DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and acs-5

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_499799.1	Gene:	acs-5 / 176785	WormBaseID:	WBGene00013575	Length:	687	Species:	Caenorhabditis elegans

Alignment Length:	687	Identity:	203/687 - (29%)
Similarity:	339/687 - (49%)	Gaps:	66/687 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 ESKYAPDDIEAKIVRNDDNELTYRTTDPPRDVHVKMLQENIDTLEKVFNYVAKTYTSKR---CLG 118
            |.|..|...::.::.|:..::..|            ....:.||..||   .|..|...   |:|
Worm    44 EVKGQPGVWKSALMENESEDVLTR------------FYPEVATLHDVF---VKGKTESNGGPCVG 93

  Fly   119 TRQILSEEDEVQQNGRVFKKYNLGDYKWKTFTEAERTAANFGRGL-RELGQKPRE--NIVIFAET 180
            ||   |..|              .||::.|:.:....|.|....| .|.|..|..  ||.|:|..
Worm    94 TR---SSGD--------------ADYEFLTYDDVHEQAKNLSMTLVHEFGLTPANTTNIGIYARN 141

  Fly   181 RAEWMIAAHGCFKQAMPIVTVYATLGDDGVAHCITETEVTTVITSHDLLPKFKTLL---DKCPLV 242
            ..:|:::|..|.:|:|.:|.:|.|||.:.....|::.|::.||.  |...|.::|:   :..|.:
Worm   142 SPQWLVSAVACVEQSMVVVPLYDTLGAEAATFIISQAEISVVIV--DSFKKAESLIKNRENMPTL 204

  Fly   243 KTIIYIEDQLQKTETTGFKEGVKILPFNQVVKTGQDSKFEHVPPKGDDIAIIMYTSGSTGTPKGV 307
            |.||.|:...:..:.|...:.:::......:..|....|.:..||.||..||.||||:|||||||
Worm   205 KNIIVIDSADELKDGTAIIDTIRVESLTNALNLGSRYPFTNNLPKPDDNYIICYTSGTTGTPKGV 269

  Fly   308 LLSHKNCIATMKGFVDMVPIYPDDVL------IGFLPLAHVFELVAESVCLMTGVPIGYSTPLTL 366
            :|:|.|.:|.:.||:.::..:...::      |.:|||:|:.|.:.....|..|..|||.....
Worm   270 MLTHSNIVANISGFLKILFAFQPSMIDATQVHISYLPLSHMMEQLTHWTLLGFGSKIGYFRGSI- 333

  Fly   367 IDTSSKIKRGCKGDATVLKPTCMTSVPLILDRISKGINDKVNSGSAFKKSLFKFLYQYKVKWVQR 431
                    :|...|...||||....||.:|:|:...|..||.......|.::.|.:..|:..|:.
Worm   334 --------QGLTDDIKTLKPTVFPVVPRLLNRLYDAITSKVQQQGFMAKLVYNFAFARKLSLVKA 390

  Fly   432 GY--KTPLIDKLVFKKVAKLMGGKVRIIMSGGAPLSADTHEQIKTCLCLELIQGYGLTETTSGAT 494
            |.  :..:.|:|||.|:.:.:||||.::::|.||:|:...|..:..|...:::|||.||.|:.||
Worm   391 GKVGRDTIWDRLVFNKIQQQIGGKVDLMVTGSAPISSTVLETCRVTLGTTIVEGYGQTECTALAT 455

  Fly   495 VMDYRDMTYGRTGGPLTVCDIRLVNWEEGNYRVTNKPYPQGEVLIGGECVSQGYYKLPGKTNEDF 559
            .....|.:.|..|.|.....::|.:..:.||...:   .:||:.|.|.||::||||.|.:|.| .
Worm   456 FTWMGDPSTGHCGAPAPCALVKLGDVPDLNYFAKD---GKGEIRIKGPCVTKGYYKDPERTAE-L 516

  Fly   560 FEEDGQRWFKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLGKVESELKTCGIIENICVYGDP 624
            |:|:|  :.:||||||:..:|.::||||||.:.||..||||:..|:|.......:::.:.|.||.
Worm   517 FDEEG--FLQTGDIGEMLPNGTIRIIDRKKHIFKLAQGEYVAPEKIEQVYIRTPVVQQVYVDGDS 579

  Fly   625 TKQYTVALVVPNQNHLEELAQKHGLGDKSFEELCSSPIIEKAILKEIAEHARKCKLQKYEVPAAI 689
            .:::.:|:|||..:.|:|...|.|.|.:..||:|:....::.:|.|:....:..||...|....:
Worm   580 LERWLIAVVVPEPDVLKEWNDKQGSGSRKIEEICNDEKAKEFVLSELHAIGKANKLNSIEQVKKV 644

  Fly   690 TLCKEVWSPDMGLVTAAFKLKRKDIQDRYQHDINRMY 726
            .|..:.::.:.||:|...|.||..::.:|:..:.::|
Worm   645 ILTSDTFTVENGLLTPTLKAKRPQLRLKYKDGMAKVY 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	198/649 (31%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	185/597 (31%)
acs-5	NP_499799.1	PLN02736	65..685	CDD:178337	199/666 (30%)
acs-5	NP_499799.1	LC-FACS_euk	101..681	CDD:213293	185/596 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53493
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820