DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sply and Sgpl1

DIOPT Version :9

Sequence 1:	NP_652032.1	Gene:	Sply / 46059	FlyBaseID:	FBgn0010591	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	XP_008771093.2	Gene:	Sgpl1 / 286896	RGDID:	628599	Length:	648	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	271/558 - (48%)
Similarity:	369/558 - (66%)	Gaps:	22/558 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RPFSGSDCLK-----PVTEGINRAFGAK------------EPWQVATITATTVLGGVWLWTVICQ 49
            |....:|.||     |..| |..|:..|            ||||:...:....|..||::.:|.|
  Rat    79 RKMPSTDLLKLKDFEPYLE-ILEAYSTKAKNYVNGYCTKYEPWQLIAGSVLCTLLVVWVYELIFQ 142

  Fly    50 DENLYIRGKRQFFKFAKKIPAVRRQVETELAKAKNDFETEIKKSNAHLTYSETLPEKGLSKEEIL 114
            .|:|:.|.|.:.|:..:|:|.:.|:::.:|.|||.|....:........|.:|||.:|||..|:|
  Rat   143 PESLWSRFKNKLFRLIRKMPFIGRKIQQQLTKAKKDLVKNMPFLKLDKDYVKTLPAQGLSTAEVL 207

  Fly   115 RLVDEHLKTGHYNWRDGRVSGAVYGYKPDLVELVTEVYGKASYTNPLHADLFPGVCKMEAEVVRM 179
            ..:.|:.....: |::|:.|||||..:|.|.||:.:.||:.:::||||.|:|||:.|:|||:|||
  Rat   208 ERLKEYSSMDVF-WQEGKASGAVYSGEPKLTELLVQAYGEFTWSNPLHPDIFPGLRKLEAEIVRM 271

  Fly   180 ACNLFHGNSASCGTMTTGGTESIVMAMKAYRDFAREYKGITRPNIVVPKTVHAAFDKGGQYFNIH 244
            .|:||:|...|||.:|:||||||:||.|||||.|.| |||..|.||.|::.||||||...||.:.
  Rat   272 TCSLFNGGPDSCGCVTSGGTESILMACKAYRDLALE-KGIKTPEIVAPESAHAAFDKAAHYFGMK 335

  Fly   245 VRSVDVDPETYEVDIKKFKRAINRNTILLVGSAPNFPYGTIDDIEAIAALGVKYDIPVHVDACLG 309
            :..| ...:..|||::..||||:|||.:||.|||.||:|.||.|..:|.|.|||.||.|||||||
  Rat   336 IVRV-AQKKNMEVDVRAMKRAISRNTAMLVCSAPQFPHGVIDPIPEVAKLAVKYKIPFHVDACLG 399

  Fly   310 SFVVALVRNAGYKL-RPFDFEVKGVTSISADTHKYGFAPKGSSVILYSDKKYKDHQFTVTTDWPG 373
            .|::..:..|||.| :||||.|||||||||||||||:|||||||::||::||:.:||.|..||.|
  Rat   400 GFLIVFMEKAGYPLEKPFDFRVKGVTSISADTHKYGYAPKGSSVVMYSNEKYRKYQFFVDADWQG 464

  Fly   374 GVYGSPTVNGSRAGGIIAACWATMMSFGYDGYLEATKRIVDTARYIERGVRDIDGIFIFGKPATS 438
            |:|.||::.|||.|||||||||.:|.||.:||:||||:|:.|||:::..:.:|..|||.|.|..|
  Rat   465 GIYASPSIAGSRPGGIIAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKNIFILGDPQLS 529

  Fly   439 VIALGSNVFDIFRLSDSLCKLGWNLNALQFPSGIHLCVTDMHTQPGVADKFIADVRSCTAEIMKD 503
            |||||||.|||:|||:.:...|||.|.||||..||.|:|.:||:..||.:|:.|:|....:|||:
  Rat   530 VIALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIHFCITLVHTRKRVAIQFLKDIRESVTQIMKN 594

  Fly   504 PGQPVVGKMALYGMAQSIPDRSVIGEVTRLFLHSMYYT 541
            |.....|..|:|||||:..||.::.|::.:||.|:|.|
  Rat   595 PKAKTTGMGAIYGMAQATIDRKMVAEISSVFLDSLYST 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sply	NP_652032.1	DOPA_deC_like	132..494	CDD:99743	208/362 (57%)
Sgpl1	XP_008771093.2	DOPA_deC_like	226..587	CDD:99743	209/362 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346213
Domainoid	1	1.000	323	1.000	Domainoid score	I1176
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2897
Inparanoid	1	1.050	535	1.000	Inparanoid score	I1159
OMA	1	1.010	-	-		QHG61533
OrthoDB	1	1.010	-	-		D299321at33208
OrthoFinder	1	1.000	-	-		FOG0004289
OrthoInspector	1	1.000	-	-		oto95964
orthoMCL	1	0.900	-	-		OOG6_101412
Panther	1	1.100	-	-	LDO	PTHR42735
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3547
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770