DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and acsbg2

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_001119851.1	Gene:	acsbg2 / 335159	ZFINID:	ZDB-GENE-030131-7099	Length:	752	Species:	Danio rerio

Alignment Length:	718	Identity:	160/718 - (22%)
Similarity:	277/718 - (38%)	Gaps:	148/718 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 TTDPPRDVHVKMLQENID-----TLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKKYN 140
            ||....:|.::|.:..:.     |:.::|....:.:.|...||.::
Zfish    95 TTHRDGEVKLRMAESGLGAETPLTVNQMFTSTVQRFGSYPALGWKE------------------- 140

  Fly   141 LGDYKWKTFTEAE-----RTAANFGRGLRELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIVT 200
             |: :|||.|.:|     ||||   :...:||.:....:.|......||.||...........|.
Zfish   141 -GE-QWKTMTYSEYYKSCRTAA---KSFLKLGLERYHGVGILGFNSTEWFIADIAAILAGGFAVG 200

  Fly   201 VYATLGDDGVAHCITETEVT-TVITSHDLLPKFKTLLDKCPLVKTIIYIEDQLQKTETTGFKEGV 264
            :|.|...:...:.....:.. .|:.:|..|.|...:.||.|.:|.||..:|:|::.:.
Zfish   201 IYTTNSPEACQYVAENCQANILVVENHKQLQKILQIQDKLPHLKAIIQYKDELKEKKP------- 258

  Fly   265 KILPFNQVVKTGQDSKFEHVPPKGDDI---------AIIMYTSGSTGTPKGVLLSHKNCIATMKG 320
            .:..:.:.::.|:|.....:    |||         ..::||||:||.||||:|||.|...|...
Zfish   259 NLYTWAEFMELGRDEPDTQL----DDIISSQKPNQCCTLIYTSGTTGQPKGVMLSHDNLTWTAVA 319

  Fly   321 FVDMVPIYPDD----VLIGFLPLAHVFELVAESVCLMTGVPIGYSTPLTLIDTSSKIKRGCKGDA 381
            ....|.:...|    |::.:|||:|:   .|:.:.:...:..|   .:|.......:|.......
Zfish   320 TSQHVSLNDADKLQEVVVSYLPLSHI---AAQMIDIWLPMKAG---GVTYFAQPDALKGSLANTL 378

  Fly   382 TVLKPTCMTSVPLILDRISK-----------------------GINDKVNS---GSAFKKSLFKF 420
            ..::||....||.:.:::.:                       |:...:|.   ||..:|.|
Zfish   379 REIRPTAFLGVPRVWEKMQEKMKSIGAKSSTVRRKVASWAKDVGLQTNLNKMELGSNSRKPL--- 440

  Fly   421 LYQYKVKWVQRGYKTPLIDKLVFKKVAKLMG-GKVRIIMSGGAPLSADTHEQIKTCLCLELIQGY 484
                       .|:  |...|||:||.|.:| .:.....:|.||::.||.|...: |.:.|.:.|
Zfish   441 -----------NYR--LAKHLVFRKVRKALGLDRCTRCYTGAAPITKDTLEFFLS-LDIPLFELY 491

  Fly   485 GLTETTSGATVMDYRDMTYGRTGGPLTVCDIRLVNWEEGNYRVTNKPYPQGEVLIGGECVSQGYY 549
            |::|::...|:...........|..:..|..:|.|.::..         .||:...|..|..||.
Zfish   492 GMSESSGPHTITQANAFRLTSCGKVIPGCKTKLSNPDDEK---------NGEICFWGRHVFMGYL 547

  Fly   550 KLPGKTNEDFFEEDGQRWFKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLGKVESELK-TCG 613
            .:|.||.|..   |.:.|..:||:|::..:..|.|..|.|:|:....||.:....:|..:| ...
Zfish   548 NMPDKTEEAL---DAEGWLHSGDLGKLDENNFLFITGRIKELIITAGGENIPPVPIEDAVKEAIP 609

  Fly   614 IIENICVYGDPTKQYTVALVVPNQNHLE-------------ELAQKHGLGDKSFEELCS--SPII 663
            :|.|..:.||..|..::.|.|..|.:.|             |..:|.|.......|:..  ...:
Zfish   610 LISNAMLIGDKRKFLSMLLTVKCQINGETGVPEDELTPEAVEFCRKLGSSCTRVTEIAGGRDRAV 674

  Fly   664 EKAI---LKEIAEHA--RKCKLQKYEVPAAITLCKEVWSPDMGLVTAAFKLKRKDIQDRYQHDIN 723
            :.||   :..:.|.|  ...::||:      |:..:.:|...|.:....||||..:...|:..|.
Zfish   675 QAAIQDGINRVNEKATSNAQRIQKW------TVLDQDFSIPGGELGPTMKLKRPVVMKMYKEQIE 733

  Fly   724 RMY 726
            ..|
Zfish   734 SFY 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	156/704 (22%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	150/650 (23%)
acsbg2	NP_001119851.1	FAA1	118..738	CDD:223953	156/695 (22%)
acsbg2	NP_001119851.1	ACSBG_like	139..736	CDD:213299	150/672 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900