DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and LACS8

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_178516.1	Gene:	LACS8 / 814974	AraportID:	AT2G04350	Length:	720	Species:	Arabidopsis thaliana

Alignment Length:	661	Identity:	275/661 - (41%)
Similarity:	410/661 - (62%)	Gaps:	14/661 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 TYRTTDPPRDVHVKMLQENIDTLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKKYNLG 142
            |.|....|..|.|..  |...|:..:|....|.|:..|.||||:.:.:|.....:||.|:|.:||
plant    63 TMRHARAPELVDVPW--EGAATMPALFEQSCKKYSKDRLLGTREFIDKEFITASDGRKFEKLHLG 125

  Fly   143 DYKWKTFTEAERTAANFGRGLRELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIVTVYATLGD 207
            :|||:::.|......||..||..:|....:.:.||::|||||.||..|||:|::.:||:||:||:
plant   126 EYKWQSYGEVFERVCNFASGLVNVGHNVDDRVAIFSDTRAEWFIAFQGCFRQSITVVTIYASLGE 190

  Fly   208 DGVAHCITETEVTTVITSHDLLPKFKTLLDKCPLVKTIIYIED---QLQKTETTGFKEGVKILPF 269
            :.:.:.:.||.|:|:|.....|.|...:......||.|||||:   .:..::.....: :.:...
plant   191 EALIYSLNETRVSTLICDSKQLKKLSAIQSSLKTVKNIIYIEEDGVDVASSDVNSMGD-ITVSSI 254

  Fly   270 NQVVKTGQDSKFEHVPPKGDDIAIIMYTSGSTGTPKGVLLSHKNCIATMKGFVDMVP-IYPDDVL 333
            ::|.|.||.:..:.:.|..:.:|:||:||||||.||||:::|.|.:||..|.:.:|| :..:|..
plant   255 SEVEKLGQKNAVQPILPSKNGVAVIMFTSGSTGLPKGVMITHGNLVATAAGVMKVVPKLDKNDTY 319

  Fly   334 IGFLPLAHVFELVAESVCLMTGVPIGYSTPLTLIDTSSKIKRGCKGDATVLKPTCMTSVPLILDR 398
            |.:|||||||||.||.|...:|..|||.:.:||.|||:|:|:|.|||.:.||||.||:||.||||
plant   320 IAYLPLAHVFELEAEIVVFTSGSAIGYGSAMTLTDTSNKVKKGTKGDVSALKPTIMTAVPAILDR 384

  Fly   399 ISKGINDKVNSGSAFKKSLFKFLYQYKVKWVQR------GYKTPLIDKLVFKKVAKLMGGKVRII 457
            :.:|:..||.......|:||.|.|:.::..|..      |.:..|.|.|||||:..::||.:|.:
plant   385 VREGVLKKVEEKGGMAKTLFDFAYKRRLAAVDGSWFGAWGLEKMLWDALVFKKIRAVLGGHIRFM 449

  Fly   458 MSGGAPLSADTHEQIKTCLCLELIQGYGLTETTSGATVMDYRDMTYGRTGGPLTVCDIRLVNWEE 522
            :.||||||.|:...|..|:...:.||||||||.:|||..::.|...||.|.||....::||:|||
plant   450 LVGGAPLSPDSQRFINICMGSPIGQGYGLTETCAGATFSEWDDPAVGRVGPPLPCGYVKLVSWEE 514

  Fly   523 GNYRVTNKPYPQGEVLIGGECVSQGYYKLPGKTNEDF-FEEDGQRWFKTGDIGEIQADGVLKIID 586
            |.||:::||.|:||:::||..|:.||:....||:|.: .:|.|.|||.|||||....||.|::||
plant   515 GGYRISDKPMPRGEIVVGGNSVTAGYFNNQEKTDEVYKVDEKGTRWFYTGDIGRFHPDGCLEVID 579

  Fly   587 RKKDLVKLQAGEYVSLGKVESELKTCGIIENICVYGDPTKQYTVALVVPNQNHLEELAQKHGLGD 651
            ||||:||||.||||||||||:.|.:...::||.|:.||...|.||||||::..||:.|::.|:..
plant   580 RKKDIVKLQHGEYVSLGKVEAALGSSNYVDNIMVHADPINSYCVALVVPSRGALEKWAEEAGVKH 644

  Fly   652 KSFEELCSSPIIEKAILKEIAEHARKCKLQKYEVPAAITLCKEVWSPDMGLVTAAFKLKRKDIQD 716
            ..|.|||......|.:.:.:.:..:..||:|:|:||.|.|..|.|:|:.||||||.|:||:.|:.
plant   645 SEFAELCEKGEAVKEVQQSLTKAGKAAKLEKFELPAKIKLLSEPWTPESGLVTAALKIKREQIKS 709

  Fly   717 RYQHDINRMYA 727
            :::.:::::||
plant   710 KFKDELSKLYA 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	268/642 (42%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	252/594 (42%)
LACS8	NP_178516.1	PLN02387	42..720	CDD:215217	273/659 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	398	1.000	Domainoid score	I138
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3278
Inparanoid	1	1.050	538	1.000	Inparanoid score	I266
OMA	1	1.010	-	-		QHG53493
OrthoDB	1	1.010	-	-		D293865at2759
OrthoFinder	1	1.000	-	-		FOG0001203
OrthoInspector	1	1.000	-	-		otm3246
orthoMCL	1	0.900	-	-		OOG6_100746
Panther	1	1.100	-	-	O	PTHR43272
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X593
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840