DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYBL1 and Myb

DIOPT Version :9

Sequence 1:	XP_016868944.1	Gene:	MYBL1 / 4603	HGNCID:	7547	Length:	770	Species:	Homo sapiens
Sequence 2:	NP_511170.1	Gene:	Myb / 32543	FlyBaseID:	FBgn0002914	Length:	657	Species:	Drosophila melanogaster

Alignment Length:	806	Identity:	236/806 - (29%)
Similarity:	338/806 - (41%)	Gaps:	254/806 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    23 EDDDLQYADHD------------YEVPQ--------QKGLKKLWNR------------VKWTRDE 55
            |::|.|..|.|            .:.|:        |||..|....            .:|::.|
  Fly    28 ENEDTQVCDKDSQQNSNADSGYPLDSPELQDSKTTGQKGQNKSGKTSIGAVHPNYGFGKRWSKSE 92

Human    56 DDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGP 120
            |..||:|||.|| ::|.:|..|.::|.:.|.|.||.|||||||||||||::||..||:||:.:||
  Fly    93 DVLLKQLVETHG-ENWEIIGPHFKDRLEQQVQQRWAKVLNPELIKGPWTRDEDDMVIKLVRNFGP 156

Human   121 KRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRT 185
            |:|:|||::|.|||||||||||||||||.:||::|||:||.|||:||..|||:||:|||.|||||
  Fly   157 KKWTLIARYLNGRIGKQCRERWHNHLNPNIKKTAWTEKEDEIIYQAHLELGNQWAKIAKRLPGRT 221

Human   186 DNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCAAMDHMQTQNQFYIPVQIPGYQYVS 250
            ||:||||||||||||.:.|....:...|:..||:         .|:.|.      ::..|.
  Fly   222 DNAIKNHWNSTMRRKYDVERRSVNASGSDLKSSR---------THLITL------IKSGGI---- 267

Human   251 PEGNCIEHVQPTSAFIQQPFIDEDPDKEKKIKELEMLLMSAENEVRRKRIPSQPGSFSSWSGSFL 315
              ..|:.::|              .:||            :..|...|...:...|.::..|..|
  Fly   268 --SKCMNNMQ--------------HNKE------------SGGEAVNKSENADGASVTAVKGGDL 304

Human   316 MDDNMSNTLNSLDEHTSEFYSMDENQPVSAQQNSPTKFLAVEANAVLSSLQTIPEFAETLELIES 380
            ..:       |.|:|               |:.|....|:::....|    |:|.
  Fly   305 AQE-------SQDDH---------------QKGSNLAHLSMQHLIKL----TMPR---------- 333

Human   381 FNLLQDPVAWSDVTSFDISDAAASPIKSTPVKLMRIQHNEGAMECQ-FNVSLVLEGKKNTCNGGN 444
                |.|:.                :|.|...:....|..|....: ||....         .||
  Fly   334 ----QTPII----------------LKRTRKHIPETHHQAGCSSSETFNQEEA---------AGN 369

Human   445 SEAVPLTSPNIAKFSTPPAILRKKRKMRVGHSPGSELRDGSLNDGGNMALKHTPLKTLPFSPSQF 509
            :.:.|.:||.|                                         :|:|:||||||.|
  Fly   370 ARSRPPSSPVI-----------------------------------------SPIKSLPFSPSHF 393

Human   510 FNTCPGNEQLNIENPSFTSTPICGQKALITTPLHKETTP-----KDQKENVGFRTPTIRRSILGT 569
                       :::|..|:......:|  :||:.|....     |.:.|.....||  .:|.||
  Fly   394 -----------LKSPCLTTFEDMDLRA--STPVTKVYNRVGMEIKKEMETSSIETP--HKSQLG- 442

Human   570 TPRTPTPFKNALAAQEKK-----YGPLKIVSQPLAFLEEDIREVLKEETGTDLFLKEEDEPAYKS 629
             ||||||||.||||..||     |.|    |.| :.|.||:.|::.||..:: .|...:.....:
  Fly   443 -PRTPTPFKKALAAIGKKRDGRRYEP----SSP-SSLVEDLAEIIHEEHLSN-SLTANNSKMMGA 500

Human   630 CKQENTASG----------KKVRKSLVLDNWEKEESGTQLLTEDISDMQSE--NRFTTSLLMIPL 682
            ..|.:|.|.          |:.|||| |..|...........:.|...::|  ::|.||    |.
  Fly   501 ADQNSTLSTEYNAQSPPHMKRARKSL-LSTWSSNHPYNAGSAKRIQPFETETPSKFLTS----PG 560

Human   683 LEIHDNRCNLIPEKQDINSTNKTYTLTKKKPNP-NTSKVVKLEKNLQ----SNCEWETVVYGKTE 742
            ..:.|..|:    :||:     .:...:|:..| :..::.|....|.    .:.:|..|..||:.
  Fly   561 DILKDTLCS----EQDL-----PFDEGRKENRPFHNRRINKYRGGLTYDHVIDPKWARVACGKSR 616

Human   743 DQLIMTEQARRYLSTYTATSSTSRAL 768
            ||:.|.|||...|..   .|..||:|
  Fly   617 DQMFMEEQAYACLKN---LSCISRSL 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYBL1	XP_016868944.1	None
Myb	NP_511170.1	SANT	85..132	CDD:197842	21/47 (45%)
		Myb_DNA-bind_6	88..147	CDD:290632	33/59 (56%)
		SANT	136..184	CDD:197842	34/47 (72%)
		Myb_DNA-bind_6	139..197	CDD:290632	39/57 (68%)
		SANT	188..235	CDD:197842	35/46 (76%)
		Myb_DNA-binding	188..233	CDD:278669	33/44 (75%)
		Cmyb_C	388..530	CDD:286408	52/165 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151991
Domainoid	1	1.000	49	1.000	Domainoid score	I11796
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3115
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119160at33208
OrthoFinder	1	1.000	-	-		FOG0000329
OrthoInspector	1	1.000	-	-		otm41481
orthoMCL	1	0.900	-	-		OOG6_100129
Panther	1	1.100	-	-	LDO	PTHR45614
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2047
SonicParanoid	1	1.000	-	-		X1086
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790