DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and ACSL4

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_024308119.1	Gene:	ACSL4 / 2182	HGNCID:	3571	Length:	717	Species:	Homo sapiens

Alignment Length:	699	Identity:	336/699 - (48%)
Similarity:	449/699 - (64%)	Gaps:	34/699 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 WKRRQDSRRVKAKPINQKMLVDESKYAPDDIEAKIVRNDDNELTYRTTDPPRDVHVKMLQENIDT 99
            ||:...::|:||||.:.|         |......:...|    :....|.|          ..||
Human    43 WKKNAMAKRIKAKPTSDK---------PGSPYRSVTHFD----SLAVIDIP----------GADT 84

  Fly   100 LEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKKYNLGDYKWKTFTEAERTAANFGRGLR 164
            |:|:|::....:..|..||||:|||||:|:|.||:||||..||:|||..:.|..|...|||.||.
Human    85 LDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNNFGSGLT 149

  Fly   165 ELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIVTVYATLGDDGVAHCITETEVTTVITSHDLL 229
            .||.||:..|.||.||||||||||..|||...|:||:|||||.:.|.|.:.|:|.:.:|||.:||
Human   150 ALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVELL 214

  Fly   230 -PKFKTLLDKCPLVKTIIYIEDQ-LQKTETTGFKEGVKILPFNQVVKTGQDSKFEHVPPK---GD 289
             .|.||.|.....||.|||:::: :.|.|   :.||.:|.....|.:.|.:.:...:||.   ..
Human   215 ESKLKTALLDISCVKHIIYVDNKAINKAE---YPEGFEIHSMQSVEELGSNPENLGIPPSRPTPS 276

  Fly   290 DIAIIMYTSGSTGTPKGVLLSHKNCIATMKGFVDMVP-IYPDDVLIGFLPLAHVFELVAESVCLM 353
            |:||:||||||||.||||::.|.|.||.|.|..:.:| :.|.|..||:||||||.||.||..|..
Human   277 DMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFT 341

  Fly   354 TGVPIGYSTPLTLIDTSSKIKRGCKGDATVLKPTCMTSVPLILDRISKGINDKVNSGSAFKKSLF 418
            .|..||||:||||.|.|||||:|.|||.||||||.|.:||.|:|||.|.:..||...:..:|:||
Human   342 YGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLF 406

  Fly   419 KFLYQYKVKWVQRGYKTPLIDKLVFKKVAKLMGGKVRIIMSGGAPLSADTHEQIKTCLCLELIQG 483
            |..|.||::.:::||..||.:.|:||||..|:||.||:::|||||||..||..:..|.|..:.||
Human   407 KIGYDYKLEQIKKGYDAPLCNLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQG 471

  Fly   484 YGLTETTSGATVMDYRDMTYGRTGGPLTVCDIRLVNWEEGNYRVTNKPYPQGEVLIGGECVSQGY 548
            |||||:....||.:..|.|.||.|.||..|:|:|.:|:||.|.:.:||.|:||::|||:.:|.||
Human   472 YGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGY 536

  Fly   549 YKLPGKTNEDF-FEEDGQRWFKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLGKVESELKTC 612
            :|...||.||: .:|:|||||.||||||...||.|:|||||||||||||||||||||||:.||.|
Human   537 FKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNC 601

  Fly   613 GIIENICVYGDPTKQYTVALVVPNQNHLEELAQKHGLGDKSFEELCSSPIIEKAILKEIAEHARK 677
            .:|:|||.:....:.|.::.|||||..|..|||:.|: :.::.::|::|.:|..|||||.|.|..
Human   602 PLIDNICAFAKSDQSYVISFVVPNQKRLTLLAQQKGV-EGTWVDICNNPAMEAEILKEIREAANA 665

  Fly   678 CKLQKYEVPAAITLCKEVWSPDMGLVTAAFKLKRKDIQDRYQHDINRMY 726
            .||:::|:|..:.|..|.|:|:.||||.|||||||::::.|..||.|||
Human   666 MKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMY 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	324/639 (51%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	298/590 (51%)
ACSL4	XP_024308119.1	LC-FACS_euk	127..714	CDD:213293	298/590 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	454	1.000	Domainoid score	I505
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I796
Isobase	1	0.950	-	0	Normalized mean entropy	S1350
OMA	1	1.010	-	-		QHG53493
OrthoDB	1	1.010	-	-		D141523at33208
OrthoFinder	1	1.000	-	-		FOG0001203
OrthoInspector	1	1.000	-	-		otm40319
orthoMCL	1	0.900	-	-		OOG6_100746
Panther	1	1.100	-	-	LDO	PTHR43272
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R654
SonicParanoid	1	1.000	-	-		X593
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820