Protein Alignment Acsl and FAA1

DIOPT Version :10

• Sequence 1: NP_001260810.1
• Gene: Acsl / 46068
• FlyBaseID: FBgn0263120
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: NP_014962.3
• Gene: FAA1 / 854495
• SGDID: S000005844
• Length: 700
• Species: Saccharomyces cerevisiae
• Alignment Length: 683
• Identity: 241/683 - (35%)
• Similarity: 353/683 - (51%)
• Gaps: 82/683 - (12%)

  Fly   103 VFNYVAKTYTSKR---CLGTRQILSEEDEVQQNGRVFKK--------------YNLGDYKWKTFT 150
            |:.:|.:.:...:   .:|.|.:....:|.:.   |.||              |.|..|.:.:|.
Yeast    42 VYEFVLECFQKNKNSNAMGWRDVKEIHEESKS---VMKKVDGKETSVEKKWMYYELSHYHYNSFD 103

  Fly   151 EAERTAANFGRGLRELGQKPREN--IVIFAETRAEWMIAAHGCFKQAMPIVTVYATLGDDGVAHC 213
            :........||||.::|.||.::  :.::|.|..:||....|...|.:|:||.|.|||:.|:.|.
Yeast   104 QLTDIMHEIGRGLVKIGLKPNDDDKLHLYAATSHKWMKMFLGAQSQGIPVVTAYDTLGEKGLIHS 168

  Fly   214 ITETEVTTVITSHDLLPKFKTLLDKCPLVKTIIYI-----EDQLQKTE--------TTGFKE--- 262
            :.:|....:.|.:.|||.....:.....||.||:.     ||:.|..:        ....||
Yeast   169 LVQTGSKAIFTDNSLLPSLIKPVQAAQDVKYIIHFDSISSEDRRQSGKIYQSAHDAINRIKEVRP 233

  Fly   263 GVKILPFNQVVKTGQDS--KFEHVPPKGDDIAIIMYTSGSTGTPKGVLLSHKNCIATMKG----- 320
            .:|...|:.::|.|::|  :.:..||..||:..|||||||||.||||:|.|.|.:|.:.|
Yeast   234 DIKTFSFDDILKLGKESCNEIDVHPPGKDDLCCIMYTSGSTGEPKGVVLKHSNVVAGVGGASLNV 298

  Fly   321 --FVDMVPIYPDDVLIGFLPLAHVFELVAESVCLMTGVPIGYSTPLTLIDTSSKIKRGCKGDATV 383
              ||...     |.:|.||||||:||||.|.:....|..|||:|..||  |||.: |.|:||...
Yeast   299 LKFVGNT-----DRVICFLPLAHIFELVFELLSFYWGACIGYATVKTL--TSSSV-RNCQGDLQE 355

  Fly   384 LKPTCMTSVPLILDRISKGINDKVNSGSAFKKSLFKFLYQYKVKWVQRGYKTP---LIDKLVFKK 445
            .|||.|..|..:.:.:.|||.:::::.....|.:|...|..|:. :|| ...|   .:..|||||
Yeast   356 FKPTIMVGVAAVWETVRKGILNQIDNLPFLTKKIFWTAYNTKLN-MQR-LHIPGGGALGNLVFKK 418

  Fly   446 VAKLMGGKVRIIMSGGAPLSADTHEQIKTCLCLELIQGYGLTETTSGATVMDYRDMTYGRTGGPL 510
            :....||::|.:::||:|:|.|..|.|...:|..|| |||||||.:..|::|..:...| ..|.|
Yeast   419 IRTATGGQLRYLLNGGSPISRDAQEFITNLICPMLI-GYGLTETCASTTILDPANFELG-VAGDL 481

  Fly   511 TVC-DIRLVNWEEGNYRVTNKPYPQGEVLIGGECVSQGYYKLPGKTNEDFFEEDGQRWFKTGDIG 574
            |.| .::||:.||..|...|.   ||||.|.|..|:..|||...:|:: ....||  ||||||||
Yeast   482 TGCVTVKLVDVEELGYFAKNN---QGEVWITGANVTPEYYKNEEETSQ-ALTSDG--WFKTGDIG 540

  Fly   575 EIQADGVLKIIDRKKDLVKLQAGEYVSLGKVESELKTCGIIENICVYGDPTKQYTVALVVPNQNH 639
            |.:|:|.||||||||:|||...|||::|.|:||..::...:.|||||.|.:|...|.::|||...
Yeast   541 EWEANGHLKIIDRKKNLVKTMNGEYIALEKLESVYRSNEYVANICVYADQSKTKPVGIIVPNHAP 605

  Fly   640 LEELAQKHGLGDKSFEELCSSPIIE---------KAILKEIAEHARKCKLQKYEVPAAITLCKEV 695
            |.:||:|.|:    .|:..||..||         ||:..::.:..:...|...|:.|.|......
Yeast   606 LTKLAKKLGI----MEQKDSSINIENYLEDAKLIKAVYSDLLKTGKDQGLVGIELLAGIVFFDGE 666

  Fly   696 WSPDMGLVTAAFKLKRKDIQDRYQHDINRMYAS 728
            |:|..|.||:|.|||||||.:..:..::.:|:|
Yeast   667 WTPQNGFVTSAQKLKRKDILNAVKDKVDAVYSS 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	LC_FACS_euk1	142..714	CDD:341294	227/611 (37%)
FAA1	NP_014962.3	LC_FACS_euk1	95..685	CDD:341294	227/611 (37%)
		Adenylate forming domain, Class I superfamily	<217..>281	CDD:473059	23/63 (37%)