DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and Acsl1

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_001289092.1	Gene:	Acsl1 / 14081	MGIID:	102797	Length:	699	Species:	Mus musculus

Alignment Length:	703	Identity:	228/703 - (32%)
Similarity:	353/703 - (50%)	Gaps:	70/703 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RVKA--KPINQKMLVDESKYAPDDIEAKIVRNDDNELTYRTTDPPRDVHVKMLQENIDTLEKVFN 105
            |.||  .|.:..|...|.....|.|....|..||..|.|             ..:::.|:...|.
Mouse    47 RPKALKPPCDLSMQSVEIAGTTDGIRRSAVLEDDKLLVY-------------YYDDVRTMYDGFQ 98

  Fly   106 YVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKKYNLGDYKWKTFTEAERTAANFGRGLRELGQKP 170
            ...:...:..|||:|                 |.| ..|:|.::.|....|...|.||.:.|.||
Mouse    99 RGIQVSNNGPCLGSR-----------------KPN-QPYEWISYKEVAELAECIGSGLIQKGFKP 145

  Fly   171 --RENIVIFAETRAEWMIAAHGCFKQAMPIVTVYATLGDDGVAHCITETEVTTVITSHDLLPKFK 233
              .:.|.:|::.|.||:|...|||..:|.:|.:|.|||.|.:.:.:.:.|::.:..  |...|.|
Mouse   146 CSEQFIGLFSQNRPEWVIVEQGCFSYSMVVVPLYDTLGADAITYIVNKAELSVIFA--DKPEKAK 208

  Fly   234 TLLD-----KCPLVKTIIYIEDQLQKTETTGFKEGVKILPFNQVVKTGQDSKFEHVPPKGDDIAI 293
            .||:     ..|.:|.|:.::.........|.|.||:|:....:...|:.::.:..||:.:|:||
Mouse   209 LLLEGVENKLTPCLKIIVIMDSYGSDLVERGKKCGVEIISLKALEDLGRVNRVKPKPPEPEDLAI 273

  Fly   294 IMYTSGSTGTPKGVLLSHKNCIATMKGFVDMVP----IYPDDVLIGFLPLAHVFELVAESVCLMT 354
            |.:|||:||.|||.:::|:|.|....||:....    ...|||||.||||||:||.|.|.|.|..
Mouse   274 ICFTSGTTGNPKGAMITHQNIINDCSGFIKATESAFIASTDDVLISFLPLAHMFETVVECVMLCH 338

  Fly   355 GVPIGY--STPLTLIDTSSKIKRGCKGDATVLKPTCMTSVPLILDRISKGINDKVNSGSAFKKSL 417
            |..||:  .....|:|           |..||:||....||.:|:|:...|..:.|  ::.|:.|
Mouse   339 GAKIGFFQGDIRLLMD-----------DLKVLQPTIFPVVPRLLNRMFDRIFGQAN--TSLKRWL 390

  Fly   418 FKFLYQYKVKWVQRGY--KTPLIDKLVFKKVAKLMGGKVRIIMSGGAPLSADTHEQIKTCLCLEL 480
            ..|..:.|...::.|.  ...|.|||:|.|:...:|||||::::|.||:||.....::|.|..:.
Mouse   391 LDFASKRKEAELRSGIVRNNSLWDKLIFHKIQSSLGGKVRLMITGAAPVSATVLTFLRTALGCQF 455

  Fly   481 IQGYGLTETTSGATVMDYRDMTYGRTGGPLTVCDIRLVNWEEGNYRVTNKPYPQGEVLIGGECVS 545
            .:|||.||.|:|..:....|.|.|..|.|:....::||:.||.||..:.   .:|||.:.|..|.
Mouse   456 YEGYGQTECTAGCCLSLPGDWTAGHVGAPMPCNYVKLVDVEEMNYLASK---GEGEVCVKGANVF 517

  Fly   546 QGYYKLPGKTNEDFFEEDGQRWFKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLGKVESELK 610
            :||.|.|.:|.| ..::||  |..|||||:...:|.||||||||.:.||..|||::..|:|:...
Mouse   518 KGYLKDPARTAE-ALDKDG--WLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYL 579

  Fly   611 TCGIIENICVYGDPTKQYTVALVVPNQNHLEELAQKHGLGDKSFEELCSSPIIEKAILKEIAEHA 675
            ....:..:.|:|:..:.:.:|:|||:...|...|||.|| ..||||||.:..|.||||.::.:..
Mouse   580 RSEAVAQVFVHGESLQAFLIAVVVPDVESLPSWAQKRGL-QGSFEELCRNKDINKAILDDLLKLG 643

  Fly   676 RKCKLQKYEVPAAITLCKEVWSPDMGLVTAAFKLKRKDIQDRYQHDINRMYAS 728
            ::..|:.:|....|.:..|::|.|.||:|...|.||.::::.::..|:.:||:
Mouse   644 KEAGLKPFEQVKGIAVHPELFSIDNGLLTPTLKAKRPELRNYFRSQIDELYAT 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	213/646 (33%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	205/598 (34%)
Acsl1	NP_001289092.1	LC-FACS_euk	117..695	CDD:341250	205/599 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53493
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820