DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and Acsbg2

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_001034203.1	Gene:	Acsbg2 / 328845	MGIID:	3587728	Length:	667	Species:	Mus musculus

Alignment Length:	697	Identity:	172/697 - (24%)
Similarity:	279/697 - (40%)	Gaps:	144/697 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 TLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKKYNLGDYKWKTFT-----EAERTAAN 158
            |:.::|...|:.:::...|.::           ||:          ||.|.|     |..|.||
Mouse    48 TIPELFQESAERFSAYPALASK-----------NGK----------KWDTLTFSQYYEMCRKAA- 90

  Fly   159 FGRGLRELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIVTVYATLGDDGVAHCITETEVTTVI 223
              :.|.:||.:..:.:.|......||::.|.|........|.:|||...:...:.|.:..|:.:|
Mouse    91 --KSLIKLGLQRFQCVGILGFNSVEWVVTALGTILAGGLCVGIYATNSAEACQYVIQQANVSILI 153

  Fly   224 TSHD-------LLPKFKTLLDKCPLVKTIIYIEDQLQKTETTGFKEGVKILPFNQVVKTGQDSKF 281
            ..:|       |:|.     ||...||.|:..:..|.::.       ..:..:|..::.|.|
Mouse   154 VENDQQLQKILLIPP-----DKMETVKAIVQYKLPLMESM-------ANLYSWNDFMELGND--- 203

  Fly   282 EHVP----------PKGDDIAIIMYTSGSTGTPKGVLLSHKNCIATMKGFVDMVPIY----PDDV 332
              :|          .|.:..|:|:||||:|||||||||||.|...|.......:.|.    ..:.
Mouse   204 --IPNIQLDRVILSQKANQCAVILYTSGTTGTPKGVLLSHDNITWTAGAMSQEMEINRVSGKQNT 266

  Fly   333 LIGFLPLAHVFELVAESVCLMTGVPIGYSTPL--------TLIDTSSKIKRGCKGDATVLKPTCM 389
            ::.:|||:|:   .|:...:...:.||..|..        ||:.|..::           |||..
Mouse   267 IVSYLPLSHI---AAQLTDIWIPIKIGALTFFAQPDALRGTLVYTLQEV-----------KPTLF 317

  Fly   390 TSVPLILDRISKGINDKVNSGSAFKKSLFKFLYQYKVKW----------VQRGYKTPLIDKLVFK 444
            ..||.|.:::...|.:.|...|..:|..|.:.....:|.          :...|:  :...|||.
Mouse   318 MGVPRIWEKMQDTIKENVARSSRLRKKAFAWAKMLGLKVNTKRMLGKRDIPMNYR--MAKALVFA 380

  Fly   445 KVAKLMG-GKVRIIMSGGAPLSADTHEQIKTCLCLELIQG--YGLTETTSGATVMD---YRDMTY 503
            ||...:| .......|..:|||.|..|..   |.|::..|  ||::|.:...||.:   ||.::.
Mouse   381 KVRTSLGLDNCHAFFSSASPLSQDVSEFF---LSLDIPIGEIYGMSECSGPHTVSNKSVYRVLSC 442

  Fly   504 GRTGGPLTVCDIRLVNW-EEGNYRVTNKPYPQGEVLIGGECVSQGYYKLPGKTNEDFFEEDGQRW 567
            |:.   |:.|...|.|. :||          .|||.:.|..|..||......|.| ..:|:|  |
Mouse   443 GKV---LSGCKNMLYNQNKEG----------VGEVCMWGRHVFMGYLNKEEATLE-ALDENG--W 491

  Fly   568 FKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLGKVESELK-TCGIIENICVYGDPTKQYTVA 631
            ..:||||.:.:...|.|..|.|:::....||.||...:|:.:| ...||.:..:.||..|...:.
Mouse   492 LHSGDIGRLDSHDFLYITGRIKEILITAGGENVSPIPIETLVKEKIPIISHAMLVGDKAKFLCML 556

  Fly   632 LVVPNQNHLE--ELAQKHGLGDKSFEELCSS-------------PIIEKAILKEIAEHARKCKLQ 681
            |.:..:...:  |...|..:..|||.::..|             .::..||...|....::....
Mouse   557 LTLKCETDRKSGEPLNKLSVEAKSFCQMLGSQATTVSDILKSRDQVVYTAIQYGIDIVNQQAMSD 621

  Fly   682 KYEVPAAITLCKEVWSPDMGLVTAAFKLKRKDIQDRYQHDINRMYAS 728
            .:.:...|.|.|: :|...|.:....||||..|..:|:..|:.||.|
Mouse   622 SHRIRKWIILEKD-FSIQGGELGPTSKLKRSVITQKYKAQIDSMYLS 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	170/694 (24%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	163/650 (25%)
Acsbg2	NP_001034203.1	ACSBG_like	69..665	CDD:341256	165/672 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900