DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and ACSBG1

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_016877514.1	Gene:	ACSBG1 / 23205	HGNCID:	29567	Length:	748	Species:	Homo sapiens

Alignment Length:	778	Identity:	191/778 - (24%)
Similarity:	311/778 - (39%)	Gaps:	170/778 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QKPWKRRQD------------SRRVKAKPINQKML-----------VDESKY-APDDIEAKIVRN 72
            :.|.:.|||            |.....:|::::.|           |:.::: ||:  ||.....
Human    23 ETPQESRQDMIVRTTQEKLKTSSLTDRQPLSKESLNHALELSVPEKVNNAQWDAPE--EALWTTR 85

  Fly    73 DDNELTYRTTDP-----PRDVHVKMLQENIDTLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQN 132
            .|..:..| .||     |..|| :|..|.:|           .|.....||
Human    86 ADGRVRLR-IDPSCPQLPYTVH-RMFYEALD-----------KYGDLIALG-------------- 123

  Fly   133 GRVFKKYNLGDYKWK--TFTEAERTAANFGRGLRELGQKPRENIVIFAETRAEWMIAAHGCFKQA 195
               ||:.:    ||:  ::::....|....:|..:||.|...::.|......||..:|.|.....
Human   124 ---FKRQD----KWEHISYSQYYLLARRAAKGFLKLGLKQAHSVAILGFNSPEWFFSAVGTVFAG 181

  Fly   196 MPIVTVYAT--------LGDDGVAHCI---TETEVTTVITSHDLLPKFKTLLDKCPLVKTIIYIE 249
            ..:..:|.|        :..|..|:.|   |:.::..::.....||..|.:         :||.|
Human   182 GIVTGIYTTSSPEACQYIAYDCCANVIMVDTQKQLEKILKIWKQLPHLKAV---------VIYKE 237

  Fly   250 DQLQKTETTGFKEGVKILPFNQVVKTGQDSKFEHVPPKGDDIAIIMYTSGSTGTPKGVLLSHKNC 314
            ....|.......|....|. |:|.:...|:..:...|  :...:::||||:||.||||:||..|.
Human   238 PPPNKMANVYTMEEFMELG-NEVPEEALDAIIDTQQP--NQCCVLVYTSGTTGNPKGVMLSQDNI 299

  Fly   315 IATMKGFVDMVPIYP----DDVLIGFLPLAHVFELVAESVCLMTGVPIG----YSTP----LTLI 367
            ..|.:.......|.|    .:|::.:|||:|:   .|:...|.||:..|    ::.|    .:|:
Human   300 TWTARYGSQAGDIRPAEVQQEVVVSYLPLSHI---AAQIYDLWTGIQWGAQVCFAEPDALKGSLV 361

  Fly   368 DTSSKIKRGCKGDATVLKPTCMTSVPLILDRISKGIND-KVNSGSAFKKSLFKFLYQYKVKWVQ- 430
            :|..::           :||....||.:.::|.:.|.: ...||...:|.|   |:...|...|
Human   362 NTLREV-----------EPTSHMGVPRVWEKIMERIQEVAAQSGFIRRKML---LWAMSVTLEQN 412

  Fly   431 --------RGYKTPLIDKLVFKKVAKLMG-GKVRIIMSGGAPLSADTHEQIKTCLCLELIQGYGL 486
                    :.:.|.|.|.||..||.:.:| .|.:....|.||:.|:| :.....|.:.|..||||
Human   413 LTCPGSDLKPFTTRLADYLVLAKVRQALGFAKCQKNFYGAAPMMAET-QHFFLGLNIRLYAGYGL 476

  Fly   487 TETTSGATVM----DYRDMTYGRTGGPLTVCDIRLVNWE-EGNYRVTNKPYPQGEVLIGGECVSQ 546
            :| |||...|    :||..:.|:.   :..|.::|||.: ||          .||:.:.|..:..
Human   477 SE-TSGPHFMSSPYNYRLYSSGKL---VPGCRVKLVNQDAEG----------IGEICLWGRTIFM 527

  Fly   547 GYYKLPGKTNEDFFEEDGQRWFKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLGKVESELK- 610
            ||..:..||.|...||.   |..|||.|.:.|||.|.|..|.|:|:....||.|....:|..:|
Human   528 GYLNMEDKTCEAIDEEG---WLHTGDAGRLDADGFLYITGRLKELIITAGGENVPPVPIEEAVKM 589

  Fly   611 TCGIIENICVYGDPTKQYTVALVVPNQNHLEELAQKHGLGDKSFEELCS---------SPIIEK- 665
            ...||.|..:.||..|..::.|.:......:...|...|.:::. |.|.         |.||||
Human   590 ELPIISNAMLIGDQRKFLSMLLTLKCTLDPDTSDQTDNLTEQAM-EFCQRVGSRATTVSEIIEKK 653

  Fly   666 --AILKEIAEHARKCKLQKYEVPAAI---TLCKEVWSPDMGLVTAAFKLKRKDIQDRYQHDIN 723
              |:.:.|.|..|:..:.....|..|   .:.:..:|...|.:....||||..:.::|:..::
Human   654 DEAVYQAIEEGIRRVNMNAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKDGVS 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	171/686 (25%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	164/639 (26%)
ACSBG1	XP_016877514.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810