DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ccs and ccs

DIOPT Version :9

Sequence 1:	NP_001163108.1	Gene:	Ccs / 46035	FlyBaseID:	FBgn0010531	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	NP_001191151.2	Gene:	ccs / 550489	ZFINID:	ZDB-GENE-050417-322	Length:	267	Species:	Danio rerio

Alignment Length:	264	Identity:	128/264 - (48%)
Similarity:	179/264 - (67%)	Gaps:	21/264 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KIEFAVQMRRGDESYAGALRSALD---GVGQVEIDTQEGRVIIQTQRPWSEIQDKIEATGVRAVL 66
            |:||||||  ..:|...|:::.|:   ||..|:::..:..|:::|.....::|..||:||.||||
Zfish     8 KLEFAVQM--SCDSCVNAVKAVLEKDPGVQSVQVNLSKEEVLVETALTSLQVQTLIESTGRRAVL 70

  Fly    67 SGFGGQ-----SAVALINTTGSVVDKTPIQGVVRFTTITADKKPGVVVDGVVDGLSPGLHGLHIH 126
            .|.||.     :|||:::..|.|      ||||||..::.|:   .::||.:||||||.||||:|
Zfish    71 KGMGGSDSDLGAAVAMLSGAGLV------QGVVRFLQLSHDR---CLIDGTIDGLSPGAHGLHVH 126

  Fly   127 ESGDTSAGCSSVGEHYNPRQSPHGSPAAGAEERHAGDLGNIRADENGRATFRFVDPVLEVWDIIG 191
            |.||.:..|.|.|:|:||.:..||:|.  ..:||.||||||.|..:|||:||..|..::|||:||
Zfish   127 ELGDLTQDCRSCGDHFNPFRKQHGAPQ--DSDRHVGDLGNISAGPDGRASFRLEDSQIKVWDVIG 189

  Fly   192 RAVVLTANADDLGRGGNDQSLIDGNSGERIACGIIARSAGILENFKRICACDGVTLWDERNKPLA 256
            |::|:.:..||||||.:..|...||||||:||||||||||:.:|.|:||||||||||:||::|:|
Zfish   190 RSLVVDSGEDDLGRGNHPLSKTTGNSGERLACGIIARSAGLFQNPKQICACDGVTLWEERDRPIA 254

  Fly   257 GKER 260
            ||.|
Zfish   255 GKGR 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ccs	NP_001163108.1	PLN02957	1..253	CDD:215516	123/255 (48%)
		HMA	5..64	CDD:238219	20/61 (33%)
		Cu-Zn_Superoxide_Dismutase	72..223	CDD:238186	72/155 (46%)
ccs	NP_001191151.2	PLN02957	9..247	CDD:215516	119/250 (48%)
		HMA	10..68	CDD:238219	19/59 (32%)
		Cu-Zn_Superoxide_Dismutase	83..221	CDD:238186	72/148 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573466
Domainoid	1	1.000	155	1.000	Domainoid score	I4204
eggNOG	1	0.900	-	-		E1_COG2608
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3762
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3282
OMA	1	1.010	-	-		QHG55645
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000641
OrthoInspector	1	1.000	-	-		oto41202
orthoMCL	1	0.900	-	-		OOG6_105544
Panther	1	1.100	-	-	LDO	PTHR10003
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4858
SonicParanoid	1	1.000	-	-		X4274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790