DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and FAA2

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_010931.3	Gene:	FAA2 / 856734	SGDID:	S000000817	Length:	744	Species:	Saccharomyces cerevisiae

Alignment Length:	716	Identity:	181/716 - (25%)
Similarity:	310/716 - (43%)	Gaps:	93/716 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 EAKIVRNDDNEL----TYRTTDPPRDVHVKMLQENIDTLEKVFNYVAKTYTSKRCLGTRQILSEE 126
            :|..:.|.|||.    .||::....:: |..:.:|:.|....|.:.|:.:..:.|||:|.|....
Yeast    58 QAVAISNPDNEAGFSSIYRSSLSSENL-VSCVDKNLRTAYDHFMFSARRWPQRDCLGSRPIDKAT 121

  Fly   127 DEVQQNGRVFKKYNLGDYKWKTFTEAERTAANFGRGLRELGQKPREN--------IVIFAETRAE 183
            ...::.           :::::::...:...|.|.|:..|....|:.        :.|.:....|
Yeast   122 GTWEET-----------FRFESYSTVSKRCHNIGSGILSLVNTKRKRPLEANDFVVAILSHNNPE 175

  Fly   184 WMIAAHGCFKQAMPIVTVYATLGDDGVAHCITETEVTTVITSHDLLPKFKTLLDKCPLVKTII-- 246
            |::....|...::....:|.|||.:...:.:..||...:|.:...:.....::.....|.|::
Yeast   176 WILTDLACQAYSLTNTALYETLGPNTSEYILNLTEAPILIFAKSNMYHVLKMVPDMKFVNTLVCM 240

  Fly   247 ---------YIEDQLQKTETTGFKEGVKILPFNQVVKTGQDSKFEHVPPKGDDIAIIMYTSGSTG 302
                     .:.:.|...:.....|.:......||.:.|..:|...:||..|.:..|.:|||:||
Yeast   241 DELTHDELRMLNESLLPVKCNSLNEKITFFSLEQVEQVGCFNKIPAIPPTPDSLYTISFTSGTTG 305

  Fly   303 TPKGVLLSHKNCIATMKGFVDMVPIYPD-------DVLIGFLPLAHVFELVAESVCLMTGVPIGY 360
            .||||.:||:|..:.:........|.||       |:.  ||||||:||.:..:..|..|..||:
Yeast   306 LPKGVEMSHRNIASGIAFAFSTFRIPPDKRNQQLYDMC--FLPLAHIFERMVIAYDLAIGFGIGF 368

  Fly   361 ---STPLTLIDTSSKIKRGCKGDATVLKPTCMTSVPLILDRISKGINDKVNSGSAFKKSLFKFLY 422
               ..|..|::           |..:|||..:..||.||.|...||.:.::..:..:......|.
Yeast   369 LHKPDPTVLVE-----------DLKILKPYAVALVPRILTRFEAGIKNALDKSTVQRNVANTILD 422

  Fly   423 QYKVKWVQRG-----------YKTPLIDKLVFKKVAKLMG-GKVRIIMSGGAPLSADTHEQIKTC 475
            ....::..||           |...|||     |:...:| .....|::|.||:|.||...:::.
Yeast   423 SKSARFTARGGPDKSIMNFLVYHRVLID-----KIRDSLGLSNNSFIITGSAPISKDTLLFLRSA 482

  Fly   476 LCLELIQGYGLTETTSGATVMDYRDMTYGRTGGPLTVCDIRLVNWEEGNYRVTNKPYPQGEVLIG 540
            |.:.:.||||||||.:|..:.:..:...|..|......:.||.:..|..|.....  .:||:.|.
Yeast   483 LDIGIRQGYGLTETFAGVCLSEPFEKDVGSCGAIGISAECRLKSVPEMGYHADKD--LKGELQIR 545

  Fly   541 GECVSQGYYKLPGKTNEDFFEEDGQRWFKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLGKV 605
            |..|.:.|:|.|.:|:: ..::||  ||.|||:..|...|.:.:|||.|:..||..|||::..|:
Yeast   546 GPQVFERYFKNPNETSK-AVDQDG--WFSTGDVAFIDGKGRISVIDRVKNFFKLAHGEYIAPEKI 607

  Fly   606 ES-ELKTCGIIENICVYGDPTKQYTVALVVPNQNHLEE-LAQKHGLGDKSFEELCSSPIIE---- 664
            |: .|.:|..|..|.|:|||.|.:.|.:|..:.:..:. ||.||    ...:......::|
Yeast   608 ENIYLSSCPYITQIFVFGDPLKTFLVGIVGVDVDAAQPILAAKH----PEVKTWTKEVLVENLNR 668

  Fly   665 -KAILKEIAEHARKCK--LQKYEVPAAITLCKEVWSPDMGLVTAAFKLKRKDIQDRYQHDINRMY 726
             |.:.||......||.  ||.:|....|.:..|..:.:..:||..||:||......::..::::|
Yeast   669 NKKLRKEFLNKINKCTDGLQGFEKLHNIKVGLEPLTLEDDVVTPTFKIKRAKASKFFKDTLDQLY 733

  Fly   727 A 727
            |
Yeast   734 A 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	171/681 (25%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	162/633 (26%)
FAA2	NP_010931.3	LC-FACS_euk	126..734	CDD:341250	162/645 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53493
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820