DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sply and gad2

DIOPT Version :9

Sequence 1:	NP_652032.1	Gene:	Sply / 46059	FlyBaseID:	FBgn0010591	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001017708.2	Gene:	gad2 / 550403	ZFINID:	ZDB-GENE-030909-9	Length:	583	Species:	Danio rerio

Alignment Length:	433	Identity:	88/433 - (20%)
Similarity:	158/433 - (36%)	Gaps:	100/433 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 AKKIPAVRRQVETELAKAKNDFETEIKKSNAHLTYS-------------ETLPEKGLSKEEILRL 116
            ||.:..::..|:..||.....|:...|..:.|....             |||.:..:|....|:.
Zfish   103 AKTMNFLQEVVDILLAYIVESFDRSTKVIDFHYPNELLQRNNWELSDEPETLDDILISCRATLKY 167

  Fly   117 VDEHLKTGHYNWRDGRVSGAVYGYKPDLVELVTEVYGKASYTNPLHADLFPGVCKMEAEVVRMAC 181
            .   :||.|..:.:...:|.      |:|.|..:.....:.||....::.|....:|...::...
Zfish   168 A---IKTAHPRYFNQLSTGL------DMVGLAADWLTSTANTNMFTYEVAPVFVLLEYVTLKKMR 223

  Fly   182 NLF-----HGNSASCGTMTTGGTESIVMAM--KAYRDFAR-EYKGITR-PNIVVPKTVHAAFD-- 235
            .:.     ||:    |..:.||..|.:.||  ..|:.|.. :.||::. |.:|...:.|:.|.
Zfish   224 EIIGWQDGHGD----GIFSPGGAISNMYAMLLARYKMFPEVKEKGMSSVPRLVAFTSEHSHFSIK 284

  Fly   236 KGGQYFNIHVRSVDVDPETYEVDIKKFKRA------INRNTI----------LLVGSAPNFPYGT 284
            ||.....|...||        :.||..:|.      :.|..|          .:..:|....||.
Zfish   285 KGAAALGIGTESV--------ICIKADERGKMIPSDLERRIIEAKQKGYVPFFVSATAGTTVYGA 341

  Fly   285 IDDIEAIAALGVKYDIPVHVDACLGSFVVALVRNAGYKLRPFDFEVKGVTSISADTHKYGFAPKG 349
            .|.:.|||.:..|:|:.:|||...|..:: :.|...:||.    .|:...|::.:.||....|..
Zfish   342 FDPLIAIADICKKHDVWMHVDGAWGGSLL-MSRKHRWKLN----GVERANSMTWNPHKMMAVPLQ 401

  Fly   350 SSVI------------------LYSDKKYKDHQFTVTTDWPGGVYGSPTVNGSRAGGI--IAACW 394
            .|.:                  |:...|:.|.|:..         |...:...|...|  :...|
Zfish   402 CSALLVREEGLMQSCNQMQACYLFQQDKHYDLQYDT---------GDKALQCGRHVDIFKLWLMW 457

  Fly   395 ATMMSFGYDGYLEATKRIVDTARYIERGVRDIDGI-FIF-GKP 435
            ....:.|::..::   :.::.:.|:...::|.:|. .:| |||
Zfish   458 RAKGTIGFEAQID---KCLELSEYLYNKIKDREGYQMVFDGKP 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sply	NP_652032.1	DOPA_deC_like	132..494	CDD:99743	72/353 (20%)
gad2	NP_001017708.2	Pyridoxal_deC	136..506	CDD:278699	80/400 (20%)
gad2	NP_001017708.2	TIM_phosphate_binding	511..>561	CDD:304361
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900