DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phb2 and phb2

DIOPT Version :9

Sequence 1:	NP_001097372.1	Gene:	Phb2 / 46038	FlyBaseID:	FBgn0010551	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_588144.2	Gene:	phb2 / 2538888	PomBaseID:	SPCC1322.16	Length:	288	Species:	Schizosaccharomyces pombe

Alignment Length:	282	Identity:	158/282 - (56%)
Similarity:	214/282 - (75%)	Gaps:	9/282 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KLNDLAGKLGKGGPPG----LGIGLKVLAAVGAAAYGVSQSLYTVEGGHRAIIFSRLGGIQSDIY 65
            ::|||   :.:|.|.|    .|.||  |.|:|.|.:.|..||:.|:||||||.:||:|||::.||
pombe     9 QMNDL---MKRGLPKGKYAFTGTGL--LLALGLAGFAVQTSLFNVDGGHRAIKYSRIGGIKNLIY 68

  Fly    66 SEGLHVRIPWFQYPIIYDIRSRPRKISSPTGSKDLQMINISLRVLSRPDSLNLPYLHKQLGVDYD 130
            .||.|..|||.:..|.||:|::||.|||.||:|||||:||:.|||||||...||.:::.||.|||
pombe    69 PEGTHFLIPWIETAIDYDVRAKPRNISSLTGTKDLQMVNINCRVLSRPDVHALPKIYRTLGGDYD 133

  Fly   131 EKVLPSICNEVLKSVIAKFNASQLITQRQQVSLLIRKELVERARDFNIILDDVSLTELSFGKEYT 195
            |:|||||.|||||||:|:||||||||||::||.|:|:.|::||..|||:|||||||.:.|..|:|
pombe   134 ERVLPSIVNEVLKSVVAQFNASQLITQRERVSRLVRENLMKRAARFNILLDDVSLTHVQFSPEFT 198

  Fly   196 AAIEAKQVAQQEAQRAVFFVERAKQEKQQKIVQAEGEAEAAKMLGLAVKQNPAYLKLRKLRAAQS 260
            ||:||||:|||:||||.|:|:||:.|||..||:|:||..||:::|.|:|..|.:::||||..|:.
pombe   199 AAVEAKQIAQQDAQRATFYVDRARMEKQGFIVRAQGEGRAAQLIGEAIKNKPGFIELRKLETARE 263

  Fly   261 IARTIASSQNKVYLSADSLMLN 282
            ||..::.|.|||.|:|.:|:|:
pombe   264 IANILSKSNNKVMLNASTLLLD 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phb2	NP_001097372.1	SPFH_prohibitin	42..236	CDD:259799	122/193 (63%)
phb2	NP_588144.2	PHB	44..205	CDD:214581	102/160 (64%)
phb2	NP_588144.2	SPFH_prohibitin	45..239	CDD:259799	122/193 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	221	1.000	Domainoid score	I549
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5263
Inparanoid	1	1.050	306	1.000	Inparanoid score	I589
OMA	1	1.010	-	-		QHG63567
OrthoFinder	1	1.000	-	-		FOG0002111
OrthoInspector	1	1.000	-	-		oto101797
orthoMCL	1	0.900	-	-		OOG6_101763
Panther	1	1.100	-	-	LDO	PTHR23222
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2721
SonicParanoid	1	1.000	-	-		X1399
TreeFam	1	0.960	-	-
	14	13.860