DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and acsl1a

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_001027007.1	Gene:	acsl1a / 555308	ZFINID:	ZDB-GENE-050809-115	Length:	697	Species:	Danio rerio

Alignment Length:	680	Identity:	210/680 - (30%)
Similarity:	338/680 - (49%)	Gaps:	54/680 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PDDIEAKIVRNDDNELTYRTTDPPRDVHVKMLQENIDTLEKVFNYVAKTYTSKRCLGTRQILSEE 126
            |.|:..:.|.....|...|:.....|.|:....::..||.:.|....:...:..|||:|:.
Zfish    54 PCDLTMQSVEVPGKEYARRSILMDNDTHMTYYYKDALTLYEFFLRGLRVPNNGPCLGSRKA---- 114

  Fly   127 DEVQQNGRVFKKYNLGDYKWKTFTEAERTAANFGRGLRELG--QKPRENIVIFAETRAEWMIAAH 189
                  |:        .|||.::.|....|...|..|...|  |...:.|.|||:.|.||.|:..
Zfish   115 ------GQ--------PYKWLSYKEVADRAEFAGSALLHRGHSQSGDKYIGIFAQNRPEWTISEL 165

  Fly   190 GCFKQAMPIVTVYATLGDDGVAHCITETEVTTVITSHDLLPKFKTLLD----KCPLVKTIIYIED 250
            .|:..::..|.:|.|||.:.:::.|.:..:||:|.  |:..|.:.:||    :...|.||:.:|.
Zfish   166 ACYTYSLVAVPLYDTLGTEAISYVIDKASITTIIC--DIADKARLILDCVSGRKHSVTTIVIMES 228

  Fly   251 QLQKTETTGFKEGVKILPFNQVVKTGQDSKFEHVPPKGDDIAIIMYTSGSTGTPKGVLLSHKNCI 315
            ...:........|:.|:...::...|:.:....:|||.:|:|:|.:|||:||.|||.:|:|.|.:
Zfish   229 FDSELTAQAQNCGIDIISLKELEAIGKANHKTPIPPKPEDLALICFTSGTTGNPKGAMLTHGNVV 293

  Fly   316 ATMKGFVDMVPIY----PDDVLIGFLPLAHVFELVAESVCLMTGVPIGY--STPLTLIDTSSKIK 374
            :....|:.:..::    ..|:.|.:|||||:||.|.|.|.|..|..|||  .....|:|
Zfish   294 SNCSAFIKITEVHCMLNQTDIHISYLPLAHMFERVVEGVLLCHGAKIGYFQGDIRLLMD------ 352

  Fly   375 RGCKGDATVLKPTCMTSVPLILDRISKGINDKVNSGSAFKKSLFKFLYQYKVKWVQRGY--KTPL 437
                 |...||||....||.:|:|:...|..:.|  :..|:.|..|....|...::.|.  |..:
Zfish   353 -----DLKNLKPTIFPVVPRLLNRMFDKIFGQAN--TPLKRWLLDFATSRKEAELKSGVVRKDSM 410

  Fly   438 IDKLVFKKVAKLMGGKVRIIMSGGAPLSADTHEQIKTCLCLELIQGYGLTETTSGATVMDYRDMT 502
            .|||:|.||...:||:||::::|.||:|......::..|..:..:|||.||.|:|.|:....|.|
Zfish   411 WDKLIFSKVQASLGGRVRLMITGAAPVSPTVLTFLRAALGCQFYEGYGQTECTAGCTMSLPGDWT 475

  Fly   503 YGRTGGPLTVCDIRLVNWEEGNYRVTNKPYPQGEVLIGGECVSQGYYKLPGKTNEDFFEEDGQRW 567
            .|..|.||....::||:..|.||...|   .:|||.:.|..|.|||.|.|.:|:.   ..|...|
Zfish   476 AGHVGAPLPCNFVKLVDVAEMNYFAAN---GEGEVCVKGPNVFQGYLKDPEQTSG---AVDKAGW 534

  Fly   568 FKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLGKVESELKTCGIIENICVYGDPTKQYTVAL 632
            ..|||||:...:|.||||||||.:.||..|||::..|:|:.......:..:.|:||..:...|.:
Zfish   535 LHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYIRSDPVAQVFVHGDSLQACLVGV 599

  Fly   633 VVPNQNHLEELAQKHGLGDKSFEELCSSPIIEKAILKEIAEHARKCKLQKYEVPAAITLCKEVWS 697
            |||:.:.|...|:..|: :.||.:||.|..::.|||:::.:..::..|:.:|....|.|..|::|
Zfish   600 VVPDPDFLPGWAKNRGI-EGSFNDLCKSKEVKNAILEDMIQLGKEAGLKSFEQVRDIALHLEMFS 663

  Fly   698 PDMGLVTAAFKLKRKDIQDRYQHDINRMYA 727
            ...||:|...|.||.:::.|::..|:::||
Zfish   664 VQNGLLTPTLKAKRTELKSRFREQIDQLYA 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	201/645 (31%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	193/597 (32%)
acsl1a	NP_001027007.1	PLN02736	88..695	CDD:178337	203/646 (31%)
acsl1a	NP_001027007.1	LC-FACS_euk	116..692	CDD:213293	193/605 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53493
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820