25%)
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845 14/89 (16%)
IG_like 1503..1588 CDD:214653 15/84 (18%)
I-set 1639..1724 CDD:254352 19/85 (22%)
IG 1750..1821 CDD:214652 22/71 (31%)
IGc2 1750..1806 CDD:197706 20/56 (36%)
I-set 1826..1909 CDD:254352 27/91 (30%)
Ig 1831..1897 CDD:299845 24/74 (32%)
I-set 1914..1998 CDD:254352 12/93 (13%)
Ig 2020..2095 CDD:299845 14/76 (18%)
FN3 2100..2194 CDD:238020 32/98 (33%)
FN3 2203..2292 CDD:238020 29/88 (33%)
I-set 2311..2395 CDD:254352 22/91 (24%)
Ig 2321..2395 CDD:299845 18/80 (23%)
FN3 2399..2493 CDD:238020 27/106 (25%)
FN3 2501..2590 CDD:238020 6/88 (7%)
I-set 2602..2693 CDD:254352 23/90 (26%)
Ig 2619..2693 CDD:299845 19/73 (26%)
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 58 1.000 Domainoid score I10772
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13817
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.100

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