DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sply and sgpl1

DIOPT Version :9

Sequence 1:	NP_652032.1	Gene:	Sply / 46059	FlyBaseID:	FBgn0010591	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	XP_005156777.1	Gene:	sgpl1 / 100037312	ZFINID:	ZDB-GENE-070410-24	Length:	574	Species:	Danio rerio

Alignment Length:	529	Identity:	281/529 - (53%)
Similarity:	377/529 - (71%)	Gaps:	1/529 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 INRAFGAKEPWQVATITATTVLGGVWLWTVICQDENLYIRGKRQFFKFAKKIPAVRRQVETELAK 81
            :|......||||:...|..:.||.|||...:.|.|:|..|.|:|||:..:|||.:...::.:|.|
Zfish    27 VNSQCAGLEPWQIIAATLLSTLGVVWLKDFLFQQESLTSRVKKQFFRIIRKIPFIGASIQNQLNK 91

  Fly    82 AKNDFETEIKKSNAHLTYSETLPEKGLSKEEILRLVDEHLKTGHYNWRDGRVSGAVYGYKPDLVE 146
            |.:|....:......::|::.||.:||:.:::|..:.|:......||..|:||||||.....|.:
Zfish    92 ALDDMSMSLCTLKEGMSYTKLLPAQGLTHKQLLDKIREYETLSEVNWAKGKVSGAVYWGDEKLTD 156

  Fly   147 LVTEVYGKASYTNPLHADLFPGVCKMEAEVVRMACNLFHGNSASCGTMTTGGTESIVMAMKAYRD 211
            |:.:|||:.::|||||.|:||||.|||||||||.|.||:|...||||:|:||||||:||.|||||
Zfish   157 LLVKVYGEFAWTNPLHPDIFPGVRKMEAEVVRMTCALFNGGPDSCGTVTSGGTESILMACKAYRD 221

  Fly   212 FAREYKGITRPNIVVPKTVHAAFDKGGQYFNIHVRSVDVDPETYEVDIKKFKRAINRNTILLVGS 276
            .|.| :||..|.|:.|.:|||||||...||.:.:..|.:|.:|.:||:|..:|||.:||.:||.|
Zfish   222 MAHE-RGIKHPEIIAPISVHAAFDKAAHYFGMKLIHVPLDNKTMKVDVKAMRRAITKNTAMLVCS 285

  Fly   277 APNFPYGTIDDIEAIAALGVKYDIPVHVDACLGSFVVALVRNAGYKLRPFDFEVKGVTSISADTH 341
            ||.||:|.:|.:|.:|.|.|||:||.|||||||.|::..:..||:||.||||.||||||||||||
Zfish   286 APQFPHGIMDPVEEVAKLAVKYNIPFHVDACLGGFLIVFMEKAGFKLAPFDFRVKGVTSISADTH 350

  Fly   342 KYGFAPKGSSVILYSDKKYKDHQFTVTTDWPGGVYGSPTVNGSRAGGIIAACWATMMSFGYDGYL 406
            |||:|||||||:|||::|::.:|:.|..||.||:|.||::.|||.||||||||||||..|..||:
Zfish   351 KYGYAPKGSSVVLYSNRKFRHYQYFVAPDWQGGIYASPSMAGSRPGGIIAACWATMMHMGEKGYV 415

  Fly   407 EATKRIVDTARYIERGVRDIDGIFIFGKPATSVIALGSNVFDIFRLSDSLCKLGWNLNALQFPSG 471
            |||:::|:|.|.|:.|:|.|||:|:||.|..||:||||:.|||||||::|...|||||.|||||.
Zfish   416 EATRKVVETTRKIKTGIRKIDGVFVFGDPEVSVVALGSDDFDIFRLSNALTSKGWNLNTLQFPSS 480

  Fly   472 IHLCVTDMHTQPGVADKFIADVRSCTAEIMKDPGQPVVGKMALYGMAQSIPDRSVIGEVTRLFLH 536
            ||:|||.:|||.|||::||:||:...|.|||:|.:...|..|:|||||||||||::.||::.||.
Zfish   481 IHICVTMLHTQSGVAEQFISDVKKEVAIIMKNPKEKTTGMGAIYGMAQSIPDRSMVTEVSQGFLD 545

  Fly   537 SMYYTPSQK 545
            .:|.|...|
Zfish   546 CLYSTEVPK 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sply	NP_652032.1	DOPA_deC_like	132..494	CDD:99743	219/361 (61%)
sgpl1	XP_005156777.1	DOPA_deC_like	143..504	CDD:99743	220/361 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587178
Domainoid	1	1.000	358	1.000	Domainoid score	I931
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2897
Inparanoid	1	1.050	583	1.000	Inparanoid score	I977
OMA	1	1.010	-	-		QHG61533
OrthoDB	1	1.010	-	-		D299321at33208
OrthoFinder	1	1.000	-	-		FOG0004289
OrthoInspector	1	1.000	-	-		oto39832
orthoMCL	1	0.900	-	-		OOG6_101412
Panther	1	1.100	-	-	LDO	PTHR42735
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2292
SonicParanoid	1	1.000	-	-		X3547
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800