DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sply and GAD1

DIOPT Version :9

Sequence 1:NP_652032.1 Gene:Sply / 46059 FlyBaseID:FBgn0010591 Length:545 Species:Drosophila melanogaster
Sequence 2:NP_000808.2 Gene:GAD1 / 2571 HGNCID:4092 Length:594 Species:Homo sapiens


Alignment Length:519 Identity:109/519 - (21%)
Similarity:186/519 - (35%) Gaps:103/519 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 NLYIR-------GKRQFFKFAKKIPAVRRQVETELAKAKNDFETEIKKSNAHLT---------YS 100
            ||:.|       |:.|..:|..::      |:..|...:..|:...|..:.|..         ::
Human    97 NLFARDLLPAKNGEEQTVQFLLEV------VDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFN 155

  Fly   101 ETLPEKGLSKEEILRLVDEHLK----TGHYNWRDGRVSGAVYGYKPDLVELVTEVYGKASYTNPL 161
            ..|.:...|.|:||....:.||    |||..:.:...:|.      |::.|..|.....:.||..
Human   156 LELSDHPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGL------DIIGLAGEWLTSTANTNMF 214

  Fly   162 HADLFPGVCKMEAEVVRMACNLFHGNSA-SCGTMTTGGTESIVMAMKAYR-DFAREYKGITRPNI 224
            ..::.|....||...::....:...:|. ..|..:.||..|.:.::.|.| .:..|.|  |:...
Human   215 TYEIAPVFVLMEQITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVK--TKGMA 277

  Fly   225 VVPKTV-------HAAFDKGGQYFNIHVRSV---------DVDPETYEVDIKKFKRA------IN 267
            .|||.|       |.:..|.|........:|         .:.|..:|..|.:.|:.      :|
Human   278 AVPKLVLFTSEQSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVN 342

  Fly   268 RNTILLVGSAPNFPYGTIDDIEAIAALGVKYDIPVHVDACLGSFVVALVRNAGYKLRPFDFEVKG 332
                   .:|....||..|.|:.||.:..||::.:||||..|..:: :.|...:||.    .::.
Human   343 -------ATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLL-MSRKHRHKLN----GIER 395

  Fly   333 VTSISADTHKYGFAPKGSSVILYSDKK--------------YKDHQFTVTTDWPGGVYGSPTVNG 383
            ..|::.:.||........|.||..:|.              ..|.|:.|:.|     .|...:..
Human   396 ANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYD-----TGDKAIQC 455

  Fly   384 SRAGGIIAACWATMMSFGYDGYLEATKRIVDTARYIERGVRDIDGI-FIF-GKPATSVIALG--- 443
            .|...|. ..|....:.|..|:.....:.::.|.|:...:::.:.. .:| |:|..:.:...   
Human   456 GRHVDIF-KFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIP 519

  Fly   444 ---SNVFDIFRLSDSLCKLGWNLNALQFPSGIHLCVTDMHTQP-GVADKFIADVRSCTAEIMKD 503
               ..|.|..:..:.|.|:...:.||...||    .|.:..|| |....|...|.|..|....|
Human   520 QSLRGVPDSPQRREKLHKVAPKIKALMMESG----TTMVGYQPQGDKANFFRMVISNPAATQSD 579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SplyNP_652032.1 DOPA_deC_like 132..494 CDD:99743 84/408 (21%)
GAD1NP_000808.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Pyridoxal_deC 144..518 CDD:365998 81/399 (20%)
Substrate binding 190..192 0/1 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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