DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ccs and Ccs

DIOPT Version :9

Sequence 1:	NP_001163108.1	Gene:	Ccs / 46035	FlyBaseID:	FBgn0010531	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	NP_445877.1	Gene:	Ccs / 84485	RGDID:	620403	Length:	274	Species:	Rattus norvegicus

Alignment Length:	264	Identity:	122/264 - (46%)
Similarity:	175/264 - (66%)	Gaps:	22/264 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IEFAVQMRRGDESYAGALRSALD---GVGQVEIDTQEGRVIIQTQRPWSEIQDKIEATGVRAVLS 67
            :||.|||  ..:|...|:...|.   ||..||:..:...|::||..|..|:|..:|:||.:|||.
  Rat    14 LEFTVQM--SCQSCVDAVHKTLKGAAGVQNVEVQLENQMVLVQTTLPSQEVQALLESTGRQAVLK 76

  Fly    68 GFGGQ------SAVALINTTGSVVDKTPIQGVVRFTTITADKKPGVVVDGVVDGLSPGLHGLHIH 126
            |.|..      :|||::..:|:|      ||||||..::::.   .:::|.:|||.|||||||:|
  Rat    77 GMGSSQLKNLGAAVAIMEGSGTV------QGVVRFLQLSSEL---CLIEGTIDGLEPGLHGLHVH 132

  Fly   127 ESGDTSAGCSSVGEHYNPRQSPHGSPAAGAEERHAGDLGNIRADENGRATFRFVDPVLEVWDIIG 191
            :.||.:..|||.|:|:||..:.||.|.  ..:||.|||||:.|:.:||||||..|..|:|||:||
  Rat   133 QYGDLTKDCSSCGDHFNPDGASHGGPQ--DTDRHRGDLGNVHAEASGRATFRIEDKQLKVWDVIG 195

  Fly   192 RAVVLTANADDLGRGGNDQSLIDGNSGERIACGIIARSAGILENFKRICACDGVTLWDERNKPLA 256
            |::|:....|||||||:..|.:.||||:|:||||||||||:.:|.|:||:|||:|:|:||.:|:|
  Rat   196 RSLVVDEGEDDLGRGGHPLSKVTGNSGKRLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIA 260

  Fly   257 GKER 260
            |:.|
  Rat   261 GQGR 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ccs	NP_001163108.1	PLN02957	1..253	CDD:215516	118/255 (46%)
		HMA	5..64	CDD:238219	21/60 (35%)
		Cu-Zn_Superoxide_Dismutase	72..223	CDD:238186	71/156 (46%)
Ccs	NP_445877.1	PLN02957	13..253	CDD:215516	113/247 (46%)
		HMA	15..73	CDD:238219	21/60 (35%)
		Superoxide dismutase-like	88..234		71/145 (49%)
		Cu-Zn_Superoxide_Dismutase	89..227	CDD:238186	66/137 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334436
Domainoid	1	1.000	156	1.000	Domainoid score	I4107
eggNOG	1	0.900	-	-		E1_COG2608
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3762
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3302
OMA	1	1.010	-	-		QHG55645
OrthoDB	1	1.010	-	-		D1527306at2759
OrthoFinder	1	1.000	-	-		FOG0000641
OrthoInspector	1	1.000	-	-		oto95571
orthoMCL	1	0.900	-	-		OOG6_105544
Panther	1	1.100	-	-	LDO	PTHR10003
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810