DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and Acsl4

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_006257376.1	Gene:	Acsl4 / 113976	RGDID:	69401	Length:	711	Species:	Rattus norvegicus

Alignment Length:	729	Identity:	341/729 - (46%)
Similarity:	458/729 - (62%)	Gaps:	48/729 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VYDIITLPVYLVLQ-------KPW-------KRRQDSRRVKAKPINQKMLVDESKYAPDDIEAKI 69
            |..|:.|||:|::.       .||       |:...::|:||||.:.|         |......:
  Rat     7 VLTIVLLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDK---------PGSPYRSV 62

  Fly    70 VRNDDNELTYRTTDPPRDVHVKMLQENIDTLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGR 134
            ...|    :....|.|          ..|||:|:|::....:..|..||||:|||||:|:|.||:
  Rat    63 THFD----SLAVIDIP----------GADTLDKLFDHAVAKFGKKDSLGTREILSEENEMQPNGK 113

  Fly   135 VFKKYNLGDYKWKTFTEAERTAANFGRGLRELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIV 199
            ||||..||:|||..:.|......|||.||..||.||:..|.||.||||||||||..|||...|:|
  Rat   114 VFKKLILGNYKWINYLEVNCRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLV 178

  Fly   200 TVYATLGDDGVAHCITETEVTTVITSHDLL-PKFKTLLDKCPLVKTIIYIEDQ-LQKTETTGFKE 262
            |:|||||.:.|.|.:.|:|.:.:|||.:|| .|.|..|.....||.|||:::: :.:.|   :.|
  Rat   179 TLYATLGKEAVVHGLNESEASYLITSVELLESKLKAALLDINCVKHIIYVDNKTINRAE---YPE 240

  Fly   263 GVKILPFNQVVKTGQDSKFEHVPPK---GDDIAIIMYTSGSTGTPKGVLLSHKNCIATMKGFVDM 324
            |::|.....|.:.|...:...:||.   ..|:||:||||||||.||||::.|.|.||.|.|..:.
  Rat   241 GLEIHSMQSVEELGSKPENSSIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCER 305

  Fly   325 VP-IYPDDVLIGFLPLAHVFELVAESVCLMTGVPIGYSTPLTLIDTSSKIKRGCKGDATVLKPTC 388
            :| :.|.|..||:||||||.||.||..|...|..||||:||||.|.|||||:|.|||.||||||.
  Rat   306 IPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTL 370

  Fly   389 MTSVPLILDRISKGINDKVNSGSAFKKSLFKFLYQYKVKWVQRGYKTPLIDKLVFKKVAKLMGGK 453
            |.:||.|:|||.|.:..||...:..:|:|||..|.||::.:::||..||.:.::||||..|:||.
  Rat   371 MAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLILFKKVKALLGGN 435

  Fly   454 VRIIMSGGAPLSADTHEQIKTCLCLELIQGYGLTETTSGATVMDYRDMTYGRTGGPLTVCDIRLV 518
            ||:::|||||||..||..:..|.|..:.|||||||:....||.:..|.|.||.|.||..|:|:|.
  Rat   436 VRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLK 500

  Fly   519 NWEEGNYRVTNKPYPQGEVLIGGECVSQGYYKLPGKTNEDF-FEEDGQRWFKTGDIGEIQADGVL 582
            :|:||.|.|.:||.|:||::|||:.:|.||:|...||.||: .:|:|||||.||||||...||.|
  Rat   501 DWQEGGYTVHDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCL 565

  Fly   583 KIIDRKKDLVKLQAGEYVSLGKVESELKTCGIIENICVYGDPTKQYTVALVVPNQNHLEELAQKH 647
            :|||||||||||||||||||||||:.||.|.:|:|||.:....:.|.::.|||||..|..|||:.
  Rat   566 QIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKKLTLLAQQK 630

  Fly   648 GLGDKSFEELCSSPIIEKAILKEIAEHARKCKLQKYEVPAAITLCKEVWSPDMGLVTAAFKLKRK 712
            |: :.|:.::|::|.:|..|||||.|.|...||:::|:|..:.|..|.|:|:.||||.|||||||
  Rat   631 GV-EGSWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRK 694

  Fly   713 DIQDRYQHDINRMY 726
            ::::.|..||.|||
  Rat   695 ELKNHYLKDIERMY 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	322/639 (50%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	296/590 (50%)
Acsl4	XP_006257376.1	LC_FACS_euk1	121..696	CDD:341294	292/578 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	454	1.000	Domainoid score	I479
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	639	1.000	Inparanoid score	I788
OMA	1	1.010	-	-		QHG53493
OrthoDB	1	1.010	-	-		D141523at33208
OrthoFinder	1	1.000	-	-		FOG0001203
OrthoInspector	1	1.000	-	-		otm44447
orthoMCL	1	0.900	-	-		OOG6_100746
Panther	1	1.100	-	-	LDO	PTHR43272
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X593
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840