DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYBPC2 and hbs

DIOPT Version :9

Sequence 1:	NP_004524.3	Gene:	MYBPC2 / 4606	HGNCID:	7550	Length:	1141	Species:	Homo sapiens
Sequence 2:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	1047	Identity:	203/1047 - (19%)
Similarity:	343/1047 - (32%)	Gaps:	315/1047 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   246 KKAKVEVKKSAAFTKKLDPAYQVDRGNKIKLMVEISDPDLTLKWFKNGQEIKPSSKYVFENVGKK 310
            :.|:|||::....|              :..:.|.::|...:.||:....:..:..........|
  Fly   151 RNARVEVEERQNLT--------------LHCIAENANPAAEIVWFQGEVPVSTAPIVTVNQTAPK 201

Human   311 RILTINKCTL---ADDAAYEVAVKDE----------KCFTELFVKEPPVLIVTPL-----EDQQV 357
            |..|.:...|   |:|...|.:.:..          :...:|.|..||   ..|.     :.:.:
  Fly   202 RFTTSSTLHLQPRAEDDYKEFSCEARHKALPPDVPMRAQVQLSVLYPP---GAPFFEGYSQGETL 263

Human   358 FVGDRVEMAVEVSEEG---AQVMWMKDGVELTREDSFKAR-----YRFKKDGKRHILIFSDVVQE 414
            ..|..|::|.. |..|   ||:.|.::||.::.......|     |:|            ....|
  Fly   264 HRGQEVQIACR-SRGGNPPAQLTWYRNGVAISSPQRTSGRLSENVYKF------------TAAAE 315

Human   415 DRGRYQVITNGGQCEAELIV------EEKQLEVLQDIADLTVKASEQAVFKCEVSDEKVTGKWYK 473
            |.|...|      |||:.::      .|..|.||....|:.:..:.||.....|....||
  Fly   316 DNGANLV------CEAKNLLATTPLRAELNLTVLYAPKDVYLSGANQAKVGDSVQLSCVT----- 369

Human   474 NGVEVRPSKRITISHVGRFHKLVIDDVRPEDEGDY-------------------------TFVPD 513
              ....|..||:.|..|          ||.|...|                         ||:..
  Fly   370 --APSNPQARISWSING----------RPLDNSTYKTTSSSDGGWVSSSNISLTIDSQSRTFIAV 422

Human   514 GYALSLSAKLNFL---EIKVEYVPKQEPPKIHLDCSGKTSEN-AIVVVAGNKLRLDVSIT-GEPP 573
            .:||:.....|.:   .:.|.|.|  .||.:       |..| ..::::|:.|:|..|.. |.||
  Fly   423 CHALNTELTQNVVGSHTVNVLYPP--SPPLL-------TGYNDGDILISGSILKLQCSSAGGNPP 478

Human   574 PVATWLKGDEVFTTTEGRTRIEKRVDCS-----SFVIESAQREDEGRYTIKVTNPVGEDVASIFL 633
            |...|.|.|::....      .|.||..     |.::.::  ::...|..||.| ...|:.....
  Fly   479 PTLQWYKNDKIINAP------SKLVDSKITSELSLLVNAS--DNNAIYKCKVQN-AAIDIPLFAT 534

Human   634 QVVDVPDPPEAVRITSVGEDW-----AILVWE-----PP----MYDGGKPVTGYLVERKK---KG 681
            :.:.|..|||.|:|:.|.::.     |.|:.:     ||    .:..|.||.|..:..:.   .|
  Fly   535 KTLGVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNPPAKISWWKDGIPVEGLNLANRPGLWGG 599

Human   682 SQRWMKL-----------------NFEVFTETTYESTKMIEGILY---------------EMRVF 714
            |...:::                 :.||...:.:|:..:  .|||               |...|
  Fly   600 SVSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHETISL--DILYPPKFETPQSTTFVGVEGAPF 662

Human   715 AVNAIGVSQPSMN----TKPFMPIAPTSEPLHLIVEDVTDTTTTLKWRPPNRIGAGGIDGYLVEY 775
            .|..:....|.:.    ||..:||:..|.....::.|......       :|:.......|:.|.
  Fly   663 HVELLASGNPMVITYTWTKDGLPISSNSLSGQRLISDGPRLNI-------SRLSRNDAGVYICEA 720

