DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and ACSL5

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_057318.2	Gene:	ACSL5 / 51703	HGNCID:	16526	Length:	739	Species:	Homo sapiens

Alignment Length:	661	Identity:	209/661 - (31%)
Similarity:	327/661 - (49%)	Gaps:	71/661 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 QENID----------TLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKKYNLGDYKWKT 148
            |:|.|          |:.:||........:..|||                 ::|.| ..|:|.:
Human   117 QKNNDLTSCCFSDAKTMYEVFQRGLAVSDNGPCLG-----------------YRKPN-QPYRWLS 163

  Fly   149 FTEAERTAANFGRGLRELGQK--PRENIVIFAETRAEWMIAAHGCFKQAMPIVTVYATLGDDGVA 211
            :.:....|...|..|...|.|  |.:.:.|||:.|.||:|:...|:..:|..|.:|.|||.:.:.
Human   164 YKQVSDRAEYLGSCLLHKGYKSSPDQFVGIFAQNRPEWIISELACYTYSMVAVPLYDTLGPEAIV 228

  Fly   212 HCITETEVTTVITSHDLLPKFKTLLDK-----CPLVKTIIYIEDQLQKTETTGFKEGVKILPFNQ 271
            |.:.:.::..||.  |...|...|:..     .|.:|.||.::......:..|.|.|::||....
Human   229 HIVNKADIAMVIC--DTPQKALVLIGNVEKGFTPSLKVIILMDPFDDDLKQRGEKSGIEILSLYD 291

  Fly   272 VVKTGQDSKFEHVPPKGDDIAIIMYTSGSTGTPKGVLLSHKNCIATMKGFVDMV-----PIYPDD 331
            ....|::...:.|||..:|:::|.:|||:||.|||.:::|:|.::....|:..|     |. |||
Human   292 AENLGKEHFRKPVPPSPEDLSVICFTSGTTGDPKGAMITHQNIVSNAAAFLKCVEHAYEPT-PDD 355

  Fly   332 VLIGFLPLAHVFELVAESVCLMTGVPIG-YSTPLTLIDTSSKIKRGCKGDATVLKPTCMTSVPLI 395
            |.|.:|||||:||.:.::|....|..:| :...:.|:          ..|...||||...:||.:
Human   356 VAISYLPLAHMFERIVQAVVYSCGARVGFFQGDIRLL----------ADDMKTLKPTLFPAVPRL 410

  Fly   396 LDRISKGINDKV--NSGSAFKKSLFKFLYQYKVKWVQRGY--KTPLIDKLVFKKVAKLMGGKVRI 456
            |:|    |.|||  .:.:..||.|.|.....|.|.:|:|.  .....|||:|.|:...:||:||:
Human   411 LNR----IYDKVQNEAKTPLKKFLLKLAVSSKFKELQKGIIRHDSFWDKLIFAKIQDSLGGRVRV 471

  Fly   457 IMSGGAPLSADTHEQIKTCLCLELIQGYGLTETTSGATVMDYRDMTYGRTGGPLTVCDIRLVNWE 521
            |::|.||:|.......:..:..::.:.||.||.|.|.|.....|.|.|..|.||....::|.:..
Human   472 IVTGAAPMSTSVMTFFRAAMGCQVYEAYGQTECTGGCTFTLPGDWTSGHVGVPLACNYVKLEDVA 536

  Fly   522 EGNYRVTNKPYPQGEVLIGGECVSQGYYKLPGKTNEDFFEEDGQRWFKTGDIGEIQADGVLKIID 586
            :.||...|.   :|||.|.|..|.:||.|.|.||.| ..:.||  |..|||||....:|.|||||
Human   537 DMNYFTVNN---EGEVCIKGTNVFKGYLKDPEKTQE-ALDSDG--WLHTGDIGRWLPNGTLKIID 595

  Fly   587 RKKDLVKLQAGEYVSLGKVESELKTCGIIENICVYGDPTKQYTVALVVPNQNHLEELAQKHGLGD 651
            |||::.||..|||::..|:|:.......:..|.|:|:..:...|.:|||:.:.|...|.|  ||.
Human   596 RKKNIFKLAQGEYIAPEKIENIYNRSQPVLQIFVHGESLRSSLVGVVVPDTDVLPSFAAK--LGV 658

  Fly   652 K-SFEELCSSPIIEKAILKEIAEHARKCKLQKYEVPAAITLCKEVWSPDMGLVTAAFKLKRKDIQ 715
            | ||||||.:.::.:|||:::.:..::..|:.:|...||.|..|.:|.:.||:|...|.||.::.
Human   659 KGSFEELCQNQVVREAILEDLQKIGKESGLKTFEQVKAIFLHPEPFSIENGLLTPTLKAKRGELS 723

  Fly   716 DRYQHDINRMY 726
            ..::..|:.:|
Human   724 KYFRTQIDSLY 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	208/660 (32%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	197/601 (33%)
ACSL5	NP_057318.2	PLN02736	127..737	CDD:178337	206/651 (32%)
ACSL5	NP_057318.2	LC-FACS_euk	157..734	CDD:213293	197/601 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53493
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820