DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sply and gad1a

DIOPT Version :9

Sequence 1:	NP_652032.1	Gene:	Sply / 46059	FlyBaseID:	FBgn0010591	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	XP_002663350.1	Gene:	gad1a / 100329827	ZFINID:	ZDB-GENE-070912-472	Length:	591	Species:	Danio rerio

Alignment Length:	569	Identity:	120/569 - (21%)
Similarity:	197/569 - (34%)	Gaps:	162/569 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 NLYIR-------GKRQFFKFAKKIPAVRRQVETELAKAKNDFETEIKKSNAHLT---------YS 100
            |||.|       |:....:|..::      ||......:..|:...|..:.|..         ::
Zfish    94 NLYARDLLPAKNGEEYTMQFLLEV------VEILTNYVRKTFDRSTKVLDFHHPHQLLEGMEGFN 152

  Fly   101 ETLPEKGLSKEEILRLVDEHLK----TGHYNWRDGRVSGAVYGYKPDLVELVTEVYGKASYTNPL 161
            ..|.::..|.|:||....:.||    |||..:.:...||.      |::.|..|.....:.||..
Zfish   153 LELCDQPESLEQILVDCRDTLKYGVRTGHPRFFNQLSSGL------DIIGLAGEWLTSTANTNMF 211

  Fly   162 HADLFPGVCKME-------AEVVRMACNLFHGNSASCGTMTTGGTES-----IVMAMKAYRDFAR 214
            ..::.|....||       .|:|...      |....|..:.||..|     :|...|.|.:.
Zfish   212 TYEIAPVFVLMEQLTLKKMREIVGWP------NGEGDGIFSPGGAISNMYSVMVARYKHYPEI-- 268

  Fly   215 EYKGI-TRPNIVVPKTVHAAF---------------------DKGGQYFNIHVRSVDVDPETYEV 257
            :.||: ..|.:|:..:.|:.:                     |:.|       |.:..|.|...:
Zfish   269 KIKGMAAAPRLVLFTSEHSHYSIKKASAVLGFGTENLILLRTDERG-------RVIPADLEAKVI 326

  Fly   258 DIKK------FKRAINRNTILLVGSAPNFPYGTIDDIEAIAALGVKYDIPVHVDACLGSFVVALV 316
            |.|:      |..|...:|:          ||..|.|..||.:..||::.:|||...|..:: :.
Zfish   327 DAKQKGFVPMFVNATAGSTV----------YGAFDPINEIADICEKYNMWLHVDGAWGGGLL-MS 380

  Fly   317 RNAGYKLRPFDFEVKGVTSISADTHKYGFAPKGSSVILYSDKK--------------YKDHQFTV 367
            |...:||.    .::...|::.:.||....|...|.||..:|.              ..|.|:.|
Zfish   381 RKHKHKLS----GIERANSVTWNPHKMMGVPLQCSAILVREKGLLQGCNSMCAGYLFQPDKQYDV 441

  Fly   368 TTDWPGGVYGSPTVNGSRAGGIIAACWATMMSFGYDGYLEATKRIVDTARYIERGVRDIDGI-FI 431
            |.|     .|...:...|...|. ..|....|.|..|:.:...|.::.:.|:...:::.:|. .:
Zfish   442 TYD-----TGDKAIQCGRHVDIF-KFWLMWKSKGTTGFEKHIDRCLELSEYLYHKIKNREGYEMV 500

  Fly   432 F-GKPATSVIALGSNVFDIFRLSDSLCKLGWNLNALQFPSGIHLCVTD----MHTQPGVADKFIA 491
            | |:|..:.:..                  |.:     |..:.| :.|    .|....||.|..|
Zfish   501 FQGEPQHTNVCF------------------WYI-----PPSLRL-LPDGEEKRHRLHKVAPKIKA 541

  Fly   492 DVRSCTAEIMKDPG-QPVVGKMALYGMAQSIP--DRS----VIGEVTRL 533
            .:..|...::   | ||...|:..:.|..|.|  .||    :|.|:.||
Zfish   542 LMMECGTTMV---GYQPQGEKVNFFRMVVSNPAVTRSDIDFLIDEIERL 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sply	NP_652032.1	DOPA_deC_like	132..494	CDD:99743	85/421 (20%)
gad1a	XP_002663350.1	Pyridoxal_deC	141..515	CDD:278699	87/433 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910