DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and Acsl3

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_001028778.2	Gene:	Acsl3 / 74205	MGIID:	1921455	Length:	720	Species:	Mus musculus

Alignment Length:	722	Identity:	347/722 - (48%)
Similarity:	459/722 - (63%)	Gaps:	38/722 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IKAIAFVYDIIT-LPVYLVLQKPWKRRQDSRRVKAKPINQKMLVDESKYAPDDIEAKIVRNDDNE 76
            |..|..:|.|:| :|.|.:.:   .:::...::||||::.|         ||.
Mouse    26 IHFIISLYTILTYIPFYFLCE---SKQEKPNQIKAKPVSSK---------PDS------------ 66

  Fly    77 LTYRTTDPPRDVHVKMLQENIDTLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKKYNL 141
             .||:.:.. |....:|....|||:|||.|....:.:||.||||:||:||||:|.||::|||..|
Mouse    67 -AYRSINSV-DGLASVLYPGCDTLDKVFMYAKNKFKNKRLLGTREILNEEDEIQPNGKIFKKVIL 129

  Fly   142 GDYKWKTFTEAERTAANFGRGLRELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIVTVYATLG 206
            |.|.|.::.:....|.:||.||:.|||||:.||.||.||||||||||..||.....:||:|||||
Mouse   130 GHYNWLSYEDVFIRALDFGNGLQMLGQKPKANIAIFCETRAEWMIAAQACFMYNFQLVTLYATLG 194

  Fly   207 DDGVAHCITETEVTTVITSHDLL-PKFKTLLDKCPLVKTIIYIEDQLQKTET-TGFKEGVKILPF 269
            ...:.|.:.|||||.:|||.:|| .|.|.::...|.::.||.::.   |..| :.|.:||.:...
Mouse   195 GPAIVHGLNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDG---KPPTWSEFPKGVIVHTM 256

  Fly   270 NQVVKTGQDSKFE---HVPPKGDDIAIIMYTSGSTGTPKGVLLSHKNCIATMKGFVDMVP-IYPD 330
            ..|...|..:..|   |..|...|||:|||||||||.||||::||.|.||::.|....:| :..:
Mouse   257 AAVQALGVKANVEKKAHSKPLPSDIAVIMYTSGSTGIPKGVMISHSNIIASITGMARRIPRLGEE 321

  Fly   331 DVLIGFLPLAHVFELVAESVCLMTGVPIGYSTPLTLIDTSSKIKRGCKGDATVLKPTCMTSVPLI 395
            ||.||:||||||.||.||.|||..|..||||:|.||.|.|||||:|.|||.:|||||.|.:||.|
Mouse   322 DVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSVLKPTLMAAVPEI 386

  Fly   396 LDRISKGINDKVNSGSAFKKSLFKFLYQYKVKWVQRGYKTPLIDKLVFKKVAKLMGGKVRIIMSG 460
            :|||.|.:.:|||..|||:::||...|.||::.:.:|..|||.|:.||:.|.:|:||.:|:::.|
Mouse   387 MDRIYKNVMNKVNEMSAFQRNLFILAYNYKMEQISKGCSTPLCDRFVFRNVRRLLGGNIRLLLCG 451

  Fly   461 GAPLSADTHEQIKTCLCLELIQGYGLTETTSGATVMDYRDMTYGRTGGPLTVCDIRLVNWEEGNY 525
            ||||||.|...:..|.|..:.|||||||:|...|:.:..|...||.|.||..|:|:|.|||||.|
Mouse   452 GAPLSATTQRFMNICFCCPVGQGYGLTESTGAGTITEVWDYNTGRVGAPLVCCEIKLKNWEEGGY 516

  Fly   526 RVTNKPYPQGEVLIGGECVSQGYYKLPGKTNEDFFE-EDGQRWFKTGDIGEIQADGVLKIIDRKK 589
            ..|:||:|:||:||||:.|:.||||...||..|||| |:||||..||||||...||.||||||||
Mouse   517 FNTDKPHPRGEILIGGQNVTMGYYKNEAKTKTDFFEDENGQRWLCTGDIGEFDPDGCLKIIDRKK 581

  Fly   590 DLVKLQAGEYVSLGKVESELKTCGIIENICVYGDPTKQYTVALVVPNQNHLEELAQKHGLGDKSF 654
            |||||||||||||||||:.||...:|:|||.|.:....|.:..|||||..|.|||:..|. ..::
Mouse   582 DLVKLQAGEYVSLGKVEAALKNLPLIDNICAYANSYHSYVIGFVVPNQKELTELARTKGF-KGTW 645

  Fly   655 EELCSSPIIEKAILKEIAEHARKCKLQKYEVPAAITLCKEVWSPDMGLVTAAFKLKRKDIQDRYQ 719
            ||||:|..:|..:||.::|.|....|:|:|:|..|.|..:.|:|:.||||.|||||||:::..||
Mouse   646 EELCNSSEMENEVLKVLSEAAISASLEKFEIPLKIRLSPDPWTPETGLVTDAFKLKRKELKTHYQ 710

  Fly   720 HDINRMY 726
            .||.|||
Mouse   711 ADIERMY 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	329/639 (51%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	301/590 (51%)
Acsl3	NP_001028778.2	PLN02387	30..717	CDD:215217	343/716 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	453	1.000	Domainoid score	I504
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3278
Inparanoid	1	1.050	639	1.000	Inparanoid score	I820
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53493
OrthoDB	1	1.010	-	-		D141523at33208
OrthoFinder	1	1.000	-	-		FOG0001203
OrthoInspector	1	1.000	-	-		otm42384
orthoMCL	1	0.900	-	-		OOG6_100746
Panther	1	1.100	-	-	O	PTHR43272
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R654
SonicParanoid	1	1.000	-	-		X593
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.870