Protein Alignment Sply and spl-2

DIOPT Version :9

• Sequence 1: NP_652032.1
• Gene: Sply / 46059
• FlyBaseID: FBgn0010591
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: NP_505372.1
• Gene: spl-2 / 181859
• WormBaseID: WBGene00006418
• Length: 542
• Species: Caenorhabditis elegans
• Alignment Length: 521
• Identity: 221/521 - (42%)
• Similarity: 327/521 - (62%)
• Gaps: 23/521 - (4%)

  Fly    30 ATITATTVLGGVWLWTVICQDENLYIRGKRQ-----FFKFAKKIPAVRRQVETELAKAKNDFETE 89
            :||.||.||..:       :..:|...|.|:     ||...|::|.:|:.::.:|.:.|::.|..
 Worm    30 STIVATYVLTNL-------RHMHLDEMGIRKRLSTWFFTTVKRVPFIRKMIDKQLNEVKDELEKS 87

  Fly    90 IKKSNAHLTYSETLPEKGLSKEEILRLVDEHLKTGHYNWRDGRVSGAVYGYKPDL--VELVTEVY 152
            ::..:....|..|:|...:.:.|:|||...:.......:.:|||||||:..:.|.  .|:..||:
 Worm    88 LRIVDRSTEYFTTIPSHSVGRTEVLRLAAIYDDLEGPAFLEGRVSGAVFNREDDKDEREMYEEVF 152

  Fly   153 GKASYTNPLHADLFPGVCKMEAEVVRMACNLFHGNSASCGTMTTGGTESIVMAMKAYRDFAREYK 217
            ||.::||||...|||||..||||||||.||:.:|:|.:||||:|||:.||::|..|:|:...: :
 Worm   153 GKFAWTNPLWPKLFPGVRIMEAEVVRMCCNMMNGDSETCGTMSTGGSISILLACLAHRNRLLK-R 216

  Fly   218 GITRPNIVVPKTVHAAFDKGGQYFNIHVRSVDVDPETYEVDIKKFKRAINRNTILLVGSAPNFPY 282
            |.....::||.:|||||.|..:.|.|.||.:.|||.|::||:.|.|.|||:.|.:|||||||||:
 Worm   217 GEKYTEMIVPSSVHAAFFKAAECFRIKVRKIPVDPVTFKVDLVKMKAAINKRTCMLVGSAPNFPF 281

  Fly   283 GTIDDIEAIAALGVKYDIPVHVDACLGSFVVALVRNAGYKLRPFDFEVKGVTSISADTHKYGFAP 347
            ||:||||||..||::||||||||||||.|::..:.....:   :||.|.||:|||||:||||.||
 Worm   282 GTVDDIEAIGQLGLEYDIPVHVDACLGGFLLPFLEEDEIR---YDFRVPGVSSISADSHKYGLAP 343

  Fly   348 KGSSVILYSDKKYKDHQFTVTTDWPGGVYGSPTVNGSRAGGIIAACWATMMSFGYDGYLEATKRI 412
            |||||:||.:|:...:|:....||.||:|.|.|:.|||||..||.|||.|:....:||....::|
 Worm   344 KGSSVVLYRNKELLHNQYFCDADWQGGIYASATMEGSRAGHNIALCWAAMLYHAQEGYKANARKI 408

  Fly   413 VDTARYIERGVRDIDGIFIFGKPATSVIALGSN-VFDIFRLSDSLCKLGWNLNALQFPSGIHLCV 476
            |||.|.|..|:.:|.||.:.|.....:::..:| ..:::|..:.:.:..|.||.||||:|:|:.|
 Worm   409 VDTTRKIRNGLSNIKGIKLQGPSDVCIVSWTTNDGVELYRFHNFMKEKHWQLNGLQFPAGVHIMV 473

  Fly   477 TDMHTQPGVADKFIADVRSCTAEIMKD--PGQ-PVVGKMALYGMAQSIPDRSVIGEVTRLFLHSM 538
            |..||.||:|:.|:||.|: ..|.:|.  |.: ....:.|:||:||||||||::.|....::.::
 Worm   474 TMNHTHPGLAEAFVADCRA-AVEFVKSHKPSESDKTSEAAIYGLAQSIPDRSLVHEFAHSYIDAV 537

  Fly   539 Y 539
            |
 Worm   538 Y 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sply	NP_652032.1	DOPA_deC_like	132..494	CDD:99743	179/364 (49%)
spl-2	NP_505372.1	DOPA_deC_like	130..493	CDD:99743	180/367 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162568
Domainoid	1	1.000	77	1.000	Domainoid score	I5757
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2897
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1061
Isobase	1	0.950	-	0.875	Normalized mean entropy	S949
OMA	1	1.010	-	-		QHG61533
OrthoDB	1	1.010	-	-		D299321at33208
OrthoFinder	1	1.000	-	-		FOG0004289
OrthoInspector	1	1.000	-	-		oto18717
orthoMCL	1	0.900	-	-		OOG6_101412
Panther	1	1.100	-	-	O	PTHR42735
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2292
SonicParanoid	1	1.000	-	-		X3547
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750