DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and acsl6

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_021324602.1	Gene:	acsl6 / 566863	ZFINID:	ZDB-GENE-030131-6776	Length:	674	Species:	Danio rerio

Alignment Length:	729	Identity:	205/729 - (28%)
Similarity:	319/729 - (43%)	Gaps:	124/729 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IGAIKAIAFVYDIITLPVYLVLQKPWKRRQDSRRVKAKP-INQKMLVDESKYAPDDIEAKIVRND 73
            :||:.|: ..|.|...|..:|  .|...|..|..|:.:. ..:.|:.|.||.
Zfish    57 LGALTAV-LAYWITKRPRAIV--PPCDLRHQSLEVQMEDGARRSMMGDRSKL------------- 105

  Fly    74 DNELTYRTTDPPRDVHVKMLQENIDTLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKK 138
               |.|             ..|:..|:.:||............||:|  |..:
Zfish   106 ---LAY-------------YHEDAKTMYEVFQRGLHITGDGPFLGSR--LPNQ------------ 140

  Fly   139 YNLGDYKWKTFTEAERTAANFGRGLRELGQKPREN--IVIFAETRAEWMIAAHGCFKQAMPIVTV 201
                .|.|.::.|....|...|.||...|.:|..:  |.:||:.|.||:|:...|:..:|.:|.:
Zfish   141 ----PYTWLSYREVSTRAEYVGSGLLSQGCQPNTDQLIGVFAQNRPEWIISELACYTYSMVVVPL 201

  Fly   202 YATLGDDGVAHCITETEVTTVITSHDLLPKFKTLLD-----KCPLVKTIIYIEDQLQKTETTGFK 261
            |.|||.|.:...|...|::|||.  |...|...||:     :.|.:|.||.::....:....|.|
Zfish   202 YDTLGADAIRFIINTAEISTVIC--DKAEKAVVLLENVQRGETPGLKMIILMDTFDSQLLEEGQK 264

  Fly   262 EGVKILPFNQVVKTGQDSKFEHVPPKGDDIAIIMYTSGSTGTPKGVLLSHKNCIATMKGFVDMVP 326
            .||.|.....|...|:::....|||..||::|:.:|||:|| .|.|::.|...|...:|.:.::|
Zfish   265 CGVHIQALRDVEALGRENHRTPVPPSPDDLSIVCFTSGTTG-QKAVVICHGGRIGFFQGDIRLLP 328

  Fly   327 IYPDDVLIGFLPLAHVFELVAESVCLMTGVPIGYSTPLTLIDTSSKIKRGCKGDATVLKPTCMTS 391
                                                                .|...|:||....
Zfish   329 ----------------------------------------------------DDMKALRPTIFPV 341

  Fly   392 VPLILDRISKGINDKVNSGSAFKKSLFKFLYQYKVKWVQRGY--KTPLIDKLVFKKVAKLMGGKV 454
            ||.:|:|:...|..:.|  ::.|:.|..|..:.|...|.||.  ...:.||:.|.|:...:||::
Zfish   342 VPRLLNRMYDKIFSQAN--NSVKRWLLNFAAKRKGAEVSRGVTRSDSIWDKIFFHKIQASLGGRL 404

  Fly   455 RIIMSGGAPLSADTHEQIKTCLCLELIQGYGLTETTSGATVMDYRDMTYGRTGGPLTVCDIRLVN 519
            |:|::|.||.|....:.::..|..::.:.||.||.|:|.|.....|.|.|..|.||....|:||:
Zfish   405 RMIITGAAPASPSVLDFLRAALGCQVYEAYGQTECTAGCTFTTPGDWTSGHVGAPLPCNLIKLVD 469

  Fly   520 WEEGNYRVTNKPYPQGEVLIGGECVSQGYYKLPGKTNEDFFEEDGQRWFKTGDIGEIQADGVLKI 584
            ..|.||....   .:||:.:.|..|.:||.|.|.:|.|..   |...|..|||||:..|:|.|||
Zfish   470 VAEKNYFAAK---GEGEICVKGPNVFKGYLKDPVRTAETL---DADGWLHTGDIGKWLANGTLKI 528

  Fly   585 IDRKKDLVKLQAGEYVSLGKVESELKTCGIIENICVYGDPTKQYTVALVVPNQNHLEELAQKHGL 649
            |||||.:.||..|||:|..|:||.......:..:.|:||..:...|.::||:.......|||.|.
Zfish   529 IDRKKHIFKLAQGEYISPEKIESIYIRSEPVSQLYVHGDSLQSCLVGIIVPDPEVFPSWAQKKGF 593

  Fly   650 GDKSFEELCSSPIIEKAILKEIAEHARKCKLQKYEVPAAITLCKEVWSPDMGLVTAAFKLKRKDI 714
             |..|.|||.:..::||||:::....:...|..:|....|.:.||::|.:.||:|...|.||.::
Zfish   594 -DGGFHELCENKELKKAILEDMVRLGKASGLHSFEQVKDIYIHKEMFSIENGLLTPTLKAKRPEL 657

  Fly   715 QDRYQHDINRMYAS 728
            ::.::.:|..:|:|
Zfish   658 KEYFKEEIQDLYSS 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	186/640 (29%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	178/592 (30%)
acsl6	XP_021324602.1	LC-FACS_euk	140..669	CDD:213293	178/608 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910