DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and acsl4

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_031747938.1	Gene:	acsl4 / 100494759	XenbaseID:	XB-GENE-5966957	Length:	711	Species:	Xenopus tropicalis

Alignment Length:	731	Identity:	329/731 - (45%)
Similarity:	463/731 - (63%)	Gaps:	52/731 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VYDIITLPVYLVLQK-------PW-------KRRQDSRRVKAKPINQKMLVDESKYAPDDIEAKI 69
            |..::.|||||::..       ||       |:.:.:.|:||||::.|   ..|.|
Frog     7 VCTVLLLPVYLLMFVYSTLTFIPWYFLTNAKKKIEMANRLKAKPVSDK---PGSPY--------- 59

  Fly    70 VRNDDNELTYRTTDPPRDVHVKMLQENIDTLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGR 134
             |...:..|..|.|.|          ..:||:|:|.:....:..:.|||||:|||||:|.|.||:
Frog    60 -RTVSHFETLATIDVP----------GANTLDKLFEHGVAAFGKRDCLGTREILSEENEKQPNGK 113

  Fly   135 VFKKYNLGDYKWKTFTEAERTAANFGRGLRELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIV 199
            ||||..||:|||.::.|......:.|.||..||.||:..|.||.||||||||.|..|||...|:|
Frog   114 VFKKLILGEYKWLSYEEVSLRVHHLGSGLSALGLKPKSTIAIFCETRAEWMITAQACFKYNFPLV 178

  Fly   200 TVYATLGDDGVAHCITETEVTTVITSHDLL-PKFKTLLDKCPLVKTIIYI-EDQLQKTETTGFKE 262
            |:|||||::.||:.:.|:..:.:.||.:|| .|.|::|.:...:|.|||: :..:.|.|   :..
Frog   179 TLYATLGEEAVAYGLNESGASYLFTSAELLETKLKSVLSQVTGLKHIIYVGKKNISKAE---YPA 240

  Fly   263 GVKILPFNQVVKTGQDSKFEHVP-----PKGDDIAIIMYTSGSTGTPKGVLLSHKNCIATMKGFV 322
            .::|.....|.:.|  :|.|::.     |...|:|::||||||||.||||::.|.|.||.|.|..
Frog   241 SLEIHNIEAVEELG--AKQENLSKPTSRPLPSDLAVVMYTSGSTGRPKGVMMIHSNLIAGMAGQC 303

  Fly   323 DMVP-IYPDDVLIGFLPLAHVFELVAESVCLMTGVPIGYSTPLTLIDTSSKIKRGCKGDATVLKP 386
            :.:| :.|.|..||:||||||.|:.||..|:..|..||||:||||.|.|||||:|.|||.|||:|
Frog   304 ERIPGLGPKDTYIGYLPLAHVLEMTAEISCVTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLRP 368

  Fly   387 TCMTSVPLILDRISKGINDKVNSGSAFKKSLFKFLYQYKVKWVQRGYKTPLIDKLVFKKVAKLMG 451
            |.|.:||.|:|||.|.:..||...:.|:::|||..|.||::.:::||..||.:.|:||||..|:|
Frog   369 TLMAAVPEIMDRIYKNVMSKVQEMNVFQRTLFKLGYDYKLEQIKKGYDAPLCNMLLFKKVKALLG 433

  Fly   452 GKVRIIMSGGAPLSADTHEQIKTCLCLELIQGYGLTETTSGATVMDYRDMTYGRTGGPLTVCDIR 516
            |.||:::.||||||..|...:..|.|..:.||||||||....|:.:..|.:.||.|.|||.|:::
Frog   434 GNVRMMLCGGAPLSPQTQRFMNICFCCPVGQGYGLTETCGAGTITEVCDYSTGRVGAPLTCCEMK 498

  Fly   517 LVNWEEGNYRVTNKPYPQGEVLIGGECVSQGYYKLPGKTNEDFF-EEDGQRWFKTGDIGEIQADG 580
            |.:|:||.|...:||:|:||::|||:.||.||:|...|:.|||: :.:|||||.||||||...||
Frog   499 LRDWQEGGYTNLDKPHPRGEIIIGGQNVSMGYFKNEEKSMEDFYVDANGQRWFCTGDIGEFHPDG 563

  Fly   581 VLKIIDRKKDLVKLQAGEYVSLGKVESELKTCGIIENICVYGDPTKQYTVALVVPNQNHLEELAQ 645
            .|:|||||||||||||||||||||||:.||.|.:|:|||.|.:..:.|.::.|||||..|..||:
Frog   564 CLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAYANSFQSYVISFVVPNQKKLTSLAE 628

  Fly   646 KHGLGDKSFEELCSSPIIEKAILKEIAEHARKCKLQKYEVPAAITLCKEVWSPDMGLVTAAFKLK 710
            :.|: |.::|::|::|.:|..:|:||.|.|...||:::|:|..:.|..:.|:|:.||||.|||||
Frog   629 QKGI-DGTWEDICNNPEMETEVLREIKEVASSLKLERFEIPIKVRLSPDPWTPETGLVTDAFKLK 692

  Fly   711 RKDIQDRYQHDINRMY 726
            ||::::.|..||.|||
Frog   693 RKELKNHYITDIERMY 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	307/641 (48%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	282/592 (48%)
acsl4	XP_031747938.1	PRK07868	<48..>160	CDD:236121	50/134 (37%)
acsl4	XP_031747938.1	LC_FACS_euk1	121..696	CDD:341294	278/580 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	461	1.000	Domainoid score	I477
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I789
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141523at33208
OrthoFinder	1	1.000	-	-		FOG0001203
OrthoInspector	1	1.000	-	-		otm47494
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X593
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060