DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYBPC1 and bt

DIOPT Version :9

Sequence 1:	XP_006719468.1	Gene:	MYBPC1 / 4604	HGNCID:	7549	Length:	1195	Species:	Homo sapiens
Sequence 2:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster

Alignment Length:	1349	Identity:	323/1349 - (23%)
Similarity:	500/1349 - (37%)	Gaps:	337/1349 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     3 EPTKKEENEV-----PAPAPPPE-EPSKEKEAGTTPAKDEEEVSPP----SALPPG-LGSRAL-- 54
            :.||:|:.:|     |||..||: |..:||.....|       .||    |.:||. .|.|..
  Fly  1377 QETKEEKQKVPKMQPPAPGDPPKIEVIREKRPSLAP-------EPPSRRGSLIPPADTGRRPSLI 1434

Human    55 ---ERKDSDWTLVET---PPGEEQAKQNANSQLSIL---------FIEKP--------QGG---- 92
               |:|.....:::|   .|||....|.....:.:.         .|.||        .||
  Fly  1435 INDEKKLRPGEVMDTRLLRPGEVGEGQRRRPSIDVRRPSVQDLEDLINKPSTPLRDVGDGGPPSI 1499

Human    93 -----TVKVGEDITFIAKVKAEDLLRKPTIKWFKGKWMDLASKAGKHLQLKETFERHSRVYTFEM 152
                 :..|.||.|....|..|. ...||.|::||....|.....|.|...:|       .|..:
  Fly  1500 VDVQESYSVVEDSTAYLTVGVEG-SPAPTFKFYKGVSEILEGGRFKFLTDGQT-------NTITL 1556

Human   153 QIIKAKDNFAGNYRCEVTYKDKFDSCSFDLEVHESTGTTPNIDIRSAFKRSGEGQEDAGELDFSG 217
            .:.|.|.|....|:..|:.....||....|.|.:|:|                       :||..
  Fly  1557 CMRKCKPNDESKYKIVVSNIHGEDSAEMQLYVSDSSG-----------------------MDFRA 1598

Human   218 LLKRREVKQQEEEPQVDVWELLKNAKPSEYEKIAFQYGITDLRGMLKRLKRMRREEKKSAAF-AK 281
            :||:|..::.:::.|...|                    .||:...|.|..:::.|:|..:| :.
  Fly  1599 MLKKRRYQKWDKDEQDPNW--------------------GDLKETEKPLPALKKVERKVESFLSP 1643

Human   282 ILDPAYQVDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSE 346
            ::|...:..|..:|.|....:.|..:.||.....|:...:|:.|:.:.....|.|...::.|..:
  Fly  1644 LIDQFAKEGKDKKVVFEARFSKPNCKPKWLFRKDEVFTGSKFKFKQENDTYQLIITTPKVEDTGK 1708

Human   347 YYVTAGDEKCSTELFVRE--PPIMVTKQL-EDTTAYCGERVELECEVSEDDANVKWFKNGEEIIP 408
            |.:..|....:..|.|.|  |....||.| :....:......|||.||...|||.||||..: :.
  Fly  1709 YTIEIGGVSSTAFLNVEEADPTYTFTKPLKKKLEGFTQHETTLECSVSSSMANVHWFKNNTK-LE 1772

Human   409 GPKSRYRIRVEGKKHI-LIIEGATKADAAEY--SVMTTGGQSSAKLSVDLKPLKILTPLTDQTVN 470
            ....||.|..:...:: |||:.:...||..|  .:.....::...|.|...|.|.:..|..|...
  Fly  1773 SDDPRYLISKDINGNLKLIIKDSVLDDAGLYRCQLDKQPDKTECNLKVTEYPYKFVKVLKSQQCI 1837

Human   471 LGKEICLKCEISENI-PGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDA-- 532
            ....:.|.|||.:.: ..:|.:||..::...|:::|..||..||||.:....|.|.:....:|
  Fly  1838 EKDTVTLACEIDDAMGEVQWLRNGEEIKPDKRIQIVKDGRKRKLVIKDCKVTDAGQFKCTTNADT 1902

Human   533 ------------YNVTLPAKVHVIDPPKIILD--------------------------------- 552
                        :|..| .....::..|:|||
  Fly  1903 TESEIIINYQNRFNKKL-KDTEAVEREKLILDIELQDQTAPCDWKFNGEPIVPSESIEIKNMGGG 1966

Human   553 -------GLDADN--TVTVIAG---NKLRLEI-----------------PISG----EPPPKAMW 584
                   .||..|  .:|..:|   :|.:|.|                 |||.    |.|.|...
  Fly  1967 KHQLIFSSLDMSNEGEITCESGQLSSKCKLSIRKGESRPNIDCPDKFSGPISAPVLLEVPFKVSG 2031

Human   585 SRGD----KAIMEGS----GRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKV 641
            ::..    |...:|.    ..:......|..|..|....||.||.|.|.:.|..||....:::..
  Fly  2032 TKQTPVEAKLFKDGKPLPVKDVEVAVTDDKVTFKIKKPSRDLSGPYQIKISNGQGEDTKDVQIIC 2096

