DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and Acsbg1

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_599216.1	Gene:	Acsbg1 / 171410	RGDID:	708557	Length:	721	Species:	Rattus norvegicus

Alignment Length:	758	Identity:	176/758 - (23%)
Similarity:	293/758 - (38%)	Gaps:	186/758 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 WKRRQDSR-RVKAKPINQKMLVDESKYAPDDIEAKIVRNDDNELTYRTTDPPRDVHVKMLQENID 98
            |..|.|.| |::.:|.                               .|..|..|| :|..|.:|
  Rat    79 WTTRADGRVRLRLEPF-------------------------------CTQLPYTVH-QMFYEALD 111

  Fly    99 TLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKKYNLGDYKWK--TFTEAERTAANFGR 161
                       .|.:...||                 ||:.:    ||:  ::.:....|....:
  Rat   112 -----------KYGNLSALG-----------------FKRKD----KWERISYYQYYLIARKVAK 144

  Fly   162 GLRELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIVTVYATLGDDG---VAH-CITETEVTTV 222
            |..:||.:...::.|......||..:|.|.......:..:|.|...:.   :|| |  ...|..|
  Rat   145 GFLKLGLERAHSVAILGFNSPEWFFSAVGTVFAGGIVTGIYTTSSPEACQYIAHDC--RANVIVV 207

  Fly   223 ITSHDLLPKFKTLLDKCPLVKTIIYIEDQLQKTETTGFKEGVKILPFNQVVKTGQDSKFEHVPPK 287
            .|...|....|...|...|...:||.|...:|.        ..:....::::.||:     ||.:
  Rat   208 DTQKQLEKILKIWKDLPHLKAVVIYQEPPPKKM--------ANVYTMEELIELGQE-----VPEE 259

  Fly   288 GDD----------IAIIMYTSGSTGTPKGVLLSHKNCIATMKGFVDMVPIYP----DDVLIGFLP 338
            ..|          ..:::||||:||.||||:||..|...|.:.......|.|    .:|::.:||
  Rat   260 ALDAIIDTQQPNQCCVLVYTSGTTGNPKGVMLSQDNITWTARYGSQAGDIQPAEVQQEVVVSYLP 324

  Fly   339 LAHVFELVAESVCLMTGVPIG----YSTP----LTLIDTSSKIKRGCKGDATVLKPTCMTSVPLI 395
            |:|:   .|:...|.||:..|    ::.|    .||::|..::           :||....||.:
  Rat   325 LSHI---AAQIYDLWTGIQWGAQVCFADPDALKGTLVNTLREV-----------EPTSHMGVPRV 375

  Fly   396 LDRISKGIND-KVNSGSAFKKSLFKFLYQYKVKWVQ---------RGYKTPLIDKLVFKKVAKLM 450
            .::|.:.|.: ...||...:|.|   |:...|...|         :.:.:.|.|.||..:|.:.:
  Rat   376 WEKIMERIQEVAAQSGFIRRKML---LWAMSVTLEQNLTCPSNDLKPFTSRLADYLVLARVRQAL 437

  Fly   451 G-GKVRIIMSGGAPLSADTHEQIKTCLCLELIQGYGLTETTSG---ATVMDYRDMTYGRTGGPLT 511
            | .|.:....|.||::|:| ::....|.:.|..||||:|:|..   ::..:||..:.||.   :.
  Rat   438 GFAKCQKNFYGAAPMTAET-QRFFLGLNIRLYAGYGLSESTGPHFMSSPYNYRLYSSGRV---VP 498

  Fly   512 VCDIRLVNWEEGNYRVTNKPYPQGEVLIGGECVSQGYYKLPGKTNEDFFEEDGQRWFKTGDIGEI 576
            .|.::|||.:....         ||:.:.|..:..||..:..||:|..   |.:.|..|||:|.:
  Rat   499 GCRVKLVNQDADGI---------GEICLWGRTIFMGYLNMEDKTHEAI---DSEGWLHTGDMGRL 551

  Fly   577 QADGVLKIIDRKKDLVKLQAGEYVSLGKVESELK-TCGIIENICVYGDPTKQYTVALVV------ 634
            ..||.|.|..|.|:|:....||.|....:|..:| ...||.:..:.||..|..::.|.:
  Rat   552 DDDGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISSAMLIGDQRKFLSMLLTLKCTLNP 616

  Fly   635 ----PNQNHLE---ELAQKHGLGDKSFEELCSSPIIEKAILKEIAE---------HARKCKLQKY 683
                |..|..|   |..|:.|....:..|:....  ::|:.:.|.|         .||...:||:
  Rat   617 ETSEPTDNLTEQAVEFCQRVGSKASTVSEIVGQK--DEAVYQAIHEGIQRVNANAAARPYHIQKW 679

  Fly   684 EVPAAITLCKEVWSPDMGLVTAAFKLKRKDIQDRYQHDINRMY 726
                  .:.:..:|...|.:....||||..:.::|:..|:..|
  Rat   680 ------AILERDFSISGGELGPTMKLKRLTVLEKYKDIIDSFY 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	165/697 (24%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	157/648 (24%)
Acsbg1	NP_599216.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
Acsbg1	NP_599216.1	ACSBG_like	122..716	CDD:341256	158/653 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810