DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phb2 and STOML1

DIOPT Version :9

Sequence 1:	NP_001097372.1	Gene:	Phb2 / 46038	FlyBaseID:	FBgn0010551	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_004800.2	Gene:	STOML1 / 9399	HGNCID:	14560	Length:	398	Species:	Homo sapiens

Alignment Length:	334	Identity:	66/334 - (19%)
Similarity:	127/334 - (38%)	Gaps:	82/334 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 RAIIFSRLGGIQSDIYSEGLHVRIPWFQYPIIYDIRSR-----PRKISSPTGSKDLQMINISLRV 109
            |.|:| |||.|::. ...|:.:.:|:.......|:|:|     |.|::|..|:           |
Human    87 RMIVF-RLGRIRTP-QGPGMVLLLPFIDSFQRVDLRTRAFNVPPCKLASKDGA-----------V 138

  Fly   110 LSRPDSLNLPYLHKQLGVDYDEKVLPSICNEVLKSVIAK--FNASQLITQRQQVSLLIRKEL--- 169
            ||             :|.|...:    |.:.||..:..|  ..|:::..|......|:::.|
Human   139 LS-------------VGADVQFR----IWDPVLSVMTVKDLNTATRMTAQNAMTKALLKRPLREI 186

  Fly   170 -VERARDFNIILDDVSLTELSFGKE---YTAAIEAKQVAQQEA-----------QRAVFFVERAK 219
             :|:.:..:.:|.:::....::|.|   ...|:||.....|::           |.|:.|: ...
Human   187 QMEKLKISDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSPAGPNLDSTLQQLALHFL-GGS 250

  Fly   220 QEKQQKIVQAEGEAEAAKMLG--------LAVKQNPAY-LKLRKLRAAQS-IARTIASSQNKVYL 274
            .........:.|.|:..:|:.        :..:.:|.. |....|.|.|. ::..:.|.....|.
Human   251 MNSMAGGAPSPGPADTVEMVSEVEPPAPQVGARSSPKQPLAEGLLTALQPFLSEALVSQVGACYQ 315

  Fly   275 SADSLMLNIQDSGFDDMTEKVYKIGTGLPKDWL----------DARKMASKVAQP-----AEKEK 324
            ....|....|.:.|.|:|....::|.|:| |.:          |.|.:..:..:|     :.:.|
Human   316 FNVVLPSGTQSAYFLDLTTGRGRVGHGVP-DGIPDVVVEMAEADLRALLCRELRPLGAYMSGRLK 379

  Fly   325 NVGNVASSM 333
            ..|::|.:|
Human   380 VKGDLAMAM 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phb2	NP_001097372.1	SPFH_prohibitin	42..236	CDD:259799	42/210 (20%)
STOML1	NP_004800.2	Tyrosine-type lysosomal sorting signal. /evidence=ECO:0000255, ECO:0000269\|PubMed:19696025	6..10
		PHB	77..217	CDD:214581	33/159 (21%)
		SPFH_SLP-1	94..224	CDD:259814	31/158 (20%)
		SCP2	304..395	CDD:280250	18/86 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810