DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and acsl1b

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_001003569.1	Gene:	acsl1b / 445175	ZFINID:	ZDB-GENE-040801-88	Length:	697	Species:	Danio rerio

Alignment Length:	683	Identity:	206/683 - (30%)
Similarity:	345/683 - (50%)	Gaps:	56/683 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 APDDIEAKIVRNDDNELTYRTTDPPRDVHVKMLQENIDTLEKVFNYVAKTYTSKRCLGTRQILSE 125
            ||.|:..:.:.....|...|.........:....|:..|:.:.|:...:...:..|||:|:...
Zfish    53 APCDLRMQSIELPGGEFARRGAVLNGGPLLSFYYEDAKTMYECFHRGLRESKNGPCLGSRKPKQ- 116

  Fly   126 EDEVQQNGRVFKKYNLGDYKWKTFTEAERTAANFGRGLRELGQKPREN--IVIFAETRAEWMIAA 188
                             .|:|.:::|....|.:.|......|.....:  |.||::.|.||.||.
Zfish   117 -----------------PYEWLSYSEVIERAEHLGSAFLHKGHSKSGDPYIGIFSQNRPEWTIAE 164

  Fly   189 HGCFKQAMPIVTVYATLGDDGVAHCITETEVTTVITSHDLLPKFKTLLDKC-----PLVKTIIYI 248
            ..|:..::..|.:|.|||.:.:::.:.:|.::||:..   :|:...||.:|     ..|||:|.:
Zfish   165 LACYTYSLISVPLYDTLGTEAISYILDKTCISTVVCD---VPEKAGLLLECVSGRQHSVKTLILM 226

  Fly   249 EDQLQKTETTGFKEGVKILPFNQVVKTGQDSKFEHVPPKGDDIAIIMYTSGSTGTPKGVLLSHKN 313
            .|.....::...:.|::|:........|:..:.:..||:.||:|:|.:|||:||.|||.:|:|:|
Zfish   227 ADVDADLQSRAQQCGIQIISLTDAENMGKTHRRQPEPPQPDDLAVICFTSGTTGNPKGAMLTHRN 291

  Fly   314 CIATMKGFVDMV----PIYPDDVLIGFLPLAHVFELVAESVCLMTGVPIGY--STPLTLIDTSSK 372
            .::.:..|:.:.    |:...|..|.:|||||:||.|.:.|.|:.|..|||  .....|:|
Zfish   292 IVSNISAFIHVTNSTCPLSSRDSHISYLPLAHMFERVVQGVVLLHGARIGYFQGDIRVLMD---- 352

  Fly   373 IKRGCKGDATVLKPTCMTSVPLILDRISKGINDKVNSGSAFKKSLFKFLYQYKVKWVQRGY--KT 435
                   |...||||....||.:|:|:...|..:.|  :..|:.|.:|.::.|...::.|.  :.
Zfish   353 -------DLIALKPTIFPVVPRLLNRMFDKIYGQAN--TPLKRRLLEFAFRRKEAEMKSGIMRRD 408

  Fly   436 PLIDKLVFKKVAKLMGGKVRIIMSGGAPLSADTHEQIKTCLCLELIQGYGLTETTSGATVMDYRD 500
            .:.||::||||...:||.||::::|.||:|......::..|..:..:|||.||.|:|:|.....|
Zfish   409 SIWDKIIFKKVQASVGGCVRMMVTGAAPISEPVLTFLRAALGCQFYEGYGQTECTAGSTTTLPGD 473

  Fly   501 MTYGRTGGPLTVCDIRLVNWEEGNYRVTNKPYPQGEVLIGGECVSQGYYKLPGKTNEDFFEEDGQ 565
            .|.|..|.||...||:||:..|.||...|   .:|||.:.|....:||.|.|.||.|...||.
Zfish   474 WTAGHVGAPLPCNDIKLVDVAEMNYYAAN---GEGEVCVRGPNAFKGYLKDPEKTKEALDEEG-- 533

  Fly   566 RWFKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLGKVESELKTCGIIENICVYGDPTKQYTV 630
             |..|||||....:|.|||:||||.:.||..|||::..|:|:.......:....|:||..:...|
Zfish   534 -WVHTGDIGRWLPNGSLKIVDRKKHIFKLAQGEYIAPEKIENIYIRSEAVVQAFVHGDSLQACLV 597

  Fly   631 ALVVPNQNHLEELAQKHGLGDKSFEELCSSPIIEKAILKEIAEHARKCKLQKYEVPAAITLCKEV 695
            |::||:.:.|...|:|.|: :.::|:||.:..|:||||::|.:..::..|:.:|....|.|..|:
Zfish   598 AIIVPDPDFLPGWAKKRGI-EGTYEDLCKNKDIKKAILEDIIKLGKESGLKSFEQVKDIALHSEM 661

  Fly   696 WSPDMGLVTAAFKLKRKDIQDRYQHDINRMYAS 728
            ::...||:|...|.||.|:::.::..|:.:||:
Zfish   662 FTIQNGLLTPTLKAKRADLRNHFRSHIDELYAN 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	199/646 (31%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	192/598 (32%)
acsl1b	NP_001003569.1	PLN02736	88..695	CDD:178337	200/648 (31%)
acsl1b	NP_001003569.1	LC-FACS_euk	116..692	CDD:213293	192/616 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53493
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820