DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYBPC3 and CG14964

DIOPT Version :9

Sequence 1:	NP_000247.2	Gene:	MYBPC3 / 4607	HGNCID:	7551	Length:	1274	Species:	Homo sapiens
Sequence 2:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster

Alignment Length:	942	Identity:	206/942 - (21%)
Similarity:	318/942 - (33%)	Gaps:	266/942 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   458 RPLED-QLVMVGQRVEF-----------------ECEVSEEGAQVKWLKDGVELTREETFKYRFK 504
            |||.| ...:.|..||.                 .|:|...|.:..|             :|:|:
  Fly    56 RPLHDGGSPITGYTVEHRRMGSPHWVRATPTPVDRCDVCISGLEPGW-------------RYQFR 107

Human   505 KDGQRHHLIINEAMLEDAGHYALCTSGGQALAE---LIVQEKKLEVYQSIADLM--VGAKDQAV- 563
            ...:.   |:..             |....|::   :.:|...:.|.:.|.:|:  ...:|:.:
  Fly   108 CFAEN---IVGR-------------SDASELSDPLTVTLQRNAITVPRFIDELVDTNAVEDERIE 156

Human   564 FKCEVSDENVRGV-WLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYSFVPEGFACNLSA 627
            |:..:..|....: |.|:|.|:....|.|:.:......|.|..|...||.:........|.::..
  Fly   157 FRVRILGEPPPEINWFKDGYEIFSSRRTKIVNDNEASVLVIHQVALTDEGEIKCTATNRAGHVIT 221

Human   628 KLHFMEVKIDFVPRQEPPKIHLDCPGRIPDTIVVVAGNKLRLDVPISGDPAPTVIWQKAITQGNK 692
            |...|.        |.||||.|  |....|.::|.|...|||.|.::|.|.|.:.|   :.:|..
  Fly   222 KARLMV--------QAPPKIRL--PRTYEDGLIVEADEVLRLKVGVAGQPPPAITW---LHEGEV 273

Human   693 -APARPAPDAPEDTGDSDEWVFDKKLLCETEGRVRVETTKDRSIFTVEGAEKEDEGVYTVTVKNP 756
             ||.                           ||..|..|:..|:..::...:||.|.|.|...|.
  Fly   274 IAPG---------------------------GRFEVSNTEKNSLLKIDNVLREDRGEYMVKAWNR 311

Human   757 VGEDQVNLTVKVIDVPDAPAAPKISNVGEDSCTVQWEPPAYDGGQPILGYILERKKKKSYRWMRL 821
            :|||..:..|.|...|:.|..||::.....|.|:.|..|..|||..|..||:|..:.....|::.
  Fly   312 LGEDSTSFLVTVTARPNPPGTPKLNMSFGKSATLSWTAPLDDGGCKIGNYIVEYFRVGWNVWLKA 376

Human   822 NFDLIQELSHEARRMIEGVVYEMRVYAVNAIGMSRPSPASQ-PFMP-----IGPPSEPTHLAVED 880
              ...:.||.....:|||..|:.||.|.|..|:|.||..|: .|:|     |..|...|.:|.::
  Fly   377 --ATTRALSTTLHDLIEGSEYKFRVKAENPYGLSEPSGESELLFIPDPKRGITKPKSATRIAGDE 439

Human   881 VSDTTVSLKWRPPERVGAGGLD-------------------GYSVEYCPEGCSEWVAAL------ 920
                    |.:|  :.||||:.                   |.|.:..|....:....|
  Fly   440 --------KDKP--KTGAGGMQVPPRRKTLSPPRPQADASTGMSPKQSPSAKRKPKPQLIDNEQL 494

Human   921 -----QGLTEHTSILVKDLPTGARLLFRVRAH----NMAGPGAPVT--TTEPVTVQEIL---QRP 971
                 .|.::|.  |..|:.....|.....|:    :.:.|...:|  ||....:.:.:   :.|
  Fly   495 THEMSYGTSDHA--LKMDVRKSPSLNSADSANKPTTDSSNPKLNLTLVTTTLAPLDKSVPSPKAP 557

Human   972 RLQLPRHLRQTIQKKVGEPVNLLIPFQGKPRPQVTWTKE-------------GQPLAGEEVSIRN 1023
            |......|:....|..|.|.: ..|.|.||:|..|...|             ..|...:...:|.
  Fly   558 RTPATSPLKLFNPKPSGAPKD-RSPVQPKPQPLPTPPMETPDKASPNPKRSLSPPNKRQPPPLRK 621

Human  1024 SPTD------TILFIRAARRVHSGTYQVTVRIENM-----EDKATLVLQV--------------- 1062
            |||.      |...:|:|..|..|..|...|....     .:..||.|.|
  Fly   622 SPTPPEPIKVTPALLRSAEPVQLGVNQNVRRFSGQTLSPARNVPTLALAVASGVSAVIGEKLPTI 686

Human  1063 -VDKPSPPQDLRVTDAWGLNVALEWKP-----PQDVGNTELWGYTVQKADKKTMEWFTVLEHYRR 1121
             :..|..||:....       .||..|     |:...|...:..:..|.|
  Fly   687 EISAPPTPQEEEPP-------VLERSPSPEPAPKSQSNARRFSRSADKHD--------------- 729

Human  1122 THCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVF-------IPRPGITYEPPNYKALDFSE 1179
                  ::...|.:...||.:|    |......|:..|       |..|.|:...|:...|:|:.
  Fly   730 ------DVHTSNEFMLVVFDKN----SKVKDKDKQDSFELDLEDAIQPPPISISAPDLAFLEFTN 784

Human  1180 APSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTLEIRKPC 1244
            ..: |.|| .|||.:  |.:|.       :..::.|...::|.:.::.|..|:..::|     |.
  Fly   785 LHT-TFPL-RRSVSS--TELLY-------ERAMARFYEAVELEQASKSRKTSRDKLVT-----PV 833

Human  1245 PFD---------GGIYVCRATNLQGEARCECR 1267
            |..         |.|  ..|..|..|.|.|.|
  Fly   834 PHQTPANLRKRLGSI--SEAERLSFERRSEMR 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYBPC3	NP_000247.2	I-set	12..94	CDD:254352
		Ig	15..89	CDD:299845
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	107..153
		IG	161..256	CDD:214652
		ig	161..245	CDD:278476
		I-set	365..449	CDD:254352
		IGc2	384..442	CDD:197706
		I-set	456..541	CDD:254352	16/103 (16%)
		IGc2	468..529	CDD:197706	10/77 (13%)
		Ig	563..629	CDD:299845	14/67 (21%)
		I-set	654..768	CDD:254352	29/114 (25%)
		Ig_C5_MyBP-C	655..768	CDD:143302	29/113 (26%)
		FN3	772..862	CDD:238020	30/89 (34%)
		FN3	870..963	CDD:238020	23/128 (18%)
		IG_like	981..1062	CDD:214653	25/104 (24%)
		Ig_Titin_like	990..1062	CDD:143225	23/95 (24%)
		FN3	1066..1154	CDD:238020	15/92 (16%)
		I-set	1181..1270	CDD:254352	23/96 (24%)
		IGc2	1200..1257	CDD:197706	11/65 (17%)
CG14964	NP_647779.2	FN3	29..127	CDD:238020	16/99 (16%)
		I-set	138..227	CDD:254352	18/88 (20%)
		Ig	155..224	CDD:143165	15/68 (22%)
		IG_like	243..323	CDD:214653	28/109 (26%)
		Ig	250..323	CDD:299845	26/102 (25%)
		FN3	327..411	CDD:238020	28/85 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000709
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X825
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.000