Protein Alignment MYBL1 and Myb

DIOPT Version :10

• Sequence 1: XP_016868944.1
• Gene: MYBL1 / 4603
• HGNCID: 7547
• Length: 770
• Species: Homo sapiens
• Sequence 2: NP_511170.1
• Gene: Myb / 32543
• FlyBaseID: FBgn0002914
• Length: 657
• Species: Drosophila melanogaster
• Alignment Length: 806
• Identity: 236/806 - (29%)
• Similarity: 338/806 - (41%)
• Gaps: 254/806 - (31%)

Human    23 EDDDLQYADHD------------YEVPQ--------QKGLKKLWNR------------VKWTRDE 55
            |::|.|..|.|            .:.|:        |||..|....            .:|::.|
  Fly    28 ENEDTQVCDKDSQQNSNADSGYPLDSPELQDSKTTGQKGQNKSGKTSIGAVHPNYGFGKRWSKSE 92

Human    56 DDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGP 120
            |..||:|||.|| ::|.:|..|.::|.:.|.|.||.|||||||||||||::||..||:||:.:||
  Fly    93 DVLLKQLVETHG-ENWEIIGPHFKDRLEQQVQQRWAKVLNPELIKGPWTRDEDDMVIKLVRNFGP 156

Human   121 KRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRT 185
            |:|:|||::|.|||||||||||||||||.:||::|||:||.|||:||..|||:||:|||.|||||
  Fly   157 KKWTLIARYLNGRIGKQCRERWHNHLNPNIKKTAWTEKEDEIIYQAHLELGNQWAKIAKRLPGRT 221

Human   186 DNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCAAMDHMQTQNQFYIPVQIPGYQYVS 250
            ||:||||||||||||.:.|....:...|:..||:         .|:.|.      ::..|.
  Fly   222 DNAIKNHWNSTMRRKYDVERRSVNASGSDLKSSR---------THLITL------IKSGGI---- 267

Human   251 PEGNCIEHVQPTSAFIQQPFIDEDPDKEKKIKELEMLLMSAENEVRRKRIPSQPGSFSSWSGSFL 315
              ..|:.::|              .:||            :..|...|...:...|.::..|..|
  Fly   268 --SKCMNNMQ--------------HNKE------------SGGEAVNKSENADGASVTAVKGGDL 304

Human   316 MDDNMSNTLNSLDEHTSEFYSMDENQPVSAQQNSPTKFLAVEANAVLSSLQTIPEFAETLELIES 380
            ..:       |.|:|               |:.|....|:::....|    |:|.
  Fly   305 AQE-------SQDDH---------------QKGSNLAHLSMQHLIKL----TMPR---------- 333

Human   381 FNLLQDPVAWSDVTSFDISDAAASPIKSTPVKLMRIQHNEGAMECQ-FNVSLVLEGKKNTCNGGN 444
                |.|:.                :|.|...:....|..|....: ||....         .||
  Fly   334 ----QTPII----------------LKRTRKHIPETHHQAGCSSSETFNQEEA---------AGN 369

Human   445 SEAVPLTSPNIAKFSTPPAILRKKRKMRVGHSPGSELRDGSLNDGGNMALKHTPLKTLPFSPSQF 509
            :.:.|.:||.|                                         :|:|:||||||.|
  Fly   370 ARSRPPSSPVI-----------------------------------------SPIKSLPFSPSHF 393

Human   510 FNTCPGNEQLNIENPSFTSTPICGQKALITTPLHKETTP-----KDQKENVGFRTPTIRRSILGT 569
                       :::|..|:......:|  :||:.|....     |.:.|.....||  .:|.||
  Fly   394 -----------LKSPCLTTFEDMDLRA--STPVTKVYNRVGMEIKKEMETSSIETP--HKSQLG- 442

Human   570 TPRTPTPFKNALAAQEKK-----YGPLKIVSQPLAFLEEDIREVLKEETGTDLFLKEEDEPAYKS 629
             ||||||||.||||..||     |.|    |.| :.|.||:.|::.||..:: .|...:.....:
  Fly   443 -PRTPTPFKKALAAIGKKRDGRRYEP----SSP-SSLVEDLAEIIHEEHLSN-SLTANNSKMMGA 500

Human   630 CKQENTASG----------KKVRKSLVLDNWEKEESGTQLLTEDISDMQSE--NRFTTSLLMIPL 682
            ..|.:|.|.          |:.|||| |..|...........:.|...::|  ::|.||    |.
  Fly   501 ADQNSTLSTEYNAQSPPHMKRARKSL-LSTWSSNHPYNAGSAKRIQPFETETPSKFLTS----PG 560

Human   683 LEIHDNRCNLIPEKQDINSTNKTYTLTKKKPNP-NTSKVVKLEKNLQ----SNCEWETVVYGKTE 742
            ..:.|..|:    :||:     .:...:|:..| :..::.|....|.    .:.:|..|..||:.
  Fly   561 DILKDTLCS----EQDL-----PFDEGRKENRPFHNRRINKYRGGLTYDHVIDPKWARVACGKSR 616

Human   743 DQLIMTEQARRYLSTYTATSSTSRAL 768
            ||:.|.|||...|..   .|..||:|
  Fly   617 DQMFMEEQAYACLKN---LSCISRSL 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYBL1	XP_016868944.1	Myb_DNA-bind_6	51..111	CDD:372817	33/59 (56%)
		PLN03091	97..>283	CDD:215570	89/185 (48%)
		Cmyb_C	504..660	CDD:462753	53/175 (30%)
Myb	NP_511170.1	Myb_DNA-bind_6	88..147	CDD:372817	33/59 (56%)
		PLN03212	136..>236	CDD:178751	73/99 (74%)
		Cmyb_C	388..>484	CDD:462753	40/117 (34%)