Human   642 VDFPDPPVAPTVTEVGDDWCIMNWEPPAYDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFE- 705
            .|.|.||....:|:|....|::::.||:.|||:||..|.|||:            ||.|:..:|
  Fly  2097 QDVPQPPQDVDITDVYQTSCVVSFNPPSDDGGTPITKYVIERQ------------DLSKKHGWES 2149

Human   706 ------------------PKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLLTVD 752
                              |||.     |..||.||||||.|.|:           |...|:|..|
  Fly  2150 VAEVLPSEPCLKKIDDLIPKKQ-----YRFRIRAVNAIGQSDPA-----------TFKNTILAKD 2198

Human   753 --------SVTDTT------VTMRWRPPDHIGAAGLDGYVLEYCFEGSTSAKQSDENGEAAYDLP 803
                    ...|.|      ..::|..|:..|...:..|::||        |:...|
  Fly  2199 PWDEPGKPKAVDLTDWDKDHADLKWEAPETDGGDPITAYIVEY--------KEKFSN-------- 2247

Human   804 AEDWIVANKDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPR 868
              ||:...:...|....|:.||....:...||:|||.||..||...::.|:.|.....|.| :..
  Fly  2248 --DWVSGKEVDGDARTATVDGLKEGQQYEFRVRAVNRAGPGEPSDKTKSIIAKCRFVKPFI-VGE 2309

Human   869 HLKQTYIRRVGEAVNLVIPFQGKPRPELTWKK--DGAEIDKNQINIRNSETDTIIFIRKAERSHS 931
            .||...::: |:.:...|.:.|:|.|..||.|  |..:.|..:|.:...|.::.|.|:|:.|..:
  Fly  2310 GLKNVTVKK-GQTIRFDIKYDGEPEPAATWVKGTDNLKFDNQRICLDQLERNSSITIKKSVRKDT 2373

Human   932 GKYDLQVKVDKFVETASIDIQIIDRPGPP-QIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQK 995
            |||.|.:........:...:.::|||.|| ...:.|::...::.:.|..|.|||...|:||.:::
  Fly  2374 GKYKLVLSNSSGTIESEAQVVVLDRPLPPGGPFEPEEIRASHIKMKWKRPDDDGGCEISGYALER 2438

Human   996 ADKKSMEWFTVIE-HYHRTSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYK 1059
            .|:::..|....| ..:.||.....|....:|.|||.:.|..|.||  .:....|::||
  Fly  2439 MDEETGRWIPAGEVGPNETSFDFKGLTPNKKYKFRVKAINKEGESE--PLETFDAIVAR------ 2495

Human  1060 NPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSV----------RGNP--------KPKITWM 1106
            ||    :|....|  :||:::.|.        |.||          .|.|        |.|....
  Fly  2496 NP----YDPPSPP--SQPVIDDYD--------NKSVLLKWKRPPSDGGRPITHYIVEIKDKFAPS 2546

Human  1107 KNKVAIVDDPRYRMFSNQGVCTLE-IRKPSPYDGGTYCCKAVNDLGTVE 1154
            .::||..|||...       |.:| :::...|.   :..:|||..|..|
  Fly  2547 WSEVAKTDDPNPE-------CNVEGLKEKMVYQ---FRVRAVNKAGPSE 2585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYBPC1	XP_006719468.1	IG_like	89..184	CDD:214653	27/111 (24%)
		Ig	89..173	CDD:299845	24/100 (24%)
		I-set	279..362	CDD:254352	17/83 (20%)
		Ig	304..363	CDD:299845	12/58 (21%)
		I-set	369..453	CDD:254352	25/87 (29%)
		IGc2	381..439	CDD:197706	21/60 (35%)
		IG_like	466..543	CDD:214653	21/91 (23%)
		Ig_C5_MyBP-C	556..641	CDD:143302	26/118 (22%)
		IG_like	559..641	CDD:214653	25/113 (22%)
		FN3	645..735	CDD:238020	35/108 (32%)
		FN3	744..846	CDD:238020	26/115 (23%)
		IG_like	872..953	CDD:214653	20/82 (24%)
		Ig	882..953	CDD:299845	19/72 (26%)
		FN3	957..1040	CDD:238020	24/84 (29%)
		I-set	1072..1161	CDD:254352	24/102 (24%)
		Ig	1089..1154	CDD:143165	19/83 (23%)
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845	23/97 (24%)
		IG_like	1503..1588	CDD:214653	24/92 (26%)
		I-set	1639..1724	CDD:254352	17/84 (20%)
		IG	1750..1821	CDD:214652	22/71 (31%)
		IGc2	1750..1806	CDD:197706	21/56 (38%)
		I-set	1826..1909	CDD:254352	21/82 (26%)
		Ig	1831..1897	CDD:299845	19/65 (29%)
		I-set	1914..1998	CDD:254352	13/84 (15%)
		Ig	2020..2095	CDD:299845	17/74 (23%)
		FN3	2100..2194	CDD:238020	36/121 (30%)
		FN3	2203..2292	CDD:238020	25/106 (24%)
		I-set	2311..2395	CDD:254352	22/84 (26%)
		Ig	2321..2395	CDD:299845	19/73 (26%)
		FN3	2399..2493	CDD:238020	27/95 (28%)
		FN3	2501..2590	CDD:238020	24/105 (23%)
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020
FN3	6754..6840	CDD:238020
I-set	6855..6946	CDD:254352
Ig	6874..6946	CDD:299845
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10772
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13817
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.100