DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phb2 and Stom

DIOPT Version :9

Sequence 1:	NP_001097372.1	Gene:	Phb2 / 46038	FlyBaseID:	FBgn0010551	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_038543.1	Gene:	Stom / 13830	MGIID:	95403	Length:	284	Species:	Mus musculus

Alignment Length:	230	Identity:	53/230 - (23%)
Similarity:	102/230 - (44%)	Gaps:	36/230 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 RAIIFSRLGGI-QSDIYSEGLHVRIPWFQYPIIYDIRS-----RPRKISSPTGSKDLQMINISLR 108
            |.||| |||.| |......||...:|.....|..|:|:     .|:::.    :||...|::...
Mouse    62 RVIIF-RLGRILQGGAKGPGLFFILPCTDSLIKVDMRTISFDIPPQEVL----TKDSVTISVDGV 121

  Fly   109 VLSRPDSLNLPYLHKQLGVDYDEKVLPSICNEVLKSVIAKFNASQLITQRQQVSLLIRKELVERA 173
            |..|..:..|...:    :...:.....:....|::.:...|.||:::.|::::..::..|.:..
Mouse   122 VYYRVQNATLAVAN----ITNADSATRLLAQTTLRNALGTKNLSQILSDREEIAHHMQSTLDDAT 182

  Fly   174 RDFNIILDDVSLTELSFGKEYTAAIEAKQVAQQEAQRAVFFVERAKQEKQQKIVQAEGEAEAAKM 238
            .|:.|.::.|.:.::..              ..:.|||:.....|.:|.:.|::.||||..|::.
Mouse   183 DDWGIKVERVEIKDVKL--------------PVQLQRAMAAEAEAAREARAKVIAAEGEMNASRA 233

  Fly   239 L---GLAVKQNPAYLKLRKLRAAQSIARTIASSQN 270
            |   .:.:.::||.|:||.|:.    ..|||:.:|
Mouse   234 LKEASMVITESPAALQLRYLQT----LTTIAAEKN 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phb2	NP_001097372.1	SPFH_prohibitin	42..236	CDD:259799	41/191 (21%)
Stom	NP_038543.1	PHB	53..204	CDD:214581	31/164 (19%)
		SPFH_stomatin	73..274	CDD:259801	45/218 (21%)
		Required for homooligomerization. /evidence=ECO:0000250	265..273		53/230 (23%)
		Required for lipid raft association. /evidence=ECO:0000250	267..269
		Interaction with LANCL1. /evidence=ECO:0000250	273..284
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900