Protein Alignment Acsl and hll

DIOPT Version :10

• Sequence 1: NP_001260810.1
• Gene: Acsl / 46068
• FlyBaseID: FBgn0263120
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: NP_609696.1
• Gene: hll / 34822
• FlyBaseID: FBgn0286723
• Length: 681
• Species: Drosophila melanogaster
• Alignment Length: 742
• Identity: 169/742 - (22%)
• Similarity: 288/742 - (38%)
• Gaps: 174/742 - (23%)

  Fly    74 DNELTYRTTDPPRDVHVKMLQENIDTLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKK 138
            |...::..|.||:            |:.:.|....:.|:....|                 |::.
  Fly    24 DEPSSFSQTVPPQ------------TIPEFFKESCEKYSDLPAL-----------------VWET 59

  Fly   139 YNLGDYKWKTFT--EAERTAANFGRGLRELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIVTV 201
            ...|:..|.|.|  |.:.........|..:|.:.|.::.|.|....||..|..|..:....:..|
  Fly    60 PGSGNDGWTTLTFGEYQERVEQAALMLLSVGVEERSSVGILAFNCPEWFFAEFGALRAGAVVAGV 124

  Fly   202 YATLGDDGVAHCITETEVTT-VITSHDLLPKFKTLLDKCPLVKTIIYIEDQL------------- 252
            |.:...:.|.|.:...|.:. |:.....:.|.:.:.::.|.:|.:|.:....
  Fly   125 YPSNSAEAVHHVLATGESSVCVVDDAQQMAKLRAIKERLPRLKAVIQLHGPFEAFVDHEPGYFSW 189

  Fly   253 QKTETTGFKEGVKILPFNQVVKTGQDSKFEHVPPKGDDIAIIMYTSGSTGTPKGVLLSHKNCIAT 317
            ||.:...|...:|    .:::  .::|:.     :.::.|::::|||:.|.||.|:|||.|.:..
  Fly   190 QKLQEQTFSSELK----EELL--ARESRI-----RANECAMLIFTSGTVGMPKAVMLSHDNLVFD 243

  Fly   318 MKGFVDMVPIYPDDVLIG------FLPLAHVFELVAESVCLMTGVPIGYSTPLTLIDTSSKIKRG 376
            .|.    ...:..|:.:|      :|||:||   .|:...:..|  :.::..:|..|     |..
  Fly   244 TKS----AAAHMQDIQVGKESFVSYLPLSHV---AAQIFDVFLG--LSHAGCVTFAD-----KDA 294

  Fly   377 CKGDATVLK------PTCMTSVPLILDRISKGINDKVNSGSAFKKSLFKFLYQYKVKWVQRGYKT 435
            .||  |::|      ||.|..||    |:.:.:.:::.:..|..:...:.|.......|.....|
  Fly   295 LKG--TLIKTFRKARPTKMFGVP----RVFEKLQERLVAAEAKARPYSRLLLARARAAVAEHQTT 353

  Fly   436 PLIDK--------------LVFKKVAKLMG-GKVRIIMSGGAPLSADTHEQIKT-CLCLELIQG- 483
            .:..|              .|.|.:.:::| ...|:..:||||    |.|::|. .|.|::..|
  Fly   354 LMAGKSPSIYGNAKYWLACRVVKPIREMIGVDNCRVFFTGGAP----TSEELKQFFLGLDIALGE 414

  Fly   484 -YGLTETTSGATVMDYRDMTYGRTGGPLTVCDIRLVNWEEGNYRVTNKPYP-----QGEVLIGGE 542
             ||::| ||||..::. |::...:.|  ..|        ||   ||.|.:.     |||:|:.|.
  Fly   415 CYGMSE-TSGAITLNV-DISNLYSAG--QAC--------EG---VTLKIHEPDCNGQGEILMRGR 464

  Fly   543 CVSQGYYKLPGKTNEDFFEEDGQRWFKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLGKVES 607
            .|..||..||.|| |:..:|||  |..:||:|.|...|.|.|..|.|:|:....||.:....:|.
  Fly   465 LVFMGYLGLPDKT-EETVKEDG--WLHSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHIEE 526

  Fly   608 ELK---TCGIIENICVYGDPTKQYTVALVVPNQNHLEELAQKHGLGDKSFE-------------E 656
            .:|   .|  :.|:.:.||..|..||.|.:..:...:.......|.:::.|             |
  Fly   527 LIKKELPC--VSNVLLIGDHRKYLTVLLSLKTKCDAKTGIPLDALREETIEWLRDLDIHETRLSE 589

  Fly   657 LCSSP-----------------IIEKAILKEIAEHARKCKLQKYEVPAA-----ITLCKEVWSPD 699
            |.:.|                 |..|..|.|..|...| :..||.:..|     ..|....:|..
  Fly   590 LLNIPADLQLPNDTAALAATLEITAKPKLLEAIEEGIK-RANKYAISNAQKVQKFALIAHEFSVA 653

  Fly   700 MGLVTAAFKLKRKDIQDRYQHDINRMY 726
            .|.:....|::|..:..:|...|.|:|
  Fly   654 TGELGPTLKIRRNIVHAKYAKVIERLY 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	LC_FACS_euk1	142..714	CDD:341294	156/660 (24%)
hll	NP_609696.1	Adenylate forming domain, Class I superfamily	62..680	CDD:473059	159/673 (24%)