DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phb2 and PHB2

DIOPT Version :9

Sequence 1:NP_001097372.1 Gene:Phb2 / 46038 FlyBaseID:FBgn0010551 Length:338 Species:Drosophila melanogaster
Sequence 2:NP_001138303.1 Gene:PHB2 / 11331 HGNCID:30306 Length:299 Species:Homo sapiens


Alignment Length:298 Identity:210/298 - (70%)
Similarity:261/298 - (87%) Gaps:3/298 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAQSKLNDLAGKLGKGGPPGLGIGLKVLAAVGAAAYGVSQSLYTVEGGHRAIIFSRLGGIQSD-I 64
            |||: |.||||:| ..||.|:|..||:|...||.||||.:|::|||||||||.|:|:||:|.| |
Human     1 MAQN-LKDLAGRL-PAGPRGMGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTI 63

  Fly    65 YSEGLHVRIPWFQYPIIYDIRSRPRKISSPTGSKDLQMINISLRVLSRPDSLNLPYLHKQLGVDY 129
            .:||||.||||||||||||||:||||||||||||||||:||||||||||::..||.::::||:||
Human    64 LAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDY 128

  Fly   130 DEKVLPSICNEVLKSVIAKFNASQLITQRQQVSLLIRKELVERARDFNIILDDVSLTELSFGKEY 194
            :|:|||||.|||||||:||||||||||||.|||||||:||.|||:||::|||||::|||||.:||
Human   129 EERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREY 193

  Fly   195 TAAIEAKQVAQQEAQRAVFFVERAKQEKQQKIVQAEGEAEAAKMLGLAVKQNPAYLKLRKLRAAQ 259
            |||:|||||||||||||.|.||:||||::|||||||||||||||||.|:.:||.|:||||:||||
Human   194 TAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQ 258

  Fly   260 SIARTIASSQNKVYLSADSLMLNIQDSGFDDMTEKVYK 297
            :|::|||:|||::||:||:|:||:||..|...::.:.|
Human   259 NISKTIATSQNRIYLTADNLVLNLQDESFTRGSDSLIK 296

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Phb2NP_001097372.1 SPFH_prohibitin 42..236 CDD:259799 151/194 (78%)
PHB2NP_001138303.1 Necessary for transcriptional repression. /evidence=ECO:0000269|PubMed:10359819 19..49 17/29 (59%)
SPFH_prohibitin 40..235 CDD:259799 151/194 (78%)
LC3-interaction region. /evidence=ECO:0000269|PubMed:28017329 121..124 0/2 (0%)
Necessary for transcriptional repression. /evidence=ECO:0000269|PubMed:10359819 150..174 20/23 (87%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146875
Domainoid 1 1.000 283 1.000 Domainoid score I1653
eggNOG 1 0.900 - - E1_COG0330
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H5263
Inparanoid 1 1.050 416 1.000 Inparanoid score I1831
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63567
OrthoDB 1 1.010 - - D1089994at2759
OrthoFinder 1 1.000 - - FOG0002111
OrthoInspector 1 1.000 - - oto91043
orthoMCL 1 0.900 - - OOG6_101763
Panther 1 1.100 - - LDO PTHR23222
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2721
SonicParanoid 1 1.000 - - X1399
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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