Protein Alignment Sply and DDC

DIOPT Version :9

• Sequence 1: NP_652032.1
• Gene: Sply / 46059
• FlyBaseID: FBgn0010591
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: NP_000781.2
• Gene: DDC / 1644
• HGNCID: 2719
• Length: 480
• Species: Homo sapiens
• Alignment Length: 474
• Identity: 81/474 - (17%)
• Similarity: 149/474 - (31%)
• Gaps: 137/474 - (28%)

  Fly   127 NWRDGRVSGAVY-----GY-----------KPDLVE-LVTEVY-----GKASYTNPLHADLFPGV 169
            |:.:|.....||     ||           :||..| ::.:|.     |...:.:|.....||..
Human    19 NYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIMPGVTHWHSPYFFAYFPTA 83

  Fly   170 CKMEAEVVRMACNLF------HGNSASCGTMTT------------------------GG------ 198
            ....|.:..|.|...      ...|.:|..:.|                        ||
Human    84 SSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPKAFLNEKAGEGGGVIQGSA 148

  Fly   199 TESIVMAMKAYRDFAREYKGITRPNI----VVPKTV-------HAAFDKGGQYFNIHVRSVDVDP 252
            :|:.::|:.|.|...........|.:    ::.|.|       |::.::.|....:.::::..|
Human   149 SEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIPSD- 212

  Fly   253 ETYEVDIKKFKRAINRNTILLVGSAPNFPYGTI--------DDIEAIAALGVKYDIPVHVDACL- 308
            ..:.:.....:.|:.|:.  ..|..|.|...|:        |::..:..:..|.||.:||||..
Human   213 GNFAMRASALQEALERDK--AAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYA 275

  Fly   309 -GSFVVALVRNAGYKLRPFDFEVKGVTSISADTHKYGFAPKGSSVILYSDKKYKDHQFTVTTDWP 372
             .:|:....|   :.|...:|    ..|.:.:.||:.......|.:....:          ||..
Human   276 GSAFICPEFR---HLLNGVEF----ADSFNFNPHKWLLVNFDCSAMWVKKR----------TDLT 323

  Fly   373 GGVYGSPTV--NGSRAGGIIA----------------ACWATMMSFGYDGYLEATKRIVDTARYI 419
            |.....||.  :..:..|:|.                ..|.....:|..|.....::.|..:...
Human   324 GAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEF 388

  Fly   420 ERGVRDIDGIFIFGKPATSVIAL---GSNVFDIFRLSDSLCKLGWNLNALQFPSGIHLCVTDMHT 481
            |..||......|..:....::..   |||     :::::|      |..:.....|||....:.
Human   389 ESLVRQDPRFEICVEVILGLVCFRLKGSN-----KVNEAL------LQRINSAKKIHLVPCHLR- 441

  Fly   482 QPGVADKFIADVRSCTAEI 500
                 |||:.....|:..:
Human   442 -----DKFVLRFAICSRTV 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sply	NP_652032.1	DOPA_deC_like	132..494	CDD:99743	78/461 (17%)
DDC	NP_000781.2	Pyridoxal_deC	35..414	CDD:365998	65/398 (16%)
		2 X approximate tandem repeats	58..178		18/119 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810