DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and Acsbg3

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_084417.1	Gene:	Acsbg3 / 78625	MGIID:	1925875	Length:	705	Species:	Mus musculus

Alignment Length:	782	Identity:	155/782 - (19%)
Similarity:	294/782 - (37%)	Gaps:	186/782 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 QDSRRV-KAKPINQKMLVDESKYAPDDIEAKIVRNDDNEL-----TYRTTDPPRDVHVKMLQENI 97
            |.|||: |.|.|.:..:        ....:|..:.|:.|:     :|.|:.....|.::|.::.:
Mouse    11 QTSRRILKTKTILKNKI--------HSAISKKAQADNFEILTPGSSYWTSKREGQVQLRMGKDPL 67

  Fly    98 D-----TLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKKYNLGDYKWKTFT-----EA 152
            |     |:..:....|..|:....:|::               :||      .|:..|     ||
Mouse    68 DNEPPVTVPDLIMSAATKYSHYLAIGSK---------------YKK------SWQLLTYIEYYEA 111

  Fly   153 ERTAANFGRGLRELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIVTVYATLGDDGVAHCITET 217
            .|.||   :...::|.:....:.|.....:||:||:.|........|.:.:::... ....|.||
Mouse   112 CRRAA---KAFLKVGLERFHGVGIMGINSSEWVIASIGAIMAGGISVGILSSISPK-ACQVIAET 172

  Fly   218 -EVTTVITSHD-LLPKFKTLLDKCPLVKTIIYIEDQLQKTETT-----GF---KEGVKILPFNQV 272
             |:...:..:| .|.|...:......:|.||...:.:|:.:..     ||   .:|:.....:::
Mouse   173 SEMDIFVVDNDRQLQKINQIQGYLKHLKAIIQYREDIQEAQPNLYSWKGFLDLADGISDEKLDKI 237

  Fly   273 VKTGQDSKFEHVPPKGDDIAIIMYTSGSTGTPKGVLLSHKNCIATMKGFVDMV----PIYPDDVL 333
            :.|          .|.:....::|..|:||..|.::|||.|...|....|..:    |....::|
Mouse   238 IDT----------LKPNQCCALVYNQGTTGPSKAIMLSHDNITWTTAAIVQSLGFKCPPQGQEIL 292

  Fly   334 IGFLPLA----HVFEL-VAESVC-----------LMTGVPIGYSTPLT--LIDTSSKIKRGCKGD 380
            :.:|||.    .:.:: ||.||.           ..:|:|   .||.|  |::...::
Mouse   293 VSYLPLCFPGIQILDVWVAISVAGTVYFPSLDSGKWSGLP---RTPGTGFLMELLREV------- 347

  Fly   381 ATVLKPTCMTSVPLILDRISKGINDKVNSGSAFKKSLFKFLYQYKVKWVQR-GYKT--------- 435
                :||....:|.:.||:...:..|....:||::.:        ..|..| |..|
Mouse   348 ----QPTTFCGIPWVWDRMLDSLKTKFLDSTAFRRRI--------DHWAMRMGLHTNKKLMMGEI 400

  Fly   436 ------PLIDKLVFKKVAKLMG-GKVRIIMSGGAPLSADTHEQIKTCLCLELIQGYGLTETTSGA 493
                  .|..:|.|::..|.:| ...:..::.|..|.:.|.:...: :.:.:::.|||:|.|...
Mouse   401 HQPLCFGLAKRLTFERARKFLGLNHCQQFLNMGMGLPSGTLDFFLS-VNIPIMELYGLSECTGLH 464

  Fly   494 TVMD---YRDMTYGRTGGPLTVCDIRLVNWEEGNYRVTNKPYPQGEVLIGGECVSQGYYKLPGKT 555
            ||.:   ||.::.|: ..|.|...:...| ::|          .|.:.|.|..:..||.:....|
Mouse   465 TVSNLQAYRILSAGK-ALPKTHTKVEKEN-KDG----------IGNLCIWGRHIFMGYLRDKQST 517

  Fly   556 NEDFFEEDGQRWFKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLGKVESELKT--------- 611
            ..   :.|...|..|.|:|.:..|..|.::....||:||.:||.|:...:|..::|
Mouse   518 ER---KVDTHGWLHTNDLGFLDFDKFLYVMGNNNDLIKLSSGEMVNPYPIEERVRTRIPIVRYAM 579

  Fly   612 ---------CGIIENICVYGDPTKQYTVALVVPNQNHLEEL--------AQKHGLGDKSFEELCS 659
                     |.::...|.....|.:       ...|...|:        :|...|.|..::.
Mouse   580 LVGQDAPYLCALLTLKCQINPETGE-------ARSNLTSEVVACCRKLRSQSTWLSDVLYDR--- 634

  Fly   660 SPIIEKAILKEIAEHARKCKLQKYEVPAAITLCKEVWSPDMGLVTAAFKLKRKDIQDRYQHDINR 724
            .|::.:.|.:.|.:...:......::...:.|..: :|.|.|.:....|:.|..:...||.:|.:
Mouse   635 DPLVTEFINQGIEDVNSEAPTMGAKIIKWVILDND-FSVDGGELGPMSKMNRSIVVKIYQEEIQK 698

  Fly   725 MY 726
            :|
Mouse   699 LY 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	141/720 (20%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	133/666 (20%)
Acsbg3	NP_084417.1	FAA1	74..701	CDD:223953	140/711 (20%)
Acsbg3	NP_084417.1	ACSBG_like	95..700	CDD:213299	135/688 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839116
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830