Human   776 C---------LEGSEEWVPANT----------------------EPVE-------RCGF-----T 797
            .         ::.:.|:.|..|                      .|:|       |.|:     |
  Fly   721 LNSQGTALLEIQVAVEYAPTITAVSEGRSFVAGEPAVLACHIQARPLEAAHVRWSRDGYDLATRT 785

Human   798 VKNLPTGARILFRVVGVN---------IAGRSEPATLAQPVTIREIAEPPKIRLPRHLRQTYIRK 853
            :.:...|..:| ::..|.         |......|..||.|.:.....|.....|...|  |..:
  Fly   786 ISSFENGTALL-QIASVERSDIGNFTCIVDNQRGAPAAQNVLLVVQTAPEIDHSPGFTR--YAAR 847

Human   854 VGEQLNLVVPFQGKPRPQVVWTKGGAPLDTSRVH--------VRTSDFDTVFFVRQAARSDSGEY 910
            :|.:..|:......|:|..:|.:.|..|...|.:        |...:|::...:...:..|.|:|
  Fly   848 LGVRAQLICRSLASPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFESALLIENTSPDDYGQY 912

Human   911 ELSVQIENMKDTATIRIRVVEKAGPPINVMVKEVWGTNALVEWQAPKDDGNSEIMGYFVQKADKK 975
            |..|:....:.:.|:......:...|:.:.|..|..|...:.| .|..||..:.  ||..:..:.
  Fly   913 ECVVRNSLGQASTTLEFSKPSRPDAPLQLRVGNVSDTGVDLNW-TPGFDGGMQT--YFRLRLKQH 974

Human   976 TMEWFN-VYERNRHTSCTVSDLIVGNEYYFRVYTENICG---------LSDSPGVSKNTARILKT 1030
            ..:.:. |..:..|.:.::..|..|..|||.|...|..|         |:.|.|...::|
  Fly   975 GEDKYKYVDAKPGHQNISLDGLKPGATYYFSVMAANEAGGSKFMPDIKLTLSKGSQPHSA----- 1034

Human  1031 GITFKPFEYKEHDFRMAPKFLTPLIDRVVVAGYSAA------LNCAVRGHPKPKVVWM----KNK 1085
                   ||.|.|          .:..|::.|.::|      ||.|:       |.|.    :||
  Fly  1035 -------EYTEKD----------ELPNVMIIGITSAAMVLLVLNAAL-------VAWFVIRRQNK 1075

Human  1086 MEIREDP 1092
            .:...:|
  Fly  1076 SQSEAEP 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYBPC2	NP_004524.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62
		IG_like	58..153	CDD:214653
		I-set	258..342	CDD:254352	13/96 (14%)
		Ig	283..330	CDD:299845	10/49 (20%)
		I-set	348..434	CDD:254352	21/98 (21%)
		Ig	374..441	CDD:143165	17/77 (22%)
		IG_like	447..>509	CDD:214653	15/86 (17%)
		Ig	456..>509	CDD:143165	13/77 (17%)
		Ig_C5_MyBP-C	550..635	CDD:143302	21/91 (23%)
		IG_like	554..635	CDD:214653	20/86 (23%)
		FN3	639..725	CDD:238020	25/134 (19%)
		FN3	738..830	CDD:238020	20/143 (14%)
		IG_like	848..929	CDD:214653	17/88 (19%)
		Ig_Titin_like	857..929	CDD:143225	15/79 (19%)
		FN3	934..1016	CDD:238020	21/91 (23%)
		I-set	1048..1137	CDD:254352	11/55 (20%)
		Ig	1067..1132	CDD:143165	8/30 (27%)
hbs	NP_001286439.1	Ig	44..122	CDD:299845
		IG_like	45..137	CDD:214653
		Ig	153..231	CDD:299845	16/91 (18%)
		IG_like	258..342	CDD:214653	22/102 (22%)
		Ig	266..327	CDD:299845	20/79 (25%)
		IG_like	357..>414	CDD:214653	13/73 (18%)
		Ig	360..427	CDD:299845	15/83 (18%)
		Ig	<468..526	CDD:299845	17/66 (26%)
		I-set	547..633	CDD:254352	14/85 (16%)
		Ig	556..631	CDD:299845	12/74 (16%)
		I-set	644..735	CDD:254352	13/97 (13%)
		IGc2	668..725	CDD:197706	10/63 (16%)
		IG_like	751..829	CDD:214653	13/78 (17%)
		IGc2	753..815	CDD:197706	9/62 (15%)
		Ig	852..928	CDD:143165	15/75 (20%)
		FN3	935..1017	CDD:238020	20/84 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000