DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and Acsbg2

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_006244373.1	Gene:	Acsbg2 / 301120	RGDID:	1588580	Length:	698	Species:	Rattus norvegicus

Alignment Length:	756	Identity:	188/756 - (24%)
Similarity:	303/756 - (40%)	Gaps:	147/756 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 APDDIEAKIVRNDDNELTYRTTDPPRDVHVKMLQE--------NIDTLEKVFNYVAKTYTSKRCL 117
            :|......:|:.:...:| .|:..|..|...|.||        .:||..     .|....|..|.
  Rat     2 SPSVTPGHLVKGNSCTVT-NTSCEPAKVGPPMTQEKKAEDPDRGMDTTS-----AAPRLWSTHCD 60

  Fly   118 G--------------TRQILSE--EDEVQQNGRVFKKYNLGDYKWKTFTEAE-----RTAANFGR 161
            |              |...:.|  ::.|::.|......:....||.|.|.::     |.||   |
  Rat    61 GEVLLRLSKHGPGHETPMTIPELFQESVERFGAYPALASKNGKKWDTLTFSQYYDVCRKAA---R 122

  Fly   162 GLRELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIVTVYATLGDDGVAHCITETEVTTVITSH 226
            .|.:||.:....:.|......||::||.|........|.:|||...:...:.|.:..|..:|..:
  Rat   123 SLIKLGLQRFHGVGILGFNSVEWVVAALGAILAGGLCVGIYATNSAEACQYVIKQANVNVLIVEN 187

  Fly   227 D-LLPKFKTL-LDKCPLVKTIIYIEDQLQKTETT-----GFKEGVKILP---FNQVVKTGQDSKF 281
            | .|.|..:: .||...||.|:.....|.:..|.     .|.|....:|   .::|:
  Rat   188 DQQLQKILSIPPDKMETVKAIVQYRLPLMENSTNLYSWQDFMELGNAIPNIQLDRVI-------- 244

  Fly   282 EHVPPKGDDIAIIMYTSGSTGTPKGVLLSHKNCIAT---MKGFVDMVPIY-PDDVLIGFLPLAHV 342
              :..|.:..|:|:||||:||:||||:|||.|...|   |...::::.:. ..|.::.:|||:|:
  Rat   245 --LSQKANQCAVIIYTSGTTGSPKGVMLSHDNITWTAGAMAREIELIHVSGKQDTIVSYLPLSHI 307

  Fly   343 -FELVAESVCLMTGVPIGYSTP----LTLIDTSSKIKRGCKGDATVLKPTCMTSVPLILDRISKG 402
             .:|:...:.:..||...::.|    .||:.|..::           |||....||.:.:::...
  Rat   308 AAQLMDIWIPIKVGVLTFFAQPDALRGTLVYTLQEV-----------KPTYFLGVPRVWEKMQDT 361

  Fly   403 INDKVNSGSAFKKSLFKFLYQYKVKW----------VQRGYKTPLIDKLVFKKVAKLMG-GKVRI 456
            |.:.|...|..:|..|.:.....:|.          :...|:  :...|||.||...:| .....
  Rat   362 IKENVAKSSNLRKKAFAWAKMLGLKVNTKKMLGKRDIPMNYR--MAKALVFTKVRTSLGLDNCHT 424

  Fly   457 IMSGGAPLSADTHEQIKTCLCLELIQG--YGLTETTSGATV---MDYRDMTYGRTGGPLTVCDIR 516
            ..||.:|||.|..|..   |.|::..|  ||:||.:...||   ..||.::.|:.   |..|
  Rat   425 FFSGASPLSQDVSEFF---LSLDIPIGEIYGMTECSGPHTVSCKSIYRVLSCGKV---LNGC--- 480

  Fly   517 LVNWEEGNYRVTNKPYPQ-----GEVLIGGECVSQGYYKLPGKTNE--DFFEEDGQRWFKTGDIG 574
                       .|..|.|     |||.:.|..|..||.   ||.:.  :..:|||  |..:||||
  Rat   481 -----------KNMLYKQNKDGVGEVCMWGRHVFMGYL---GKEDATLEVLDEDG--WLHSGDIG 529

  Fly   575 EIQADGVLKIIDRKKDLVKLQAGEYVSLGKVESELK-TCGIIENICVYGDPTKQYTVALVV---P 635
            .:.:...|.|..|.|:::....||.:....:|:.:| ...||.:..:.||..|..::.|.:   .
  Rat   530 RLDSHDFLYITGRIKEVLITAGGENIWPIPIETLVKEKIPIISHAMLVGDKAKFLSMLLTLKCET 594

  Fly   636 NQNHLEELAQKHGLGDKSFEELCSS-------------PIIEKAILKEIAEHARKCKLQKYEVPA 687
            :|...|.| .|..|...||.::..|             |::..||...|....::.....:.:..
  Rat   595 DQMSGEPL-DKLNLEAISFCQMLGSQAVTVSDILKIRDPVVYTAIQYGIDIVNQQAVSDSHRIRK 658

  Fly   688 AITLCKEVWSPDMGLVTAAFKLKRKDIQDRYQHDINRMYAS 728
            .|.|.|: :|...|.:....||||..|..:|:..|:.||:|
  Rat   659 WIILEKD-FSIQGGELGPTSKLKRDLITQKYKAQIDNMYSS 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	178/719 (25%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	166/647 (26%)
Acsbg2	XP_006244373.1	FAA1	78..698	CDD:223953	171/672 (25%)
Acsbg2	XP_006244373.1	AFD_class_I	100..696	CDD:302604	166/648 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810