DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acsl and acsbg1

DIOPT Version :9

Sequence 1:	NP_001260810.1	Gene:	Acsl / 46068	FlyBaseID:	FBgn0263120	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_001344904.2	Gene:	acsbg1 / 100006023	ZFINID:	ZDB-GENE-110914-219	Length:	674	Species:	Danio rerio

Alignment Length:	717	Identity:	165/717 - (23%)
Similarity:	295/717 - (41%)	Gaps:	139/717 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 MLQENIDTLEKVFNYV----AKTYTSKRCLGTRQILSEE--------------DEVQQNGRVFKK 138
            :|::|:  :|:|....    |::..:....|:.|:..:|              :.||:.|.:...
Zfish    13 LLEKNV--IEEVLACAKLAPAQSLWTTEASGSVQLRMDEHCPEQPITVHQMFYNSVQKYGNLTAL 75

  Fly   139 YNLGDYKWK--TFTEAERTAANFGRGLRELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIVTV 201
            .:....||:  ||.|.........:|..:||.:....:.|.....|||.|||.|.......:..:
Zfish    76 ASKRGNKWEKATFLEYYHLCRMAAKGFLKLGLEQFHGVAILGFNSAEWFIAAVGTVFAGGIMAGI 140

  Fly   202 YATLGDDGVAHCITETEVTTVITSHD-LLPKFKTLLDKCPLVKTIIYIEDQLQKTETTGFKEGVK 265
            |.|...|...|...::....::..:. .|.|...:.||.|.:|.|:.....|:       ::...
Zfish   141 YTTNSPDACLHVANDSRANVIVVENQKQLDKIMQVKDKLPHLKAIVQYSGSLK-------EKLAN 198

  Fly   266 ILPFNQVVKTG---QDSKFEHVPPK--GDDIAIIMYTSGSTGTPKGVLLSHKNCI-----ATMKG 320
            :..:.:.::.|   .|.:.:.|..|  .:...:::||||:||:||||:|||.|..     |:..|
Zfish   199 LYSWEEFMELGLEVSDHELDEVISKQRANQCCVLIYTSGTTGSPKGVMLSHDNITWTAHHASRAG 263

  Fly   321 FVDMVPI-YPDDVLIGFLPLAHVFELVAESVCLMTGV----PIGYSTP----LTLIDTSSKIKRG 376
              ||.|. ...:.|:.:|||:|:   .|:...|.||:    .|.::.|    .||:|:..::
Zfish   264 --DMQPAEIRQESLVSYLPLSHI---AAQIYDLWTGIKWGEQISFAQPDALKGTLVDSLREV--- 320

  Fly   377 CKGDATVLKPTCMTSVPLILDRISKGINDKVNSGSAFKKSLFKFLYQYKVKWV------------ 429
                    .||....||.:.::|.:.|.:.::.....|:.:        |.|.
Zfish   321 --------TPTAHMGVPRVWEKIMEKIKEGISRCGYMKRKM--------VTWAMSVSLDANQRLK 369

  Fly   430 ---QRGYKTPLIDKLVFKKVAKLMGGKVRI-IMSGGAPLSADTHEQIKTCLCLELIQGYGLTETT 490
               ::.:...|.:||:.:|:...:|....: ..||.||:..:| .|....|.:.|.:.||::| |
Zfish   370 KDEEKSFLFTLAEKLILQKLRAELGFSSCVKFFSGAAPIGRET-LQFFLGLNIRLYEAYGMSE-T 432

  Fly   491 SGATVMD----YRDMTYGRTGGPLTVCDIRLVNWE-EGNYRVTNKPYPQGEVLIGGECVSQGYYK 550
            ||...|.    |:.::.|:.   :..|..:|:|.. :|:          |||...|..|..|:..
Zfish   433 SGPHFMSGPEAYQFLSCGKV---VPGCQYKLININADGS----------GEVCFWGRNVFMGFLN 484

  Fly   551 LPGKTNEDFFEEDGQRWFKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLGKVESELK-TCGI 614
            |..||.| ..:|||  |.::||:|::..||.:.|..|.|:|:....||.:....:|..:| ...|
Zfish   485 LEDKTKE-ALDEDG--WLRSGDLGKVDEDGFIYINGRIKELIITAGGENIPPLPIEDAVKQELSI 546

  Fly   615 IENICVYGDPTKQYTVALVVP---NQNHLE----------ELAQKHGLGDKSFEELC--SSPIIE 664
            |.|..:.||..|..::.|.:.   |....|          |..|:.|.......::.  ...::.
Zfish   547 ISNAMLIGDERKFLSMLLTLKCTVNPETTEPTDILSLEAVEFCQRIGSQSTKLSDITGGKDKLVY 611

  Fly   665 KAILKEIAEHARKC-----KLQKYEVPAAITLCKEVWSPDMGLVTAAFKLKRKDIQDRYQHDINR 724
            |:|...|.:...|.     ::||:      |:..:.:|...|.:....||:|..:...|.::|..
Zfish   612 KSIEDGIGQVNSKATSNAQRIQKW------TILDKDFSVAGGELGPTMKLRRPVVLQMYHNEIEN 670

  Fly   725 MY 726
            .|
Zfish   671 FY 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acsl	NP_001260810.1	PLN02387	95..727	CDD:215217	164/714 (23%)
Acsl	NP_001260810.1	LC-FACS_euk	142..726	CDD:213293	153/647 (24%)
acsbg1	XP_001344904.2	FAA1	60..674	CDD:223953	157/668 (24%)
acsbg1	XP_001344904.2	ACSBG_like	78..672	CDD:213299	153/648 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810