Protein Alignment Sply and DPL1

DIOPT Version :9

• Sequence 1: NP_652032.1
• Gene: Sply / 46059
• FlyBaseID: FBgn0010591
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: NP_010580.1
• Gene: DPL1 / 851888
• SGDID: S000002702
• Length: 589
• Species: Saccharomyces cerevisiae
• Alignment Length: 498
• Identity: 216/498 - (43%)
• Similarity: 300/498 - (60%)
• Gaps: 20/498 - (4%)

  Fly    54 YIRGKRQFFKFAKKIPAVRRQVETELAKAKNDFETEIKKSNAHLTYSETLPEKGLSKEEILRLVD 118
            |....|:.|::....|.:|..||.|:.|.|...|.|:.:|::.|.....||..|:.::::   ::
Yeast    89 YEHSSRRLFRWLLDSPFLRGTVEKEVTKVKQSIEDELIRSDSQLMNFPQLPSNGIPQDDV---IE 150

  Fly   119 EHLKTG----HYNWRDGRVSGAVYGYKPDLVELVTEVYGKASYTNPLHADLFPGVCKMEAEVVRM 179
            |..|..    |..|::|:||||||....||:.|.|..|.|....|.||.|:||.|.|||:|||.|
Yeast   151 ELNKLNDLIPHTQWKEGKVSGAVYHGGDDLIHLQTIAYEKYCVANQLHPDVFPAVRKMESEVVSM 215

  Fly   180 ACNLFHGNS-ASCGTMTTGGTESIVMAMKAYRDFAREYKGITRPNIVVPKTVHAAFDKGGQYFNI 243
            ...:|:..| ..|||.|:|||||:::|..:.:.:|..::|||.|.|:.|.|.||.|||...||.:
Yeast   216 VLRMFNAPSDTGCGTTTSGGTESLLLACLSAKMYALHHRGITEPEIIAPVTAHAGFDKAAYYFGM 280

  Fly   244 HVRSVDVDPETYEVDIKKFKRAINRNTILLVGSAPNFPYGTIDDIEAIAALGVKYDIPVHVDACL 308
            .:|.|::||.||:||:.|.|:.||:|||||||||||||:|..||||.:..:..||.:|:|||:||
Yeast   281 KLRHVELDPTTYQVDLGKVKKFINKNTILLVGSAPNFPHGIADDIEGLGKIAQKYKLPLHVDSCL 345

  Fly   309 GSFVVALVRNAGYKLRP-FDFEVKGVTSISADTHKYGFAPKGSSVILYSDKKYKDHQFTVTTDWP 372
            |||:|:.:..||||..| .||.|.||||||.|||||||||||||||:|.:...:.||:.|...|.
Yeast   346 GSFIVSFMEKAGYKNLPLLDFRVPGVTSISCDTHKYGFAPKGSSVIMYRNSDLRMHQYYVNPAWT 410

  Fly   373 GGVYGSPTVNGSRAGGIIAACWATMMSFGYDGYLEATKRIVDTA----RYIERGVRDIDGIFIFG 433
            ||:|||||:.|||.|.|:..|||||::.|.:||:|:.:.||..|    :||:..:.|::   |.|
Yeast   411 GGLYGSPTLAGSRPGAIVVGCWATMVNMGENGYIESCQEIVGAAMKFKKYIQENIPDLN---IMG 472

  Fly   434 KPATSVIALGSNVFDIFRLSDSLCKLGWNLNALQFPSGIHLCVTDM--HTQPGVADKFIADVRSC 496
            .|..|||:..|...:|..|||.|.|.||:.||||.|..:|:..|.:  |....:.|.....|:..
Yeast   473 NPRYSVISFSSKTLNIHELSDRLSKKGWHFNALQKPVALHMAFTRLSAHVVDEICDILRTTVQEL 537

  Fly   497 TAEIMKDPGQPVVGKMALYGMAQSIPDRSVIGEVTRLFLHSMY 539
            .:|....|...  |..||||:|.|:....|..::...||.::|
Yeast   538 KSESNSKPSPD--GTSALYGVAGSVKTAGVADKLIVGFLDALY 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sply	NP_652032.1	DOPA_deC_like	132..494	CDD:99743	180/369 (49%)
DPL1	NP_010580.1	GadA	106..543	CDD:223154	200/442 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344851
Domainoid	1	1.000	303	1.000	Domainoid score	I217
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2897
Inparanoid	1	1.050	404	1.000	Inparanoid score	I311
Isobase	1	0.950	-	0.875	Normalized mean entropy	S949
OMA	1	1.010	-	-		QHG61533
OrthoFinder	1	1.000	-	-		FOG0004289
OrthoInspector	1	1.000	-	-		oto99164
orthoMCL	1	0.900	-	-		OOG6_101412
Panther	1	1.100	-	-	LDO	PTHR42735
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2292
SonicParanoid	1	1.000	-	-		X3547
TreeFam	1	0.960	-	-
	16	15.740