DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phb2 and STOM

DIOPT Version :9

Sequence 1:	NP_001097372.1	Gene:	Phb2 / 46038	FlyBaseID:	FBgn0010551	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_004090.4	Gene:	STOM / 2040	HGNCID:	3383	Length:	288	Species:	Homo sapiens

Alignment Length:	268	Identity:	68/268 - (25%)
Similarity:	118/268 - (44%)	Gaps:	40/268 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KG-GPPG-LGIGLKVLAAVGAAAYGVSQSLYTVEGGHRAIIFSRLGGI-QSDIYSEGLHVRIPWF 76
            || ||.| :.:....|..|......:...:..::...||||| |||.| |......||...:|..
Human    25 KGLGPCGWILVAFSFLFTVITFPISIWMCIKIIKEYERAIIF-RLGRILQGGAKGPGLFFILPCT 88

  Fly    77 QYPIIYDIRS-----RPRKISSPTGSKDLQMINISLRVLSRPDSLNLPYLHKQLGVDYDEKVLPS 136
            ...|..|:|:     .|::|.    :||...|::...|..|..:..|...:    :...:.....
Human    89 DSFIKVDMRTISFDIPPQEIL----TKDSVTISVDGVVYYRVQNATLAVAN----ITNADSATRL 145

  Fly   137 ICNEVLKSVIAKFNASQLITQRQQVSLLIRKELVERARDFNIILDDVSLTELSFGKEYTAAIEAK 201
            :....|::|:...|.||:::.|:::           |.:....|||.  |: ::|.: ...:|.|
Human   146 LAQTTLRNVLGTKNLSQILSDREEI-----------AHNMQSTLDDA--TD-AWGIK-VERVEIK 195

  Fly   202 QV-AQQEAQRAVFFVERAKQEKQQKIVQAEGEAEAAKML---GLAVKQNPAYLKLRKLRAAQSIA 262
            .| ...:.|||:.....|.:|.:.|::.||||..|::.|   .:.:.::||.|:||.|:.    .
Human   196 DVKLPVQLQRAMAAEAEASREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQT----L 256

  Fly   263 RTIASSQN 270
            .|||:.:|
Human   257 TTIAAEKN 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phb2	NP_001097372.1	SPFH_prohibitin	42..236	CDD:259799	49/200 (25%)
STOM	NP_004090.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		SPFH_stomatin	73..274	CDD:259801	52/219 (24%)
		Required for homooligomerization	265..273		68/268 (25%)
		Required for lipid raft association	267..269
		Interaction with LANCL1. /evidence=ECO:0000269\|PubMed:9512664	273..287
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810