DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and acsl4a

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_956943.1	Gene:	acsl4a / 393622	ZFINID:	ZDB-GENE-040426-1565	Length:	706	Species:	Danio rerio

Alignment Length:	722	Identity:	324/722 - (44%)
Similarity:	472/722 - (65%)	Gaps:	37/722 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IKAIAFVYDIITLPVYLVLQKPWKRRQDSRRVKAKPINQKMLVDESKYAPDDIEAKIVRNDDNEL 77
            :.|:.::|.:::...:..|....:::..::|:|:|..:.:         ||.
Zfish    11 VHAVVWLYSLLSFLPWYFLTGAQEKKALAKRLKSKSTSDQ---------PDG------------- 53

  Fly    78 TYRTTDPPRDVHVKMLQENIDTLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKKYNLG 142
            .||:||....: |.:.....|||:|:|:|..:.:....|||||::||.::|.|.||:||||..||
Zfish    54 PYRSTDRFESL-VTVDFPGKDTLDKLFDYAVERFGKLDCLGTREVLSGDNETQPNGKVFKKLILG 117

  Fly   143 DYKWKTFTEAERTAANFGRGLRELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIVTVYATLGD 207
            :||||::.|.:...::||.||..|||:|:..|.||.||||||||.|..||::..|:||.|||||:
Zfish   118 EYKWKSYEELDIEVSHFGSGLAALGQQPKSTIAIFCETRAEWMITAQACFRRNFPLVTFYATLGE 182

  Fly   208 DGVAHCITETEVTTVITSHDLL-PKFKTLLDKCPLVKTIIYIEDQLQKTETTGFKEGVKILPFNQ 271
            |.||:.:.|:.||.::||.:|| .|.|::|.:.|.:|.|||::.  :...|.||.:|::|...:.
Zfish   183 DAVAYGLNESGVTHLVTSIELLETKLKSVLLQIPNLKHIIYVDS--KSMNTAGFPQGIQIHSMHS 245

  Fly   272 VVKTGQDSKFEH-----VPPKGDDIAIIMYTSGSTGTPKGVLLSHKNCIATMKGFVDMVP-IYPD 330
            |.:.|  :|.|:     |.|...|:|:|||||||||.||||::.|.|.|..|.|..:.:| :.|.
Zfish   246 VEELG--AKPENLNRPIVKPVPSDLAVIMYTSGSTGRPKGVMIIHSNLIGGMAGQCERIPGLGPK 308

  Fly   331 DVLIGFLPLAHVFELVAESVCLMTGVPIGYSTPLTLIDTSSKIKRGCKGDATVLKPTCMTSVPLI 395
            |..|.:||||||.|:.||..|:..|..||||:|.||.|.|:|||:|.|||.:||||:.|.:||.|
Zfish   309 DTYIAYLPLAHVLEMTAEISCVTYGCRIGYSSPQTLSDQSTKIKKGSKGDCSVLKPSLMAAVPEI 373

  Fly   396 LDRISKGINDKVNSGSAFKKSLFKFLYQYKVKWVQRGYKTPLIDKLVFKKVAKLMGGKVRIIMSG 460
            :|||:|.:..||...|..:::|||..|.||::.:::||..||.: ::||||..|:||.||:::||
Zfish   374 MDRINKNVMSKVQEMSCVQRTLFKPAYDYKLEQIKKGYDAPLCN-ILFKKVRALLGGNVRMMLSG 437

  Fly   461 GAPLSADTHEQIKTCLCLELIQGYGLTETTSGATVMDYRDMTYGRTGGPLTVCDIRLVNWEEGNY 525
            |||||..|...:..|.|..:.||||||||....|:.:..|.:.||.|.||..|:::|.:|.||.|
Zfish   438 GAPLSPATQRFMNICFCCPVGQGYGLTETCGAGTITEVADYSTGRVGAPLICCEVKLKDWAEGGY 502

  Fly   526 RVTNKPYPQGEVLIGGECVSQGYYKLPGKTNEDFF-EEDGQRWFKTGDIGEIQADGVLKIIDRKK 589
            ...:||:|:||:||||..|:.|||:..|..|:||| :::|||||.||||||:.|||.|:|:||||
Zfish   503 TKRDKPHPRGEILIGGPNVTMGYYRTEGCNNDDFFVDQNGQRWFCTGDIGEMHADGCLQIVDRKK 567

  Fly   590 DLVKLQAGEYVSLGKVESELKTCGIIENICVYGDPTKQYTVALVVPNQNHLEELAQKHGLGDKSF 654
            ||||||||||||||||||.||.|..::|||.|.:..:.|.::.:||||..|..||.:.|: :.::
Zfish   568 DLVKLQAGEYVSLGKVESALKNCSFVDNICAYANSDQNYVISFIVPNQKKLTALANQKGI-EGTW 631

  Fly   655 EELCSSPIIEKAILKEIAEHARKCKLQKYEVPAAITLCKEVWSPDMGLVTAAFKLKRKDIQDRYQ 719
            ||:|:.|::|:.:|:||.|.|...|||::|:|..:.|..|.|:|:.||||.|||||||::::.|.
Zfish   632 EEICNHPVMEREVLREIKEVANSIKLQRFEIPVMVHLSPEPWTPETGLVTDAFKLKRKELKNHYL 696

  Fly   720 HDINRMY 726
            :||.|||
Zfish   697 NDIERMY 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	311/640 (49%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	287/591 (49%)
acsl4a	NP_956943.1	PLN02387	60..703	CDD:215217	310/649 (48%)
acsl4a	NP_956943.1	LC-FACS_euk	117..703	CDD:213293	287/591 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	446	1.000	Domainoid score	I504
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	636	1.000	Inparanoid score	I804
OMA	1	1.010	-	-		QHG53493
OrthoDB	1	1.010	-	-		D141523at33208
OrthoFinder	1	1.000	-	-		FOG0001203
OrthoInspector	1	1.000	-	-		otm24969
orthoMCL	1	0.900	-	-		OOG6_100746
Panther	1	1.100	-	-	LDO	PTHR43272
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R654
SonicParanoid	1	1.000	-	-		X593
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870