Protein Alignment Acsl and FAA4

DIOPT Version :10

• Sequence 1: NP_001260810.1
• Gene: Acsl / 46068
• FlyBaseID: FBgn0263120
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: NP_013974.1
• Gene: FAA4 / 855288
• SGDID: S000004860
• Length: 694
• Species: Saccharomyces cerevisiae
• Alignment Length: 690
• Identity: 238/690 - (34%)
• Similarity: 354/690 - (51%)
• Gaps: 62/690 - (8%)

  Fly    82 TDPPRDVHVK---MLQENIDTLEKVFNYVAKTYTSKRCLGTRQILSEED--EVQQNGRVFKK--- 138
            |.|.|::.||   :::....:...::.:..:.:|..   |.|..::..|  ::.:..:...|
Yeast    18 TAPRRNIRVKDQPLIRPINSSASTLYEFALECFTKG---GKRDGMAWRDIIDIHETKKTIVKRVD 79

  Fly   139 ------------YNLGDYKWKTFTEAERTAANFGRGLRELGQKPR-EN-IVIFAETRAEWMIAAH 189
                        |.|..|...|:.|......:.||||.::|.||. || ..|||.|..:||....
Yeast    80 GKDKPIEKTWLYYELTPYITMTYEEMICVMHDIGRGLIKIGVKPNGENKFHIFASTSHKWMKTFL 144

  Fly   190 GCFKQAMPIVTVYATLGDDGVAHCITETEVTTVITSHDLLPKFKTLLDKCPLVKTIIYIE----- 249
            ||..|.:|:||.|.|||:.|:.|.:.||:...:.|.:.||.|....|.....||.:|:.|
Yeast   145 GCMSQGIPVVTAYDTLGESGLIHSMVETDSVAIFTDNQLLSKLAVPLKTAKNVKFVIHNEPIDPS 209

  Fly   250 DQLQ--------KTETTGFKE---GVKILPFNQVVKTGQDSKFE---HVPPKGDDIAIIMYTSGS 300
            |:.|        |......||   .:||..|:::::.|:.:|.|   |. ||.:|.|.|||||||
Yeast   210 DKRQNGKLYKAAKDAVDKIKEVRPDIKIYSFDEIIEIGKKAKDEVELHF-PKPEDPACIMYTSGS 273

  Fly   301 TGTPKGVLLSHKNCIATMKGFVDMVP--IYPDDVLIGFLPLAHVFELVAESVCLMTGVPIGYSTP 363
            |||||||:|:|.|.:|.:.|....|.  |.|.|.:|.||||||:|||..|.........:||:..
Yeast   274 TGTPKGVVLTHYNIVAGIGGVGHNVIGWIGPTDRIIAFLPLAHIFELTFEFEAFYWNGILGYANV 338

  Fly   364 LTLIDTSSKIKRGCKGDATVLKPTCMTSVPLILDRISKGINDKVNSGSAFKKSLFKFLYQYKVKW 428
            .||..||:   |.|:||....|||.|..|..:.:.:.|||..|:|....:.::||..:|..|.:.
Yeast   339 KTLTPTST---RNCQGDLMEFKPTVMVGVAAVWETVRKGILAKINELPGWSQTLFWTVYALKERN 400

  Fly   429 VQRGYKTPLIDKLVFKKVAKLMGGKVRIIMSGGAPLSADTHEQIKTCLCLELIQGYGLTETTSGA 493
            :.   .:.|:..|:||::.:..||.:|.|::||:.:|.|..:.:...||..|| ||||||..:.|
Yeast   401 IP---CSGLLSGLIFKRIREATGGNLRFILNGGSAISIDAQKFLSNLLCPMLI-GYGLTEGVANA 461

  Fly   494 TVMDYRDMTYGRTGGPLTVCDIRLVNWEEGNYRVTNKPYPQGEVLIGGECVSQGYYKLPGKTNED 558
            .|::.....||..|..:.....:||:.|:..|...|.   |||:|..|..:...|||.|.:| ..
Yeast   462 CVLEPEHFDYGIAGDLVGTITAKLVDVEDLGYFAKNN---QGELLFKGAPICSEYYKNPEET-AA 522

  Fly   559 FFEEDGQRWFKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLGKVESELKTCGIIENICVYGD 623
            .|.:||  ||:||||.|....|.:|||||||:|||...|||::|.|:||..::...::|||||.|
Yeast   523 AFTDDG--WFRTGDIAEWTPKGQVKIIDRKKNLVKTLNGEYIALEKLESIYRSNPYVQNICVYAD 585

  Fly   624 PTKQYTVALVVPNQNHLEELAQKHGL--GDKSFEELCSSPIIEKAILKEIAEHARKCKLQKYEVP 686
            ..|...|.:||||..||.:||.:.|:  ..:..|.......::.|:.|::...|:...|...|:.
Yeast   586 ENKVKPVGIVVPNLGHLSKLAIELGIMVPGEDVESYIHEKKLQDAVCKDMLSTAKSQGLNGIELL 650

  Fly   687 AAITLCKEVWSPDMGLVTAAFKLKRKDIQDRYQHDINRMY 726
            ..|...:|.|:|:.||||:|.||||:||....:.|:.|:|
Yeast   651 CGIVFFEEEWTPENGLVTSAQKLKRRDILAAVKPDVERVY 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	LC_FACS_euk1	142..714	CDD:341294	221/596 (37%)
FAA4	NP_013974.1	LC_FACS_euk1	96..678	CDD:341294	221/595 (37%)
		PRK04319	<230..>285	CDD:235279	27/55 (49%)