Protein Alignment Acsl and ACSL6

DIOPT Version :10

• Sequence 1: NP_001260810.1
• Gene: Acsl / 46068
• FlyBaseID: FBgn0263120
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: NP_056071.2
• Gene: ACSL6 / 23305
• HGNCID: 16496
• Length: 722
• Species: Homo sapiens
• Alignment Length: 644
• Identity: 203/644 - (31%)
• Similarity: 321/644 - (49%)
• Gaps: 55/644 - (8%)

  Fly    99 TLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKKYNLGDYKWKTFTEAERTAANFGRGL 163
            |:.:||........:..|||.|:...                  .|:|.::.|....|...|.||
Human   116 TMYQVFRRGLSISGNGPCLGFRKPKQ------------------PYQWLSYQEVADRAEFLGSGL 162

  Fly   164 RELGQK--PRENIVIFAETRAEWMIAAHGCFKQAMPIVTVYATLGDDGVAHCITETEVTTVITSH 226
            .:...|  ..:.|.:||:.|.||:|....|:..:|.:|.:|.|||...:.:.|...:::|||.
Human   163 LQHNCKACTDQFIGVFAQNRPEWIIVELACYTYSMVVVPLYDTLGPGAIRYIINTADISTVIV-- 225

  Fly   227 DLLPKFKTLLD-----KCPLVKTIIYIEDQLQKTETTGFKEGVKILPFNQVVKTGQDSKFEHVPP 286
            |...|...||:     :.|.:|.||.::...:..:..|.|.||.|.....|...||::....|||
Human   226 DKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQKCGVVIKSMQAVEDCGQENHQAPVPP 290

  Fly   287 KGDDIAIIMYTSGSTGTPKGVLLSHKNCIATMKGFVDM-----VPIYPDDVLIGFLPLAHVFELV 346
            :.||::|:.:|||:||.|||.:|:|.|.:|...||:.:     .|... ||.|.:|||||:||.:
Human   291 QPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTESQWAPTCA-DVHISYLPLAHMFERM 354

  Fly   347 AESVCLMTGVPIG-YSTPLTLIDTSSKIKRGCKGDATVLKPTCMTSVPLILDRISKGINDKVNSG 410
            .:||....|..:| :...:.|:          ..|...|.||....||.:|:|:...|..:.|
Human   355 VQSVVYCHGGRVGFFQGDIRLL----------SDDMKALCPTIFPVVPRLLNRMYDKIFSQAN-- 407

  Fly   411 SAFKKSLFKFLYQYKVKWVQRGY--KTPLIDKLVFKKVAKLMGGKVRIIMSGGAPLSADTHEQIK 473
            :..|:.|.:|..:.|...|:.|.  ...:.|:|.|.|:...:||.||:|::|.||.|......::
Human   408 TPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLR 472

  Fly   474 TCLCLELIQGYGLTETTSGATVMDYRDMTYGRTGGPLTVCDIRLVNWEEGNYRVTNKPYPQGEVL 538
            ..|..::.:|||.||.|:|.|.....|.|.|..|.||....|:||:.||.||....   .:||:.
Human   473 AALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACK---GEGEIC 534

  Fly   539 IGGECVSQGYYKLPGKTNEDFFEEDGQRWFKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLG 603
            :.|..|.:||.|.|.:|.| ..:.||  |..|||||:....|.||||||||.:.||..||||:..
Human   535 VRGPNVFKGYLKDPDRTKE-ALDSDG--WLHTGDIGKWLPAGTLKIIDRKKHIFKLAQGEYVAPE 596

  Fly   604 KVESELKTCGIIENICVYGDPTKQYTVALVVPNQNHLEELAQKHGLGDKSFEELCSSPIIEKAIL 668
            |:|:.......:..|.|:||..|.:.|.:|||:...:...|||.|: :.::.:||::..::||||
Human   597 KIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGI-EGTYADLCTNKDLKKAIL 660

  Fly   669 KEIAEHARKCKLQKYEVPAAITLCKEVWSPDMGLVTAAFKLKRKDIQDRYQHDINRMYA 727
            :::....::..|..:|...||.:..:::|...||:|...|.||.::::.::..|..:|:
Human   661 EDMVRLGKESGLHSFEQVKAIHIHSDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYS 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	LC_FACS_euk1	142..714	CDD:341294	194/586 (33%)
ACSL6	NP_056071.2	LC-FACS_euk	141..719	CDD:341250	195/617 (32%)